Blood lipid abnormalities

2021 ◽  
pp. 162-167
Keyword(s):  
Blood Lipid ◽  
Lipid Abnormalities

scholarly journals Application of Artificial Neural Network Method as A Detection of Blood Fat Disorders in Images of Complete Blood Examination

2021 ◽  
Vol 2 (2) ◽  
pp. 27
Author(s):  
Catharina Natasa Bella Fortuna ◽  
Franky Chandra Satria Arisgraha, S.T., M.T. ◽  
Puspa Erawati
Keyword(s):  
Neural Network ◽  
Image Processing ◽  
Artificial Neural Network ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Lipid ◽  
Blood Examination ◽  
Network Method ◽  
Artificial Neural Network Method ◽  
Lipid Abnormalities

Based on various epidemiological studies, it is stated that blood lipids are the main risk factor for atherosclerosis that leads to coronary heart disease. In patients with blood lipid disorders, red blood cells undergo deformability so that their shape is flatter than normal red blood cells, which are round. The research entitled Application of Artificial Neural Network Method as Detection of Blood Fat Abnormalities in Image of Complete Blood Examination Results was conducted to help facilitate laboratory examinations. This research hopes that it will provide appropriate early detection to support the expert diagnosis. This research consists of two stages. The first stage is digital image processing to obtain area, perimeter, and eccentricity features. These three features will be used as input to the Backpropagation Neural Network program as the second stage. At this stage, blood lipid abnormalities are detected from features that have been obtained from image processing. The accuracy of detecting blood lipid abnormalities with ANN Backpropagation is 85%.

Effects of a novel antihyperlipidemic agent, S-2E, on the blood lipid abnormalities in homozygous WHHL rabbits

Metabolism ◽  
2004 ◽  
Vol 53 (5) ◽  
pp. 680-685 ◽  
Author(s):  
K Ohmori ◽  
H Yamada ◽  
A Yasuda ◽  
A Yamamoto ◽  
N Matsuura ◽  
...  
Keyword(s):  
Blood Lipid ◽  
Lipid Abnormalities

Trends in obesity and blood lipid abnormalities in school‐age children in Japan

2020 ◽  
Author(s):  
Hisako Tanaka ◽  
Naho Morisaki ◽  
Aurelie Piedvache ◽  
Shohei Harada ◽  
Kevin Y. Urayama
Keyword(s):  
Blood Lipid ◽  
School Age Children ◽  
School Age ◽  
Lipid Abnormalities

Abstract P151: Comparison of Standard Definitions and Sagittal Abdominal Diameter as a Measure of Excess Adiposity When Defining Metabolic Syndrome in Adolescents

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Symielle A Gaston ◽  
Nicolle S Tulve ◽  
Tekeda F Ferguson
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Clinical Symptoms ◽  
Fasting Blood Glucose ◽  
Blood Lipid ◽  
Sagittal Abdominal Diameter ◽  
High Waist Circumference ◽  
Effective Interventions ◽  
Definition Of ◽  
Lipid Abnormalities

Introduction: Metabolic syndrome (MetS) is the cluster of several clinical symptoms that together represent the strongest risk factor for cardiovascular disease. The prevalence of MetS in adolescents is difficult to estimate given that there are several, but no agreed upon definition of MetS for this age group. It is important to estimate MetS and identify at-risk adolescents early in order to provide effective interventions prior to the development of diabetes and coronary heart disease. Objective: Study objectives are to: (1) estimate the prevalence of MetS in U.S. adolescents using three widely adopted definitions and (2) compare changes in prevalence of MetS when utilizing sagittal abdominal diameter (SAD) as a component of MetS. Methods: Data from U.S. adolescents ages 12-19 years (N=970) in the NHANES (2011-2014) were analyzed. MetS standard definitions developed by Cook et al. (2003), deFerranti et al. (2007), and the International Disease Federation (IDF, 2007) were applied to estimate the sex-stratified, weighted prevalence of MetS and its individual components (i.e., high waist circumference (WC), hypertension, blood lipid abnormalities, and high fasting blood glucose (FBG)). The definitions were modified by substituting SAD for WC, and weighted MetS prevalence was re-estimated. Results: Regardless of gender and definition, abnormal blood lipids and high WC were the most prevalent MetS components. For both sexes, estimated prevalence of components varied greatly by definition (e.g., boys’ prevalence of high fasting blood glucose: IDF-27.2% vs. Cook and deFerranti-both 2.7%). MetS prevalence in boys using standard and SAD-modified definitions were 4.5% and 5.0%; 10.6% and 9.4%; and 4.6% and 3.3% for the Cook, deFerranti, and IDF definitions, respectively. Among girls, the standard-defined and SAD-modified MetS prevalence were 2.4% and 2.4%; 8.5% and 8.2%; and 4.3% and 2.8% for the Cook, deFerranti, and IDF definitions, respectively. Conclusions: Though the most prevalent MetS components were similar, the estimated prevalence values of individual components varied greatly across MetS definitions. With the risk of false positives, the deFerranti definition of MetS may identify the greatest number of adolescents at potential risk for MetS. Cook and deFerranti definitions may miss the identification of adolescents who could benefit from additional health promotion programs. Compared to WC, use of SAD resulted in similar yet slightly attenuated estimated MetS prevalence.

