Cost-Effectiveness Model for Evaluating New Diagnostic Tests in the Evaluation of Patients With Inflammatory Arthritis at Risk of Having Rheumatoid Arthritis

2016 ◽  
Vol 68 (7) ◽  
pp. 927-935 ◽  
Author(s):  
Jolanda J. Luime ◽  
Leander R. Buisman ◽  
Mark Oppe ◽  
Johanna M. W. Hazes ◽  
Maureen P. M. H. Rutten-van Mölken
Author(s):  
Karim Raza ◽  
Catherine McGrath ◽  
Laurette van Boheemen ◽  
Dirkjan van Schaardenburg

The typical evolution of rheumatoid arthritis (RA) is that a person, with genetic risk factors, develops autoantibodies and subclinical inflammation under relevant environmental influences. There are indications that the primary site of the pathology is at mucosal surfaces (e.g. in the gums, lungs, and/or the gut), after which the disease translocates to the joints. Preclinical RA can be defined at the phase during which no clinically apparent features are present (i.e. no symptoms of inflammatory arthritis or clinically apparent joint swelling) but during which RA related biologic derangements such as the presence of autoantibodies are present. This chapter presents an overview of the risk factors, stages, and events occurring during the pre-RA phase. A better understanding of the factors involved will enable more accurate prediction of RA at the individual level and selection of high-risk individuals for inclusion in preventive studies. Several pharmacologic and non-pharmacologic studies aiming to prevent or delay the onset of RA in at-risk individuals are currently underway. It is hoped that such interventions in the pre-RA and indeed in the preclinical-RA phases will allow us to reduce the risk of RA and prevent RA developing in at least a proportion of at-risk patients.


Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 752
Author(s):  
Andrea Di Matteo ◽  
Davide Corradini ◽  
Kulveer Mankia

The identification of biomarkers that help identify individuals at imminent risk of progression to rheumatoid arthritis (RA) is of crucial importance for disease prevention. In recent years, several studies have highlighted the value of musculoskeletal (MSK) ultrasound (US) in predicting progression to inflammatory arthritis (IA) in individuals ‘at-risk’ of RA. These studies have highlighted the following main aspects: first, in RA-related autoantibody-positive individuals, MSK symptoms seem to develop before ‘sub-clinical’ joint inflammation occurs on US. Second, the detection of ‘sub-clinical’ synovitis (and/or bone erosions) greatly increases the risk of IA development in these ‘at-risk’ individuals. US has a potential key role for better understanding the ‘pre-clinical’ stages in individuals ‘at-risk’ of RA, and for the early identification of those individuals at high risk of developing IA. Further research is needed to address questions on image analysis and standardization. In this review, we provide an overview of the most relevant studies which have investigated the value of US in the prediction of RA development in individuals ‘at-risk’ of RA who have MSK symptoms, but no clinical evidence of IA. We highlight recent insights, limitations, and future perspectives of US use in this important population.


2016 ◽  
Vol 18 (1) ◽  
Author(s):  
Leander R. Buisman ◽  
Jolanda J. Luime ◽  
Mark Oppe ◽  
Johanna M. W. Hazes ◽  
Maureen P. M. H. Rutten-van Mölken

2015 ◽  
Vol 18 (7) ◽  
pp. A358-A359
Author(s):  
LR Buisman ◽  
JJ Luime ◽  
M Oppe ◽  
JM Hazes ◽  
MP Rutten-van Mölken

2020 ◽  
Vol 23 ◽  
pp. S595
Author(s):  
S. Sadler ◽  
I. Jacob ◽  
O. Darlington ◽  
E. Still ◽  
J. Gordon ◽  
...  

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 159.1-159
Author(s):  
C. M. T. Madsen ◽  
J. Reffstrup Christensen ◽  
A. Bremander ◽  
J. Primdahl

Background:People with inflammatory arthritis (IA), i.e. rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis, often experience low work ability and up to 38% lose their job during the first years after being diagnosed with IA (1). As a result, people with IA have a higher risk of job loss and permanent exclusion from the labor market than people without IA (1, 2). Work-related rehabilitation is complex and encompass a variety of interventions which aim to reduce barriers to maintain work and improve work ability. Unfortunately, positive results from work-related rehabilitation is scarce (3), why a better understanding of the challenges people at risk for job loss experience is needed to develop relevant interventions.Objectives:To explore perceived challenges and need for support to remain at work among people with IA who are at risk of job loss.Methods:A qualitative explorative design based on a hermeneutic approach was applied. Outpatients with IA who considered themselves at risk for long-term job loss, were recruited at the Danish Hospital for Rheumatic Diseases. An interview guide was developed based on earlier results from a systematic review and qualitative studies in close cooperation with three patient research partners. Individual semi-structured interviews were performed from December 2019 to May 2020.Results:Eleven women and four men with IA (aged 36-68 years) were interviewed. The participants were employed full time, part time or on sick leave. From the analysis, a main theme ‘Balancing work as a part of everyday life’ and four sub-themes emerged: 1) Working despite challenges, 2) Prioritizing energy for work, 3) Fatigue affects everything and 4) Need for support. To be able to work was very important to all participants. In general, they were stretching their limits, had concerns about maintaining their job and they used different strategies to deal with the challenges they met at work. Flexibility at work in every possible way and support from employers and co-workers were the main needs to be able to remain at work.Conclusion:Overall, patients with IA prioritized to keep working, but experienced challenges with balancing their work and energy in everyday life. They need support and flexibility at work to be able to remain at work.References:[1]Sokka T, Kautiainen H, Pincus T, Verstappen SMM, Aggarwal A, Alten R, et al. Work disability remains a major problem in rheumatoid arthritis in the 2000s: Data from 32 countries in the QUEST-RA Study. Arthritis Research and Therapy. 2010;12(2):R42-R.[2]Hansen SM, Hetland ML, Pedersen J, Ostergaard M, Rubak TS, Bjorner JB. Effect of rheumatoid arthritis on longterm sickness absence in 1994-2011: A danish cohort study. Journal of Rheumatology. 2016;43(4):707-15.[3]Madsen CMT, Kjaer, S., Primdahl, J., Christensen, J. R., & von Bulow, C. A SYSTEMATIC REVIEW OF JOB LOSS PREVENTION INTERVENTIONS FOR PERSONS WITH INFLAMMATORY ARTHRITIS. Annals of the rheumatic diseases, 79(Suppl 1) 916-917 [FRI0624-HPR]2020.Disclosure of Interests:None declared


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