Light Irradiation of Gold Nanoparticles Toward Advanced Cancer Therapeutics

2019 ◽  
Vol 3 (1) ◽  
pp. 1900153 ◽  
Author(s):  
Ana Amendoeira ◽  
Lorenzo Rivas García ◽  
Alexandra R. Fernandes ◽  
Pedro V. Baptista
Keyword(s):  
Gold Nanoparticles ◽  
Advanced Cancer ◽  
Cancer Therapeutics ◽  
Light Irradiation

scholarly journals Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 261
Author(s):  
Wei Mao ◽  
Sol Lee ◽  
Ji Un Shin ◽  
Hyuk Sang Yoo
Keyword(s):  
Gold Nanoparticles ◽  
Transfection Efficiency ◽  
Cancer Therapeutics ◽  
Atom Transfer ◽  
Layer By Layer ◽  
Dependent Manner ◽  
Metallic Particles ◽  
Anti Cancer

Surface initiated atom transfer radical polymerization (SI-ATRP) documented a simple but efficient technique to grow a dense polymer layer on any surface. Gold nanoparticles (AuNPs) give a broad surface to immobilize sulfhyryl group-containing initiators for SI-ATRP; in addition, AuNPs are the major nanoparticulate carriers for delivery of anti-cancer therapeutics, since they are biocompatible and bioinert. In this work, AuNPs with a disulfide initiator were polymerized with sulfoethyl methacrylate by SI-ATRP to decorate the particles with anionic corona, and branched polyethyeleneimine (PEI) and siRNA were sequentially layered onto the anionic corona of AuNP by electrostatic interaction. The in vitro anti-cancer effect confirmed that AuNP with anionic corona showed higher degrees of apoptosis as well as suppression of the oncogene expression in a siRNA dose-dependent manner. The in vivo study of tumor-bearing nude mice revealed that mice treated with c-Myc siRNA-incorporated AuNPs showed dramatically decreased tumor size in comparison to those with free siRNA for 4 weeks. Furthermore, histological examination and gene expression study revealed that the decorated AuNP significantly suppressed c-Myc expression. Thus, we envision that the layer-by-layer assembly on the anionic brushes can be potentially used to incorporate nucleic acids onto metallic particles with high transfection efficiency.

Plasmonic resonance enhanced photoelectrochemical aptasensors based on g-C3N4/Bi2MoO6

2018 ◽  
Vol 54 (52) ◽  
pp. 7199-7202 ◽  
Author(s):  
Zhenli Qiu ◽  
Jian Shu ◽  
Dianping Tang
Keyword(s):  
Gold Nanoparticles ◽  
Surface Plasmon Resonance ◽  
Visible Light ◽  
Surface Plasmon ◽  
Visible Light Irradiation ◽  
Plasmon Resonance ◽  
Localized Surface Plasmon Resonance ◽  
Light Irradiation ◽  
Localized Surface Plasmon ◽  
Plasmonic Resonance

An in-depth exploration associated with localized surface plasmon resonance between g-C3N4/Bi2MoO6 and gold nanoparticles has been conducted for highly efficient photoelectrochemical aptasensors under ultraviolet and visible light irradiation.

Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention

Nanoscale ◽  
2014 ◽  
Vol 6 (20) ◽  
pp. 12026-12033 ◽  
Author(s):  
C. Yang ◽  
J. Uertz ◽  
D. Yohan ◽  
B. D. Chithrani
Keyword(s):  
Gold Nanoparticles ◽  
Radiation Dose ◽  
Hyperspectral Imaging ◽  
Anticancer Drug ◽  
Cellular Uptake ◽  
Imaging Technique ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Nuclear Targeting ◽  
First Time

A novel hyperspectral imaging technique is used to image GNPs: a combination of three peptides is used for efficient nuclear targeting and improved retention of GNPs targeted into the nucleus is shown for the first time. This is important for future cancer therapeutics as GNPs can be used as radiation dose enhancers and anticancer drug carriers.

scholarly journals Cytotoxicity of Biogenic Gold Nanoparticles against Lung Cancer Cell Line (A549): An Application Oriented Perspective

2018 ◽  
Author(s):  
Babita Jha ◽  
Kamal Prasad ◽  
Anal K. Jha
Keyword(s):  
Lung Cancer ◽  
Gold Nanoparticles ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cancer Therapeutics ◽  
Lung Cancer Cell Line ◽  
Piper Betle ◽  
Lung Cancer Cell ◽  
Vis Spectroscopy

The present work encompasses an application-oriented perspective to the possible employment of gold nanoparticles as nanomedicine in cancer therapeutics. The rationale of the work lies in the growing needs for assessment of advanced alternative treatment of cancer employing functionalized nanoparticles as nanomedicine. Gold nanoparticles fabricated via green chemistry methods by leaves of a time-honored medicinal plant, Piper betle were ascertained for their synthesis and properties under the umbrella of characterization of nanoparticles, through various techniques like UV-vis spectroscopy, FTIR spectroscopy, X-ray diffraction, and scanning electron microscopy. The cytotoxicity assay of well-characterized gold nanoparticles was monitored against lung cancer cell line (A549) by metabolic and imaging assays. MTT assay or the metabolic assay was performed for a range of nanoparticles’ concentrations. The results were promising and proved to be a leading-edge venture, envisaging the possibility of gold nanoparticles for cancer therapeutics.

scholarly journals Orientation of Chiral Schiff Base Metal Complexes Involving Azo-Groups for Induced CD on Gold Nanoparticles by Polarized UV Light Irradiation

Symmetry ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1094
Author(s):  
Nobumitsu Sunaga ◽  
Tomoyuki Haraguchi ◽  
Takashiro Akitsu
Keyword(s):  
Gold Nanoparticles ◽  
Schiff Base ◽  
Uv Light ◽  
Light Irradiation ◽  
Spatial Features ◽  
Dipole Interactions ◽  
Uv Light Irradiation ◽  
Linearly Polarized ◽  
Chiral Species ◽  
Schiff Base Metal Complexes

In this study, we report the synthesis, characterization, and chiroptical properties of azo-group-containing chiral salen type Schiff base Ni(II), Cu(II), and Zn(II) complexes absorbed on gold nanoparticles (AuNPs) of 10 nm diameters. Induced circular dichroism (CD) around the plasmon region from the chiral species weakly adsorbed on the surface of AuNP were observed when there were appropriate dipole–dipole interactions at the initial states. Spectral changes were also observed by not only cis-trans photoisomerization of azo-groups but also changes of orientation due to Weigert effect of azo-dyes after linearly polarized UV light irradiation. Spatial features were discussed based on dipole-dipole interactions mainly within an exciton framework.

Gold nanospheres and nanorods for anti-cancer therapy: comparative studies of fabrication, surface-decoration, and anti-cancer treatments

Nanoscale ◽  
2020 ◽  
Vol 12 (28) ◽  
pp. 14996-15020
Author(s):  
Wei Mao ◽  
Young Ju Son ◽  
Hyuk Sang Yoo
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Gold Nanospheres ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Irradiation Therapy ◽  
Surface Decoration

Various gold nanoparticles have been explored as cancer therapeutics because they can be widely engineered for use as efficient drug carriers and diagnostic agents, and in photo-irradiation therapy.

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