Human-BasedIn VitroBrain Endothelial Cell Models

2015 ◽  
pp. 238-273
Author(s):  
Hannah K. Wilson ◽  
Eric V. Shusta
Keyword(s):  
Endothelial Cell ◽  
Cell Models

scholarly journals The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alina Klems ◽  
Jos van Rijssel ◽  
Anne S. Ramms ◽  
Raphael Wild ◽  
Julia Hammer ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Large Diameter ◽  
Small Diameter ◽  
Focal Adhesions ◽  
Cell Periphery ◽  
Vegf Receptor ◽  
Cell Models ◽  
Vegf Signaling ◽  
Arterial Lumen

Abstract Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery with a small diameter into a large caliber artery with a sizeable diameter occurs upon the blood flow driven change in number and shape of endothelial cells lining the arterial lumen. Here, using zebrafish embryos and endothelial cell models, we describe an alternative, flow independent model, involving enlargement of arterial endothelial cells, which results in the formation of large diameter arteries. Endothelial enlargement requires the GEF1 domain of the guanine nucleotide exchange factor Trio and activation of Rho-GTPases Rac1 and RhoG in the cell periphery, inducing F-actin cytoskeleton remodeling, myosin based tension at junction regions and focal adhesions. Activation of Trio in developing arteries in vivo involves precise titration of the Vegf signaling strength in the arterial wall, which is controlled by the soluble Vegf receptor Flt1.

scholarly journals Effect of heat stress on blood-brain barrier integrity in iPS cell-derived microvascular endothelial cell models

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222113 ◽  
Author(s):  
Tomoko Yamaguchi ◽  
Kentaro Shimizu ◽  
Yasuhiro Kokubu ◽  
Misae Nishijima ◽  
Shuko Takeda ◽  
...  
Keyword(s):  
Heat Stress ◽  
Endothelial Cell ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Microvascular Endothelial Cell ◽  
Cell Models ◽  
Ips Cell ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

Antioxidant activity of supercritical carbon dioxide extracts of Salvia desoleana on two human endothelial cell models

2012 ◽  
Vol 46 (1) ◽  
pp. 354-359 ◽  
Author(s):  
Anna Maria Posadino ◽  
Maria Cristina Porcu ◽  
Bruno Marongiu ◽  
Annalisa Cossu ◽  
Alessandra Piras ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Antioxidant Activity ◽  
Endothelial Cell ◽  
Supercritical Carbon Dioxide ◽  
Human Endothelial Cell ◽  
Cell Models ◽  
Supercritical Carbon

scholarly journals Culture and detection of primary cilia in endothelial cell models

Cilia ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Yi Chung Lim ◽  
Sue R. McGlashan ◽  
Michael T. Cooling ◽  
David S. Long
Keyword(s):  
Endothelial Cell ◽  
Primary Cilia ◽  
Cell Models

Computational fluid mechanical simulation of the deformation and the alignment of the cultured endothelial cell models

Biorheology ◽  
1996 ◽  
Vol 33 (4-5) ◽  
pp. 414
Author(s):  
T YAMAGUCHI ◽  
Y YAMAMOTO
Keyword(s):  
Endothelial Cell ◽  
Cell Models ◽  
Mechanical Simulation

scholarly journals Erratum: Puscas, I.; et al. IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening. Pharmaceutics 2019, 11, 587

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 514
Author(s):  
Ina Puscas ◽  
Florian Bernard-Patrzynski ◽  
Martin Jutras ◽  
Marc-André Lécuyer ◽  
Lyne Bourbonnière ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Mouse Brain ◽  
Drug Screening ◽  
Brain Endothelial Cell ◽  
Cell Models

The authors wish to make the following corrections to this paper [...]

Sign in / Sign up

Export Citation Format

Share Document