Long-distance travel by air has become immensely popular in modern times, but for the person with diabetes, it creates unique challenges including transportation of insulin and other supplies, performance of glucose-monitoring and insulin delivery devices within the aircraft, adaptation to new time zones and altered lifestyle, and titration of medications. There are no published guidelines for the management of diabetes in travelers. Safe flying with diabetes is all about planning ahead, packing adequate supplies, maintenance of cold chain for insulin, frequent monitoring of blood glucose and titration of medications as well as insulin, and minimizing the risk of hypoglycemia or hyperglycemia.