Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

2022 ◽  
Author(s):  
Nafeesa Khatoon ◽  
Zefei Zhang ◽  
Chunhui Zhou ◽  
Maoquan Chu
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Systemic Toxicity ◽  
Coated Nanoparticles ◽  
Biomimetic Approach ◽  
Targeted Drug ◽  
Macrophage Membrane

The enhanced and targeted drug delivery with low systemic toxicity and subsequent release of drugs is the major concern among researchers and pharmaceutics. Inspite of greater advancement and discoveries in...

scholarly journals Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

2015 ◽  
Vol 6 (8) ◽  
pp. 1286-1299 ◽  
Author(s):  
D. D. Lane ◽  
D. Y. Chiu ◽  
F. Y. Su ◽  
S. Srinivasan ◽  
H. B. Kern ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Raft Polymerization ◽  
Chemotherapeutic Agents ◽  
Polymer Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Targeted Drug

Second generation polymeric brushes with molecular weights in excess of 106 Da were synthesize via RAFT polymerization for use as antibody targeted drug delivery vehicles.

Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

2020 ◽  
Vol 8 (21) ◽  
pp. 4648-4659 ◽  
Author(s):  
Long Wu ◽  
Wei Xie ◽  
Hui-Ming Zan ◽  
Zhongzhong Liu ◽  
Ganggang Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Platelet Membrane ◽  
Coated Nanoparticles ◽  
Controllable Release ◽  
Targeted Drug

Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.

scholarly journals Alginate-Based Platforms for Cancer-Targeted Drug Delivery

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Lili He ◽  
Zhenghui Shang ◽  
Hongmei Liu ◽  
Zhi-xiang Yuan
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Delivery Systems ◽  
Cancer Targeting ◽  
Innovative Strategies ◽  
General Chemical ◽  
Different Types ◽  
Targeted Drug ◽  
Potential Use

As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kinds of alginate-based carriers are introduced. Finally, recent innovative strategies to functionalize alginate-based vehicles for cancer targeting are described to highlight research towards the optimization of alginate.

Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles

2020 ◽  
Vol 66 (6) ◽  
pp. 464-468
Author(s):  
L.V. Kostryukova ◽  
Y.A. Tereshkina ◽  
E.I. Korotkevich ◽  
V.N. Prozorovsky ◽  
T.I. Torkhovskaya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Breast Adenocarcinoma ◽  
Control Line ◽  
Phospholipid Nanoparticles ◽  
Significant Difference ◽  
Targeted Drug ◽  
Cd13 Receptor

Doxorubicin is one of the widely known and frequently used chemotherapy drugs for the treatment of various types of cancer, the use of which is difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed to reduce side effects. One of the promising components as vector molecules (ligands) are NGR-containing peptides that are affinity for the CD13 receptor, which is expressed on the surface of many tumor cells and tumor blood vessels. Previously, a method was developed for preparing a composition of doxorubicin embedded in phospholipid nanoparticles with a targeted fragment in the form of an ultrafine emulsion. The resulting composition was characterized by a small particle size (less than 40 nm) and a high degree of incorporation of doxorubicin (about 93%) into transport nanoparticles. When assessing the penetrating ability and the degree of binding to the surface of fibrosarcoma cells (HT-1080), it was shown that when the composition with the targeted fragment was added to the cells, the level of doxorubicin was almost 2 times higher than that of the liposomal form of doxorubicin, i.e. the drug in the system with the targeted peptide penetrated the cell better. At the same time, on the control line of breast adenocarcinoma cells (MCF-7), which do not express the CD13 receptor on the surface, there was not significant difference in the level of doxorubicin in the cells. The data obtained allow us to draw preliminary conclusions about the prospects of targeted delivery of doxorubicin to tumor cells when using a peptide conjugate containing an NGR motif and the further need for its comprehensive study.

scholarly journals Abstract P-34: Cryo-EM Study of Submicrocapsules with a Shell of Nanoparticle Heteroaggregates and Polyelectrolyte Layers

