scholarly journals Effect of Oral Azithromycin vs Placebo on COVID-19 Symptoms in Outpatients With SARS-CoV-2 Infection

JAMA ◽  
2021 ◽  
Author(s):  
Catherine E. Oldenburg ◽  
Benjamin A. Pinsky ◽  
Jessica Brogdon ◽  
Cindi Chen ◽  
Kevin Ruder ◽  
...  
Keyword(s):  
Oral Azithromycin

scholarly journals Oral Azithromycin Pulse Therapy and Daily Topical Adapalene in the Treatment of Acne Vulgaris: An Open Randomized Noncomparative Study

2017 ◽  
Vol 28 (2) ◽  
pp. 52-56
Author(s):  
Mohammod Abu Hena Chowdhury ◽  
Shameem Al Mamun ◽  
Mohammad Jamal Uddin ◽  
Rashed Md Khan ◽  
M Mujibul Hoque ◽  
...  
Keyword(s):  
Cystic Lesion ◽  
Acne Vulgaris ◽  
Severity Index ◽  
Pulse Therapy ◽  
Inclusion Criteria ◽  
Noncomparative Study ◽  
Percent Reduction ◽  
Once Daily ◽  
Acne Lesion ◽  
Oral Azithromycin

The safety and efficacy of oral azithromycin and topical adapalene are well documented. In this study, concomitant use of oral azithromycin pulse therapy and daily topical adapalene in the treatment of acne vulgaris is assessed. A total of 37 patients fulfilled the inclusion criteria were enrolled. Azithromycin, 500 mg orally once daily first 3 days of 10 days' cycle for 9 cycle & topical Adapalene (0.5%) at night. Patients evaluated at 4 weeks' interval by using Michaelsson acne severity index. The overall assessment was made by percent reduction of acne lesions and severity score. At the end of 12 weeks' treatment 99.8% of comedones, 98.7% papular lesion, 94.3% pustular lesion and 88.8% infiltrated lesion were cleared. Only 2.9% cystic lesion responded to the regimens. Percent reduction of Michaelsson acne severity index was 87%, which was statistically highly significant. Overall assessment revealed acne lesion cleared in 22% cases, excellent improvement observed in 65% and 13% showed good response. Adverse effect was minimal. So, azithromycin pulse therapy and topical adapalene is indeed effective and safe in the treatment of acne vulgaris.Medicine Today 2016 Vol.28(2): 52-56

scholarly journals Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

2018 ◽  
Vol 68 (12) ◽  
pp. 2114-2116 ◽  
Author(s):  
Travis C Porco ◽  
John Hart ◽  
Ahmed M Arzika ◽  
Jerusha Weaver ◽  
Khumbo Kalua ◽  
...  
Keyword(s):  
Childhood Mortality ◽  
Timing Of Death ◽  
Oral Azithromycin

scholarly journals EFFECT OF ORAL AZITHROMYCIN AND METRONIDAZOLE AS AN ADJUNCT TO SCALING AND ROOT PLANING ON GLYCEMIC CONTROL IN TYPE II DIABETIC PATIENTS WITH CHRONIC PERIODONTITIS

2017 ◽  
Vol 10 (3) ◽  
pp. 449
Author(s):  
Dhivya K ◽  
Yogarajan K ◽  
Shanmugarajan T S
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Tertiary Care ◽  
Periodontal Therapy ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Type Ii ◽  
Oral Azithromycin

ABSTRACTObjective: Periodontitis, a chronic inflammatory disease characterized by destruction of the periodontal ligament and alveolar bone is the sixthcomplication of diabetes mellitus. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Therefore, thepresent study was designed to determine the effect of treating chronic periodontitis with oral antibiotics azithromycin and metronidazole on the levelof serum glycated hemoglobin in type-II diabetic patients.Methods: This prospective observational study was carried out in the dental department of a tertiary care hospital for 9 months. Clinical andbiochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Packagefor Social Sciences 17 and Graph Pad Prism 7.0.Results: Significant reduction in all the clinical and dental parameters was comparatively higher in patients who received azithromycin than inpatients who received metronidazole and scaling and root planning alone.Conclusion: Periodontal therapy with oral azithromycin can be employed as a supportive strategy for the management of diabetes mellitus.Henceforth, prevention and control of periodontal disease along with antibiotics must be considered an integral part of glycemic control. However,due to the lesser sample size in this study, further investigations are required to confirm the effect of periodontal therapy on systemic diseases.Keywords: Periodontitis, Azithromycin, Metronidazole, Glycemic control, Diabetes mellitus.

scholarly journals P98 Weekly pulses of oral azithromycin for the treatment of EGFRIs related papulopustular eruption

2010 ◽  
Vol 20 ◽  
pp. e84-e85
Author(s):  
V. Nikolaou ◽  
A. Strimpakos ◽  
A. Stratigos ◽  
C. Antoniou ◽  
A. Katsambas ◽  
...  
Keyword(s):  
Papulopustular Eruption ◽  
Oral Azithromycin

scholarly journals Prevalence of Chlamydia pneumoniae seropositivity in early pregnancy and its association with preeclampsia among primigravidae in Indian population

