Today, many organizations look for more loyal, committed, and engaged employees. Employee engagement has two dimensions, which are work engagement and organizational engagement. In this chapter, the moderating effect of demographic variables in the relationship between mindfulness and work engagement is examined. Mindfulness is a concept which has its roots in Buddhism. Mindfulness is defined as a state of mind that enables an individual to be here and now with his/her full potential. This study aims to find the impact of demographic factors (gender, age, educational background, income, marital status) in the relationship between mindfulness and work engagement. Thus, the research question of this study is, Does the relationship between mindfulness and work engagement differ according to demographic factors such as sex, age, educational status, marital status, income level? In this study, quantitative research methodology will be used. In order to answer the research question, survey tool is applied to 142 white collar employees working in Istanbul at different sectors.