2021 ◽  
Vol 11 (Suppl_1) ◽  
pp. S26-S27
Author(s):  
Anastasiya Kostenko ◽  
Konstantin Palamarchuk ◽  
Yury Chesnokov ◽  
Konstantin Plokhikh ◽  
Tatyana Bukreeva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Colloidal Particles ◽  
Electron Tomography ◽  
Physical Adsorption ◽  
Sio2 Nanoparticles ◽  
Silicon Dioxide Nanoparticles ◽  
Liquid Form ◽  
Targeted Drug

Background: Currently, different approaches of active and passive targeted drug delivery are being developed. One of the most promising methods of targeted drug delivery is the use of capsules. For instance, colloidosomes—capsules consisting of the shell formed by colloidal particles at the interface of the emulsion—can be used for targeted delivery of antitumor drugs or any other drugs in liquid form. Here we present results of cryo-EM study of submicrocapsules with the soybean oil core and with the shell consisting of SiO2 nanoparticles and detonation nanodiamonds (DNDs) stabilized with chitosan and alginate. Methods: Сryo-electron tomography (Cryo-ET) was used to identify the morphological features of the submicrocapsules. Preliminary screening of samples and cryo-ET data collection were performed using Titan Krios cryo-EM (ThermoFisher Scientific, US) equipped with Falcon 2 direct electron detector. The restoration of the tomographic series was carried out using IMOD software. Eman2 was used for segmentation and UCSF Chimera was used for visualization of the 3D model. Submicron capsules were obtained by stabilizing oil droplets with a mixture of SiO2 nanoparticles and DNDs. To form a stable shell, an additional layer of silica particles and polyelectrolyte layers of alginate/chitosan were applied to the droplets of the dispersed phase of the emulsion by physical adsorption. Results: Cryo-EM data showed the presence of submicrocapsules with a diameter in the range of 200-900 nm. Although a significant fraction of submicrocapsules was found to be partially destroyed, results of cryo-ET study of intact capsules demonstrated that silicon dioxide nanoparticles form a net, while DNDs form clusters. Conclusion: Here we demonstrate the results of the study of submicron capsules with a shell of silica nanoparticles and DNDs. It was found that a uniform distribution of DNDs is not a prerequisite for the creation of submicron capsules that contradicts the theoretical model.

scholarly journals Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

2014 ◽  
Vol 5 ◽  
pp. 937-945 ◽  
Author(s):  
Amanee D Salaam ◽  
Patrick Hwang ◽  
Roberus McIntosh ◽  
Hadiyah N Green ◽  
Ho-Wook Jun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cell Death ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Treatment Regimens ◽  
Targeted Drug ◽  
Prostate Cancers

The field of nanomedicine has emerged as an approach to enhance the specificity and efficacy of cancer treatments as stand-alone therapies and in combination with standard chemotherapeutic treatment regimens. The current standard of care for metastatic cancer, doxorubicin (DOX), is presented with challenges, namely toxicity due to a lack of specificity and targeted delivery. Nano-enabled targeted drug delivery systems can provide an avenue to overcome these issues. Nanodiamonds (ND), in particular, have been researched over the past five years for use in various drug delivery systems but minimal work has been done that incorporates targeting capability. In this study, a novel targeted drug delivery system for bone metastatic prostate cancer was developed, characterized, and evaluated in vitro. NDs were conjugated with the Asp–Gly–Glu–Ala (DGEA) peptide to target α2β1 integrins over-expressed in prostate cancers during metastasis. To facilitate drug delivery, DOX was adsorbed to the surface of the ND-DGEA conjugates. Successful preparation of the ND-DGEA conjugates and the ND-DGEA+DOX system was confirmed with transmission electron microscopy, hydrodynamic size, and zeta potential measurements. Since traditional DOX treatment regimens lack specificity and increased toxicity to normal tissues, the ND-DGEA conjugates were designed to distinguish between cells that overexpress α2β1 integrin, bone metastatic prostate cancers cells (PC3), and cells that do not, human mesenchymal stem cells (hMSC). Utilizing the ND-DGEA+DOX system, the efficacy of 1 µg/mL and 2 µg/mL DOX doses increased from 2.5% to 12% cell death and 11% to 34% cell death, respectively. These studies confirmed that the delivery and efficacy of DOX were enhanced by ND-DGEA conjugates. Thus, the targeted ND-DGEA+DOX system provides a novel approach for decreasing toxicity and drug doses.

