Incorrect Wording in: Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women: The Reynolds Risk Score

Background. CRP and family history independently associate with future cardiovascular events and have been incorporated into risk prediction models for women (the Reynolds Risk Score for women). However, no cardiovascular risk prediction algorithm incorporating these variables currently exists for men. Methods. Among 10,724 initially healthy American non-diabetic men who were followed prospectively for incident cardiovascular events over a median period of 10.8 years, we developed a cardiovascular risk prediction model that included hsCRP and parental history of myocardial infarction before age 60 years, and compared model fit, discrimination, and reclassification to prediction models limited to age, blood pressure, smoking, total cholesterol, and high-density lipoprotein cholesterol. Results. 1,294 cardiovascular events accrued during study follow-up. Predictive models incorporating hsCRP and parental history (the Reynolds Risk Score for men) had better global fit (P<0.001), a superior (lower) Bayes Information Criterion (BIC)(23008 vs 23048), and larger C-indexes (0.708 vs 0.699, P < 0.001) than did predictive models without these variables. For the endpoint of all cardiovascular events, the Reynolds Risk Score for men reclassified 17.8 percent of the study population into higher- or lower-risk categories with markedly improved accuracy among those reclassified. In models based on the ATP-III preferred endpoint of coronary heart disease and limited to men not taking lipid-lowering therapy, 16.7 percent of the study population were reclassified to higher- or lower-risk groups, again with significantly improved global fit (P<0.001), smaller BIC (13870 vs 13891), larger C-index (0.714 vs 0.704, P < 0.001), and almost perfect accuracy among those reclassified (99.9 percent). For this model, NRI was 8.4 percent and CNRI 15.8 percent (both P-values < 0.001). Conclusion. We developed an improved global risk prediction algorithm for men incorporating hsCRP and parental history that should allow better targeting of preventive therapies to maximize benefit while minimizing toxicity and cost.

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The Use of Reynolds Risk Score in Cardiovascular Risk Assessment in Apparently Healthy Bosnian Men and Women: Cross-Sectional Study

Recent Advances in Cardiovascular Risk Factors ◽

10.5772/39018 ◽

2012 ◽

Author(s):

Asija Zairagi

Keyword(s):

Risk Assessment ◽

Cardiovascular Risk ◽

Risk Score ◽

Cross Sectional Study ◽

Sectional Study ◽

Cardiovascular Risk Assessment ◽

Cross Sectional ◽

Men And Women ◽

Reynolds Risk Score ◽

Apparently Healthy

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The Reynolds Risk Score: improved accuracy for cardiovascular risk prediction in women?

Nature Clinical Practice Cardiovascular Medicine ◽

10.1038/ncpcardio0913 ◽

2007 ◽

Vol 4 (7) ◽

pp. 366-367 ◽

Cited By ~ 10

Author(s):

Nanette K Wenger

Keyword(s):

Cardiovascular Risk ◽

Risk Prediction ◽

Risk Score ◽

Cardiovascular Risk Prediction ◽

Improved Accuracy ◽

Reynolds Risk Score

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Assessment of cardiovascular risk in patients with crystal-induced arthritides and rheumatoid arthritis by the ATP III and Reynolds Risk Score

Rheumatology Science and Practice ◽

10.47360/1995-4484-2020-512-519 ◽

2020 ◽

Vol 58 (5) ◽

pp. 512-519

Author(s):

M. S. Eliseev ◽

A. M. Novikova ◽

O. V. Zhelyabina ◽

E. V. Gerasimova ◽

E. V. Ilyinykh ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Cardiovascular Risk ◽

High Risk ◽

Risk Score ◽

Control Method ◽

High Density Lipoproteins ◽

Control Group ◽

Crystal Deposition ◽

Very High ◽

Reynolds Risk Score

Cardiovascular risk (CVR) in patients with calcium pyrophosphate crystal deposition disease (CPPD) has not been studied, and the optimal method for assessing it has not been established yet.Objective: Evaluation of CVR and comparison of results using Adult Treatment Panel III (ATP III) and Reynolds Risk Score (RRS) scales in patients with CPPD, gout, rheumatoid arthritis (RA) and in the control group.Materials and methods: Cross-sectional, single-center study performed by case-control method. There are 42 patients with CPPD in main group, 42 patients with gout and RA in the comparison groups are, 42 healthy volunteers in the control group. The survey included measurements of anthropometric measures, blood pressure (BP), serum glucose, creatinine, cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), C-reactive protein (CRP). CVR was assessed on ATP III and RRS scales, comparison of its evaluation results was carried out between groups and between scales within groups.Results and discussion: Most of the parameters in the compared groups did not differ. However, HDL CS levels were significantly higher in patients with CPPD and in the control group than in RA and gout (p<0.05). In addition, in patients with gout and RA, systolic BP was higher than in CPPD and in control (p<0.05).CRP in CPPD was lower than in gout and RA and was not significantly different from this indicator in the control group. Its median was 3.8 [1.0; 12.4], 8.5 [4.1; 12.9] (р <0.05), 8.6 [4.1; 20.6] (р<0.05), 1.5 [0.8; 2.6] mg/l (p>0.05). The CRP > 5 mg/L in CPPD and in the control group was greater than in RA (p<0.05) and gout (p<0.05), but CRP≥5 mg/L was determined in 18 patients (43%) with CPPD and only in 3 (7%) people in the control group (p<0.05). A high and very high risk of cardiovascular disease (CVD) on the ATP III scale in CPPD was noted in 5 (12%) in gout – in 7 (17%), in RA – in 9 (21%) and in the control group – in 8 (19%) cases. Its frequency in all groups was comparable.A high and very high risk of CVD for RRS was identified in 9 (21%), 14 (33%), 12 (29%) and 7 (17%) cases, respectively.Conclusions: CVR under CPPD, RA and gout is comparable and quite high. The RRS scale may be a more objective method of assessing CVD risk in patients with CPPD, gout and RA.

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