Synthesis and swelling properties of pH-sensitive hydrogels based on chitosan and poly(methacrylic acid) semi-interpenetrating polymer network

2005 ◽  
Vol 98 (4) ◽  
pp. 1720-1726 ◽  
Author(s):  
Shilan Chen ◽  
Mingzhu Liu ◽  
Shuping Jin ◽  
Yong Chen
Keyword(s):  
Methacrylic Acid ◽  
Polymer Network ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Swelling Properties

Fabrication and characterization of a novel semi-interpenetrating network hydrogel based on sodium carboxymethyl cellulose and poly(methacrylic acid) for oral insulin delivery

2020 ◽  
Vol 35 (1) ◽  
pp. 3-14
Author(s):  
Shunying Li ◽  
Zhiru Chen ◽  
Jun Wang ◽  
Libiao Yan ◽  
Tingting Chen ◽  
...  
Keyword(s):  
Oral Administration ◽  
Methacrylic Acid ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Insulin Delivery ◽  
Interpenetrating Polymer Network ◽  
Sodium Carboxymethyl Cellulose ◽  
Oral Insulin ◽  
Swelling Properties

In this research, pH-sensitive semi-interpenetrating polymer network hydrogels based on sodium carboxymethyl cellulose and poly(methacrylic acid) were synthesized using free radical polymerization and semi-interpenetrating polymer network approach for oral administration of insulin. The chemical structure and thermal stability of the hydrogels were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis measurements. The interior morphology was observed by scanning electron microscopy and the inner structure exhibited a porous honeycomb-like shape. The investigations on the swelling properties of hydrogels revealed their ability to response to pH value change. The in vitro release behavior of insulin was pH dependent and the release of insulin was much lower at pH 1.2 compared to pH 6.8. In vitro cytotoxicity assay indicated that the hydrogels were noncytotoxic to HeLa cells. A sustained reduction in blood glucose level was observed after oral administration of insulin-loaded hydrogel to diabetic rats at 75 IU/kg. These results indicated that the hydrogel would be a promising vehicle for oral insulin delivery systems.

Modulation in Sorption Dynamics of a pH‐Sensitive Interpenetrating Polymer Network (IPN)

2004 ◽  
Vol 41 (2) ◽  
pp. 211-230 ◽  
Author(s):  
A. K. Bajpai ◽  
J. Bajpai ◽  
Sandeep Shukla ◽  
R. A. Kulkarni
Keyword(s):  
Polymer Network ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Sorption Dynamics

scholarly journals ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

2019 ◽  
pp. 98-103
Author(s):  
Saruchi Sharma ◽  
VANEET KUMAR
Keyword(s):  
Drug Release ◽  
Polymer Network ◽  
Lateral Diffusion ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Ph Responsive ◽  
Gum Tragacanth ◽  
Swelling Capacity

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

Semi-interpenetrating Polymer Networks Containing Polysaccharides. I Xanthan/Lignin Networks

2007 ◽  
Vol 19 (5-6) ◽  
pp. 603-620 ◽  
Author(s):  
Irina Elena Raschip ◽  
Cornelia Vasile ◽  
Diana Ciolacu ◽  
Georgeta Cazacu
Keyword(s):  
Xanthan Gum ◽  
Polymer Network ◽  
Polymer Networks ◽  
Temperature Stability ◽  
Interpenetrating Polymer Networks ◽  
Interpenetrating Polymer Network ◽  
Helical Conformation ◽  
Swelling Properties ◽  
Food Ingredients ◽  
Swelling Rate

The polysaccharides are important materials in food, pharmaceutical, cosmetic and related biomedical applications. Xanthan gum is a microbial polysaccharide of great commercial significance. It is well known as one of the best thickening polymers due to its high intrinsic stiffness related to the helical conformation stabilized in the presence of excess salt. It is used in a wide variety of foods for a number of important reasons, including emulsion stabilization, temperature stability, compatibility with food ingredients, and its pseudoplastic rheological properties. Due to its properties in thickening aqueous solutions, as a dispersing agent, and stabilizer of emulsions and suspensions, xanthan gum is used in pharmaceutical formulations, cosmetics, and agricultural products, as well as in textile printing pastes, ceramic glazes, slurry explosive formulations, and rust removers. In this work the crosslinking of a mixture of xanthan and lignins in the presence of the epichlorohydrin, leading to superabsorbant hydrogels with high swelling rate in aqueous mediums, was studied. The swelling properties of these composite hydrogels were investigated. Three different types of lignin have been used namely: aspen wood lignin (L), annual fiber crop lignin (GL) and lignin epoxy-modified resin (LER). Semi-interpenetrating polymer network hydrogels in various ratios were prepared. The influence of gravimetric ratio between components of the semi-interpenetrating polymer networks, as well as the kinetics of water sorption will be discussed. The maximum swelling degree of the hydrogels and the swelling rate constant were determined as a function of the hydrogel's composition. It has been established that the nature of lignin significantly influences swelling process, the chemical modified lignin having a particular behavior.

Slow-Release Behaviors of Poly(vinyl alcohol)/Poly(N, N-diethylacrylamide-co-methacrylic acid) Semi-IPN Materials

2013 ◽  
Vol 709 ◽  
pp. 135-138 ◽  
Author(s):  
Xiao Qi Li ◽  
Nai Yan Zhang ◽  
Yang Xue Li ◽  
Hong Jin Li
Keyword(s):  
Methacrylic Acid ◽  
Vinyl Alcohol ◽  
Polymer Network ◽  
Ammonium Persulfate ◽  
Radical Copolymerization ◽  
Polymer Materials ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Porous Network ◽  
Free Radical Copolymerization

A series of semi-interpenetrating polymer materials of poly (vinyl alcohol)/poly (N, N-diethylacrylamide-co-methacrylic acid)(PVA/PDM) were synthesized by free radical copolymerization techniques and semi-interpenetrating polymer network techniques at room temperature with ammonium persulfate and N,N,N',N'-tetramethylethylene diamide as initiators and N,N'-methylenebisacrylamide as a crosslinker. The interior morphology by scanning electron microscopy (SEM) revealed that PVA introduced PDM materials have interconnected porous network structures. The release behaviors of the model drug, aminophylline, are found dependent on material composition and environmental temperature, which suggests that these materials have potential application as intelligent release carriers.

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