This chapter offers a regional perspective on differentiated integration. It shows that the EU has developed a variegated set of membership grades, cross-cutting the formal boundary between member and non-member states. The chapter shows that internal and external differentiation are driven by the logics of instrumental and constitutional differentiation. In the EU’s internal differentiation, poorer (new) member states are more likely to experience differentiation because of weak governance capacity, low regulatory standards, budgetary competition, and migration pressure. The chapter extends this reasoning to European countries with comparatively weak governance quality. The lower the governance quality of a country, the earlier it is refused further integration on the EU’s ladder of graded membership. The more its governance quality improves, the better are its chances to advance towards full membership. In turn, as their governance quality surpasses that of EU core members, countries become increasingly likely to refuse integration.