This chapter examines the impact of the relation between the Persian conquerors and the local Babylonians on the cultural continuity in Babylonia during the mid-first millennium BCE. It suggests that the evidence of Persian adoption of Babylonian traditions is manifest not only in administrative and social systems, but also in the visual arts and iconography. The analysis of corpora of seal impressions from Babylonian and Achaemenid archives reveal a complex and slowly evolving relationship between the two traditions, reflecting, but not temporally correlative with, political developments.