scholarly journals TARGETED DRUG DELIVERY SYSTEMS IN BREAST CANCER CHEMOTHERAPY

2021 ◽  
Vol 77 (1) ◽  
pp. 12-16
Author(s):  
A.H. Al-Humairi ◽  
◽  
O.V. Ostrovsky ◽  
E.V. Zykova ◽  
D.L. Speransky ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Breast Cancer Chemotherapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

The article presents a review, systematizing the state and directions of development in the fabrication of targeted drug delivery systems in relation to the treatment of breast cancer. Drug delivery systems constructed on the basis of natural and artificial liposomes, nanoparticles of various nature, polymers, and dendrimer structures are consistently considered. For each class of platforms, information is provided on the features of the structure and functional properties of carriers, on successful examples of their use for the treatment of breast cancer at various stages of preclinical and clinical trials. The most probable directions to achieve a progress in the development of new systems for targeted delivery of antitumor drugs are shown.

scholarly journals Primary and Novel Approaches in Colon Targeted Drug Delivery System: A Review

2015 ◽  
Vol 3 (02) ◽  
pp. 37-57
Author(s):  
Komal . ◽  
Ujjwal Nautiyal ◽  
Ramandeep , Anita Devi Singh ◽  
Anita Devi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Local Treatment ◽  
Systemic Delivery ◽  
Colonic Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoeabiasis , colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the colon i.e. drug release and absorption should not occur in the stomach as well as the small intestine, and neither the bioactive agent should be degraded in either of the dissolution sites but only released and absorbed once the system reaches the colon. Different approaches are designed based on prodrug formulation, pHsensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The efficiency of drug delivery system is evaluated using different in vitro and in vivo release studies. This review article discusses, in brief, introduction to targeted drug delivery system, anatomy and physiology of the colon and approaches utilized in the colon targeted drug delivery system.

A Coupled Particle-Continuum Model of Nanoparticle Targeted Delivery Under Vascular Flow With Experimental Validation

2010 ◽  
Author(s):  
Yaling Liu ◽  
Kytai Nguyen ◽  
Manohara Mariyappa ◽  
Soujanya Kona ◽  
Jifu Tan
Keyword(s):  
Drug Delivery ◽  
Physical Properties ◽  
Flow Rate ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
System Level ◽  
Diffusion Reaction ◽  
Patient Specific ◽  
Convection Diffusion ◽  
Targeted Drug

Nanomedicine poses a new frontier in medical technology with the advantages of targeted delivery and patient specific design. In applications of nanoparticle targeted drug delivery, the delivery efficiency is controlled by the physical properties of the nanoparticle such as its size, shape, ligand density, as well as external environmental conditions such as flow rate and blood vessel diameter. Proper drug dosage choice relies on determination of the attachment and detachment rates of the nanoparticles at the active region and the understanding of the complex process of targeted drug delivery. A few particulate models have been proposed to study the adhesion individual spherical or non-spherical nanoparticles on receptor coated wall. Meanwhile, continuum convection-diffusion-reaction models have been widely used to calculate the drug concentration under various conditions, which usually assumes specific binding and de-binding constants. In reality, these binding and de-binding rates largely vary with physical properties of the particles and local flow conditions. However, there has not been any study that links the particulate level nanoparticle size and shape information to the system level bounded particle concentration. A hybrid particle binding dynamics and continuum convection-diffusion-reaction model is presented to study the effect of shear flow rate and particle size on binding efficiency. The simulated concentration of bounded nanoparticles agrees well with experimental results in flow chamber studies.

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