scholarly journals Dyslipidemia: Current Perspectives and Implications for Clinical Practice

2021 ◽  
Author(s):  
Sanja Klobučar Majanović ◽  
Olga Cvijanović Peloza ◽  
Dijana Detel ◽  
Gordana Kenđel Jovanović ◽  
Miro Bakula ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Practice ◽  
Ldl Cholesterol ◽  
Blood Lipid ◽  
Statin Treatment ◽  
Cvd Risk ◽  
Increased Risk ◽  
Lipid Abnormalities ◽  
Current Guidelines

Dyslipidemia refers to a broad spectrum of various genetic and acquired disorders that affect blood lipid levels and largely contribute to global cardiovascular disease burden. Consistent evidence from epidemiological and clinical studies, supports the key role of the circulating LDL-cholesterol and other apoB containing lipoproteins in atherogenesis. All ApoB-containing lipoproteins with size less than 70 nm can cross the endothelial barrier, particularly in the presence of endothelial dysfunction. Uptake and accumulation of apoB-containing lipoproteins in the arterial wall is a critical initiating event in the development of atherosclerosis. Statin treatment, targeting LDL cholesterol reduction, remains the cornerstone of dyslipidemia management. There are abundant data supporting the concept of ‘the lower LDL-C, the better’ in the primary and secondary cardiovascular disease prevention. This chapter provides an overview of the key insights into the lipid abnormalities associated with an increased risk of CV events particulary in the context of dyslipidemia management in everyday clinical practice. Understanding the important role that metabolic derangements play in the pathogenesis of atherosclerosis pave the way for stronger implementation of current guidelines for CVD risk assessment and prevention.

Effects of the Tibetan herbal preparation PADMA 28 on blood lipids and lipid oxidisability in subjects with mild hypercholesterolaemia

VASA ◽  
2005 ◽  
Vol 34 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Brunner-La Rocca ◽  
Schindler ◽  
Schlumpf ◽  
Saller ◽  
Suter
Keyword(s):  
Endothelial Dysfunction ◽  
Blood Lipids ◽  
Ex Vivo ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Tibetan Medicine ◽  
Double Blind ◽  
Intraarterial Infusion ◽  
Padma 28

Background: Previous studies showed an anti-atherosclerotic effect of PADMA 28, an herbal formula based on Tibetan medicine. As the mechanisms of action are not fully understood, we investigated whether PADMA 28 may lower blood lipids and lipid oxidisability, and affect early endothelial dysfunction. Patients and methods: Sixty otherwise healthy subjects with total cholesterol ≥5.2 mmol/l and < 8.0 mmol/l were randomly assigned to placebo or PADMA 28, 3 x 2 capsules daily, for 4 weeks (double-blind). Blood lipids (total, LDL-, and HDL-cholesterol, triglycerides, Apo-lipoprotein A1 and B) and ex vivo lipid oxidisability were measured before and after treatment. In a subset of 24 subjects, endothelial function was assessed using venous occlusion plethysmography with intraarterial infusion of acetylcholine. Isolated LDL and plasma both untreated and pre-treated with PADMA 28 extract were oxidised by the radical generator AAPH. Conjugated diene formation was measured at 245 nm. Results: Blood lipids did not change during the study in both groups. In contrast to previous reports in mild hypercholesterolaemia, no endothelial dysfunction was seen and, consequently, was not influenced by therapy. Ex vivo blood lipid oxidisability was significantly reduced with PADMA 28 (area under curve: 5.29 ± 1.62 to 4.99 ± 1.46, p = 0.01), and remained unchanged in the placebo group (5.33 ± 1.88 to 5.18 ± 1.78, p > 0.1). This effect persisted one week after cessation of medication. In vitro experiments confirmed the prevention of lipid peroxidation in the presence of PADMA 28 extracts. Persistent protection was also seen for LDL isolated from PADMA 28-pretreated blood after being subjected to rigorous purification. Conclusions: This study suggests that the inhibition of blood lipid oxidisability by PADMA 28 may play a role in its anti-atherosclerotic effect.

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