Chapter 23 highlights the flexibility and adaptability of this transdiagnostic, unified approach to treating emotional disorders in children and adolescents. These treatments target a common set of underlying features of emotional disorders (e.g., high levels of intense emotions, distress reactions to intense emotions, unhelpful behavioral choices when experiencing intense emotions). Thus, the skills detailed in these treatments are applicable to disorders or problem area sharing these core features. These include anxiety and depressive disorders and obsessive-compulsive (OC) spectrum disorders, tic disorders, stress-related disorders, somatic symptom disorders, and potentially even some eating disorders. This chapter reviews some of the most common modifications that may be needed for using the UP-C and UP-A under different conditions and with different types of symptom presentations.