Silicone-based hydrogels prepared by interpenetrating polymer network synthesis: Swelling properties and confinements effects on the formation kinetics

The polysaccharides are important materials in food, pharmaceutical, cosmetic and related biomedical applications. Xanthan gum is a microbial polysaccharide of great commercial significance. It is well known as one of the best thickening polymers due to its high intrinsic stiffness related to the helical conformation stabilized in the presence of excess salt. It is used in a wide variety of foods for a number of important reasons, including emulsion stabilization, temperature stability, compatibility with food ingredients, and its pseudoplastic rheological properties. Due to its properties in thickening aqueous solutions, as a dispersing agent, and stabilizer of emulsions and suspensions, xanthan gum is used in pharmaceutical formulations, cosmetics, and agricultural products, as well as in textile printing pastes, ceramic glazes, slurry explosive formulations, and rust removers. In this work the crosslinking of a mixture of xanthan and lignins in the presence of the epichlorohydrin, leading to superabsorbant hydrogels with high swelling rate in aqueous mediums, was studied. The swelling properties of these composite hydrogels were investigated. Three different types of lignin have been used namely: aspen wood lignin (L), annual fiber crop lignin (GL) and lignin epoxy-modified resin (LER). Semi-interpenetrating polymer network hydrogels in various ratios were prepared. The influence of gravimetric ratio between components of the semi-interpenetrating polymer networks, as well as the kinetics of water sorption will be discussed. The maximum swelling degree of the hydrogels and the swelling rate constant were determined as a function of the hydrogel's composition. It has been established that the nature of lignin significantly influences swelling process, the chemical modified lignin having a particular behavior.

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Synthesis and Properties of pH-, Thermo-, and Salt-Sensitive Modified Poly(aspartic acid)/Poly(vinyl alcohol) IPN Hydrogel and Its Drug Controlled Release

BioMed Research International ◽

10.1155/2015/236745 ◽

2015 ◽

Vol 2015 ◽

pp. 1-12 ◽

Cited By ~ 8

Author(s):

Jingqiong Lu ◽

Yinhui Li ◽

Deng Hu ◽

Xiaoling Chen ◽

Yongmei Liu ◽

...

Keyword(s):

Controlled Release ◽

Aspartic Acid ◽

Vinyl Alcohol ◽

Polymer Network ◽

Interpenetrating Polymer Network ◽

Simulated Gastric Fluid ◽

Poly Vinyl Alcohol ◽

Simulated Intestinal Fluid ◽

Swelling Properties ◽

Drug Controlled Release

Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.

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Macroporous crosslinked hydrophobic/hydrophilic polystyrene/polyamide interpenetrating polymer network: Synthesis, characterization, and adsorption behaviors for quercetin from aqueous solution

Journal of Applied Polymer Science ◽

10.1002/app.32479 ◽

2010 ◽

Vol 118 (6) ◽

pp. 3643-3648 ◽

Cited By ~ 12

Author(s):

Wenwen Liao ◽

Shuqin Gao ◽

Xianglin Xie ◽

Mancai Xu

Keyword(s):

Aqueous Solution ◽

Polymer Network ◽

Interpenetrating Polymer Network ◽

Network Synthesis ◽

Adsorption Behaviors

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Designing of Biodegradable Interpenetrating Polymer Network of Poly(vinyl alcohol-co-acrylic acid)/sodium chloride hydrogel : An Approach to Drug Delivery

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2008.1.2.5 ◽

1970 ◽

Vol 1 (2) ◽

pp. 144-151

Author(s):

Debajyoti Ray ◽

Prafulla Kumar Sahoo ◽

Guru Prasad Mohanta

Keyword(s):

Drug Delivery ◽

Thermal Stability ◽

Sodium Chloride ◽

Polymer Network ◽

Interpenetrating Polymer Network ◽

Poly Vinyl Alcohol ◽

Electron Microscopic ◽

Swelling Properties ◽

Scanning Electron Microscopic Study ◽

Thermal Stability Of

Interpenetrating polymer network (IPN) hydrogel based on polyvinyl alcohol (PVA) networking with polyacrylic acid (PAA), generated insitu, were prepared by without any added crosslinker, using benzoyl peroxide an initiator and sodium chloride (NaCl) as additive. The response of the hydrogels with and without NaCl was observed by studying their swelling behavior, biodegradability and thermal stability. Scanning electron microscopic study revealed that the pores of the prepared IPN were mostly open in presence of NaCl, thus making the hydrogel macroporous. (PVA-co-PAA)/NaCl was found to be more biodegradable than without NaCl. The IPN hydrogel showed comparatively higher swelling at intestinal pH than that of gastric medium and presence of NaCl in the IPN increases the swelling properties in both media. Thermal stability of IPN was affected by copolymerization, due to increasing porosity of the IPN. The prepared nontoxic, hydrophilic IPN hydrogel system holds good for further drug delivery studies in connection to its superswelling and biodegradablity.

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Fabrication and characterization of a novel semi-interpenetrating network hydrogel based on sodium carboxymethyl cellulose and poly(methacrylic acid) for oral insulin delivery

Journal of Biomaterials Applications ◽

10.1177/0885328220912843 ◽

2020 ◽

Vol 35 (1) ◽

pp. 3-14

Author(s):

Shunying Li ◽

Zhiru Chen ◽

Jun Wang ◽

Libiao Yan ◽

Tingting Chen ◽

...

Keyword(s):

Oral Administration ◽

Methacrylic Acid ◽

Carboxymethyl Cellulose ◽

Polymer Network ◽

Insulin Delivery ◽

Interpenetrating Polymer Network ◽

Sodium Carboxymethyl Cellulose ◽

Oral Insulin ◽

Swelling Properties

In this research, pH-sensitive semi-interpenetrating polymer network hydrogels based on sodium carboxymethyl cellulose and poly(methacrylic acid) were synthesized using free radical polymerization and semi-interpenetrating polymer network approach for oral administration of insulin. The chemical structure and thermal stability of the hydrogels were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis measurements. The interior morphology was observed by scanning electron microscopy and the inner structure exhibited a porous honeycomb-like shape. The investigations on the swelling properties of hydrogels revealed their ability to response to pH value change. The in vitro release behavior of insulin was pH dependent and the release of insulin was much lower at pH 1.2 compared to pH 6.8. In vitro cytotoxicity assay indicated that the hydrogels were noncytotoxic to HeLa cells. A sustained reduction in blood glucose level was observed after oral administration of insulin-loaded hydrogel to diabetic rats at 75 IU/kg. These results indicated that the hydrogel would be a promising vehicle for oral insulin delivery systems.

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