This chapter presents the central theory the book explores. After a brief review of prevailing functionalist and power-based approaches, it argues that to understand when informal organizations will be established one must explain, first, how states form preference as to the legal designs of international organizations, and second, whose preferences are likely to hold sway when states join each other at the negotiating table. The theory of preference formation emphasizes the importance of domestic institutional structures, levels of domestic constraints, and levels of politicization. The account of preference aggregation processes, or bargaining, emphasizes the structure of the bargaining scenario and the distribution of power. The final part of the chapter outlines the more dynamic theory of informality that is offered. This account explains how domestic shifts within powerful states—especially growing polarization and the rise of the regulatory state—have projected outward and reshaped the global system.