2019 ◽  
Vol 8 (10) ◽  
pp. 3964
Author(s):  
Lavi Sindhu ◽  
Bindoo Yadav ◽  
Aruna Batra
Keyword(s):  
Early Pregnancy ◽  
Indian Population ◽  
Chlamydia Pneumoniae ◽  
Igg Antibodies ◽  
Interventional Study ◽  
Low Birth Weight Babies ◽  
Elisa Technique ◽  
Effect Of Treatment ◽  
Inflammatory Changes ◽  
Oral Azithromycin

Background: Preeclampsia (PE) is a multifactorial disease that might be caused by a concurrent or preceding inflammatory stimulus. Inflammatory changes similar to those reported in chronic Chlamydia pneumoniae infection are seen in PE. It is suggested that persistent or chronic Chlamydia pneumoniae infection might have a role in the pathogenesis of PE and antichlamydial treatment in early pregnancy may prevent reactivation of infection and hence the development of preeclampsia.Methods: This randomized interventional study was conducted to determine the prevalence of C.pneumoniae IgG seropositivity in early pregnancy, its association with PE and the effect of treatment with oral azithromycin. A total of 330 primigravidae included in the study were followed up till delivery. C.pneumoniae IgG antibodies measured by ELISA technique at 14-20 weeks of gestation revealed seropositivity in 32.4%. These women were at higher risk of developing severe PE (odds’ ratio 3.2) as compared to the C. pneumoniae seronegative cases.Results: Treatment with oral azithromycin resulted in reduction in the occurrence of PE amongst the C.pneumoniae seropositive cases; as well as significant reduction in the incidence of low birth weight babies in the C.pneumonie seropositive group (p<0.001, ARR= 0.204).Conclusions: Pregnant women who were C.pneumonia IgG seropositive are at higher risk of developing severe preeclmapsia as compared to the C.pneumoniae seronegative cases. This association needs to be further evaluated.

scholarly journals Advances in the Treatment of Yaws

2018 ◽  
Vol 3 (3) ◽  
pp. 92 ◽  
Author(s):  
Michael Marks
Keyword(s):  
Soft Tissues ◽  
Central Africa ◽  
Standard Of Care ◽  
World Health ◽  
South East Asia ◽  
The Pacific ◽  
West And Central Africa ◽  
Resistance To Penicillin ◽  
Health Organization ◽  
Oral Azithromycin

Yaws is one of the three endemic treponematoses and is recognised by the World Health Organization as a neglected tropical disease. Yaws is currently reported in 15 countries in the Pacific, South-East Asia, West and Central Africa, predominantly affects children, and results in destructive lesions of the skin and soft tissues. For most of the twentieth century penicillin-based treatment was the standard of care and resistance to penicillin has still not been described. Recently, oral azithromycin has been shown to be an effective treatment for yaws, facilitating renewed yaws eradication efforts. Resistance to azithromycin is an emerging threat and close surveillance will be required as yaws eradication efforts are scaled up globally.

scholarly journals Azithromycin Resistance and Its Mechanism in Neisseria gonorrhoeae Strains in Hyogo, Japan

2015 ◽  
Vol 59 (5) ◽  
pp. 2695-2699 ◽  
Author(s):  
Katsumi Shigemura ◽  
Kayo Osawa ◽  
Makiko Miura ◽  
Kazushi Tanaka ◽  
Soichi Arakawa ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Gene Mutations ◽  
Statistical Correlation ◽  
Deletion Mutation ◽  
23S Rrna ◽  
Oral Drugs ◽  
Content Type ◽  
Group 12 ◽  
Domain V ◽  
Oral Azithromycin

ABSTRACTTherapeutic options are limited forNeisseria gonorrhoeaeinfection, especially for oral drugs. The purpose of this study was to investigate the susceptibility ofN. gonorrhoeaeto oral azithromycin (AZM) and the correlation between AZM resistance-related gene mutations and MIC. We examined the AZM MICs of clinical strains ofN. gonorrhoeae, sequenced the peptidyltransferase loop in domain V of 23S rRNA, and investigated the statistical correlation between AZM MIC and the presence and number of the mutations. Among 59N. gonorrhoeaestrains, our statistical data showed that a deletion mutation was seen significantly more often in the higher-MIC group (0.5 μg/ml or higher) (35/37; 94.6%) than in the lower-MIC group (0.25 μg/ml or less) (4/22; 18.2%) (P< 0.0001). However, a mutation of codon 40 (Ala→Asp) in themtrRgene (helix-turn-helix) was seen significantly more often in the lower-MIC group (12/22; 54.5%) (P< 0.0001). InN. gonorrhoeaemultiantigen sequence typing (NG-MAST) analyses, ST4777 was representative of the lower-MIC group and ST1407, ST6798, and ST6800 were representative of the higher-MIC group. NG-MAST type 1407 was detected as the most prevalent type in AZM-resistant or -intermediate strains, as previously described. In conclusion, a deletion mutation in themtrRpromoter region may be a significant indicator for higher MIC (0.5 μg/ml or higher). ST4777 was often seen in the lower-MIC group, and ST1407, ST6798, and ST6800 were characteristic of the higher-MIC group. Further research with a greater number of strains would help elucidate the mechanism of AZM resistance inN. gonorrhoeaeinfection.

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