Magnetically Navigated Protein Transduction In Vivo using Iron Oxide‐Nanogel Chaperone Hybrid

AbstractThe purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of an external static magnetic field for targeting SPIONs in gliomas. A search of PubMed, Cochrane Library, Scopus, and Web of Science databases identified 228 studies, 23 of which were selected based on inclusion criteria and predetermined exclusion criteria. The articles were analyzed by physicochemical characteristics of SPIONs used, cell types used for tumor induction, characteristics of experimental glioma models, magnetic targeting technical parameters, and analysis method of process efficiency. The study shows the highlights and importance of magnetic targeting to optimize the magnetic targeting process as a therapeutic strategy for gliomas. Regardless of the intensity of the patterned magnetic field, the time of application of the field, and nanoparticle used (commercial or synthesized), all studies showed a vast advantage in the use of magnetic targeting, either alone or in combination with other techniques, for optimized glioma therapy. Therefore, this review elucidates the preclinical and therapeutic applications of magnetic targeting in glioma, an innovative nanobiotechnological method.

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Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: Clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.20057 ◽

2004 ◽

Vol 20 (1) ◽

pp. 16-24 ◽

Cited By ~ 79

Author(s):

Martin Rausch ◽

Peter Hiestand ◽

Carolyn A. Foster ◽

Diana R. Baumann ◽

Catherine Cannet ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Iron Oxide ◽

Magnetic Resonance ◽

Superparamagnetic Iron Oxide ◽

Clinical Implications ◽

Resonance Imaging ◽

Autoimmune Encephalomyelitis ◽

Ultrasmall Superparamagnetic Iron Oxide ◽

Experimental Autoimmune

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In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures

Experimental Neurology ◽

10.1016/j.expneurol.2005.08.021 ◽

2006 ◽

Vol 197 (2) ◽

pp. 301-308 ◽

Cited By ~ 14

Author(s):

Tianfu Li ◽

Yongfeng Fan ◽

Yumin Luo ◽

Baoguo Xiao ◽

Chuanzhen Lu

Keyword(s):

Fusion Protein ◽

Neuronal Death ◽

Protein Transduction ◽

Protein Transduction Domain ◽

Ring Fusion ◽

In Vivo Delivery

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In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2020-3139 ◽

2020 ◽

Vol 6 (3) ◽

pp. 543-546

Author(s):

Michael Fink ◽

Stefan J. Rupitsch ◽

Helmut Ermert ◽

Stefan Lyer

Keyword(s):

Iron Oxide ◽

Magnetic Nanoparticles ◽

Drug Targeting ◽

Imaging Technique ◽

Small Animal ◽

Magnetic Drug Targeting ◽

Oxide Nanoparticles ◽

Medical Procedures ◽

First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

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A Review on Green Synthesis and Applications of Iron Oxide Nanoparticles

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2021.19285 ◽

2021 ◽

Vol 21 (12) ◽

pp. 5812-5834

Author(s):

Rachana Yadwade ◽

Saili Kirtiwar ◽

Balaprasad Ankamwar

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Aqueous System ◽

Oxide Nanoparticles ◽

Plant Parts ◽

Different Types ◽

Removal Of Heavy Metals ◽

Biological Sources ◽

Different Sources

Bio-fabrication of iron oxide nanoparticles by using different sources of plants, plant parts and microbial cells have become a great topic of interest nowadays due to its eco-friendly nature. The stabilizing and capping agents in biological sources are biocompatible, stable and non-toxic which make its use beneficial for various biomedical applications. The bacteria are able to utilize metal ions and convert them into their respective nanoparticles by secreting different biomolecules. The plants and plant parts contain different types of phytochemicals which play a key role in synthesis and bio-fabrication of nanoparticles. Iron oxide nanoparticles are known to have various applications in the fields of medicine, environment etc. This review summarizes the applications of iron oxide nanoparticles as antimicrobial agent, drug delivery agent, material for removal of heavy metals and dyes from aqueous system etc. Due to these wide applications of iron oxide nanoparticles its demand in various fields is increasing considerably. This review describes different approaches which are used for biosynthesis of iron oxide nanoparticles and their applications. The review also summarizes about the surface modification strategies of iron oxide nanoparticles by using different polymers, polyelectrolytes which can be used for in-vivo applications.

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Folic Acid Functionalized Chlorin e6-Superparamagnetic Iron Oxide Nanocarriers as a Theranostic Agent for MRI-Guided Photodynamic Therapy

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3021 ◽

2021 ◽

Vol 17 (2) ◽

pp. 205-215

Author(s):

Zhenbo Sun ◽

Mingfang Luo ◽

Jia Li ◽

Ailing Wang ◽

Xucheng Sun ◽

...

Keyword(s):

Photodynamic Therapy ◽

Folic Acid ◽

Iron Oxide ◽

Near Infrared ◽

Biological Fluids ◽

Superparamagnetic Iron Oxide ◽

Chlorin E6 ◽

Theranostic Agent

Imaging-guided cancer theranostic is a promising strategy for cancer diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, is limited by the poor solubility and dispersion of photosensitizers (PS) in biological fluids. Herein, it is demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared by conjugated with Chlorin e6 (Ce6) and modified with folic acid (FA) on the surface, can be used as versatile drug delivery vehicles for effective PDT. The nanoparticles are great carriers for photosensitizer Ce6 with an extremely high loading efficiency. In vitro fluorescence imaging and in vivo magnetic resonance imaging (MRI) results indicated that SCFs selectively accumulated in tumor cells. Under near-infrared laser irradiation, SCFs were confirmed to be capable of inducing low cell viability of RM-1 cells In vitro and displaying efficient tumor ablation with negligible side effects in tumor-bearing mice models.

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