Evaluation of In Situ Hardening β‐Tricalcium Phosphate/Poly(lactic‐co‐glycolide) Bone Substitute Used in Edentulous Ridge Preservation for Late Implant Placement: Case Series

Ridge preservation measures, which include the filling of extraction sockets with bone substitutes, have been shown to reduce ridge resorption, while methods that do not require primary soft tissue closure minimize patient morbidity and decrease surgical time and cost. In a case series of 10 patients requiring single extraction,in situhardening beta-tricalcium phosphate (β-TCP) granules coated with poly(lactic-co-glycolic acid) (PLGA) were utilized as a grafting material that does not necessitate primary wound closure. After 4 months, clinical observations revealed excellent soft tissue healing without loss of attached gingiva in all cases. At reentry for implant placement, bone core biopsies were obtained and primary implant stability was measured by final seating torque and resonance frequency analysis. Histological and histomorphometrical analysis revealed pronounced bone regeneration (24.4 ± 7.9% new bone) in parallel to the resorption of the grafting material (12.9 ± 7.7% graft material) while high levels of primary implant stability were recorded. Within the limits of this case series, the results suggest thatβ-TCP coated with polylactide can support new bone formation at postextraction sockets, while the properties of the material improve the handling and produce a stable and porous bone substitute scaffoldin situ, facilitating the application of noninvasive surgical techniques.

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Evaluation of a Poly(Lactic-Co-Glycolic) Acid–Coated β-Tricalcium Phosphate Bone Substitute for Alveolar Ridge Preservation: Case Series

Clinical Advances in Periodontics ◽

10.1902/cap.2017.160092 ◽

2017 ◽

Vol 7 (4) ◽

pp. 190-194 ◽

Cited By ~ 2

Author(s):

Hanae Saito ◽

Harlan J. Shiau ◽

Hari Prasad ◽

Mark A. Reynolds

Keyword(s):

Tricalcium Phosphate ◽

Bone Substitute ◽

Glycolic Acid ◽

Case Series ◽

Ridge Preservation ◽

Alveolar Ridge ◽

Alveolar Ridge Preservation

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A case series of profilometric changes in two implant placement protocols at periodontally compromised non-molar sites

Scientific Reports ◽

10.1038/s41598-021-81402-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kwantae Noh ◽

Daniel S. Thoma ◽

Jung-Chul Park ◽

Dong-Woon Lee ◽

Seung-Yun Shin ◽

...

Keyword(s):

Soft Tissue ◽

Tooth Extraction ◽

Case Series ◽

Tissue Level ◽

Ridge Preservation ◽

Bone Augmentation ◽

Implant Placement ◽

Alveolar Ridge Preservation ◽

Tissue Changes ◽

Facial Area

AbstractInformation regarding profilometric changes at a soft tissue level following implant placement with different protocols is insufficient. Therefore, this study aimed to comparatively investigate the profilometric tissue changes with respect to late implant placement following alveolar ridge preservation (LP/ARP) and early implantation (EP) in periodontally compromised non-molar extraction sites. Sixteen patients were randomly assigned to the following groups: implant placement 4 months post-ARP (group LP/ARP) and tooth extraction and implant placement 4–8 weeks post-extraction (group EP). Dental impressions were obtained immediately after final prosthesis insertion and at 3, 6, and 12 months. At the time of implant placement, bone augmentation was performed in the majority of the patients. Profilometric changes of the tissue contour were minimal between the final prosthesis insertion and 12 months in the mid-facial area (0.04–0.35 mm in group LP/ARP, 0.04–0.19 mm in group EP). The overall tissue volume increased in both groups (1.70 mm3 in group LP/ARP, 0.96 mm3 in group EP). In conclusion, LP/ARP and EP led to similar stability of the peri-implant tissue contour between the final prosthesis insertion and at 12 months. Moreover, the change of peri-implant tissue on the soft tissue level was minimal in both modalities.

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Histological and morphometric aspects of ridge preservation with a moldable, in situ hardening bone graft substitute

Archives of Biological Sciences ◽

10.2298/abs1302429j ◽

2013 ◽

Vol 65 (2) ◽

pp. 429-437 ◽

Cited By ~ 5

Author(s):

M. Jurisic ◽

Milica Manojlovic-Stojanoski ◽

M. Andric ◽

V. Kokovic ◽

Vesna Danilovic ◽

...

Keyword(s):

Porous Scaffold ◽

Calcium Phosphates ◽

Case Series ◽

Bone Graft Substitute ◽

Ridge Preservation ◽

Woven Bone ◽

Barrier Membrane ◽

Morphometric Analyses ◽

Implant Therapy

Biphasic calcium phosphates (BCP) are widely used in alveolar ridge regeneration as a porous scaffold for new bone formation. The aim of this case series was to evaluate the regenerative effect of the combination of BCP and polylactide-co-glycolide (PLGA) which can serve as a barrier membrane during bone regeneration. The study included five patients. Four months into the healing period, bone samples were collected for histological and morphometric analyses. The results of morphometric analysis showed that newly formed bone represented 32.2 ? 6.8% of the tissue, 31.9 ? 8.9% was occupied by residual graft and 35.9 ? 13.5% by soft tissue. Active osteogenesis was seen around the particles of the graft. The particles were occupied mostly by immature woven bone and connective tissue. The quality and quantity of newly formed bone, after the use of BCP/PLGA for ridge preservation, can be adequate for successful implant therapy after tooth extraction.

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Alveolar ridge preservation and early implant placement at maxillary central incisor sites: A prospective case series study

Clinical Oral Implants Research ◽

10.1111/clr.13619 ◽

2020 ◽

Vol 31 (9) ◽

pp. 803-813

Author(s):

Stephen T. Chen ◽

Ivan Darby

Keyword(s):

Case Series ◽

Ridge Preservation ◽

Alveolar Ridge ◽

Central Incisor ◽

Maxillary Central Incisor ◽

Implant Placement ◽

Alveolar Ridge Preservation ◽

Case Series Study ◽

Prospective Case Series ◽

Series Study

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Novel Unidirectional Porous β-Tricalcium Phosphate Used as a Bone Substitute after Excision of Benign Bone Tumors of the Hand: A Case Series

The Journal of Hand Surgery (Asian-Pacific Volume) ◽

10.1142/s2424835518720293 ◽

2018 ◽

Vol 23 (03) ◽

pp. 424-429 ◽

Cited By ~ 7

Author(s):

Akira Ikumi ◽

Toru Funayama ◽

Toshinori Tsukanishi ◽

Hiroshi Noguchi ◽

Masashi Yamazaki

Keyword(s):

Bone Formation ◽

Tricalcium Phosphate ◽

Bone Substitute ◽

Bone Tumors ◽

Animal Studies ◽

Case Series ◽

Clinical Results ◽

Benign Bone Tumors ◽

Tumors Of The Hand ◽

Satisfactory Clinical Result

Unidirectional porous β-tricalcium phosphate (UDPTCP; Affinos®, Kuraray, Tokyo, Japan) has been in clinical use since 2015. Animal studies have confirmed the excellent potential of UDPTCP with regard to bone formation and material absorption. We present the first three clinical cases using UDPTCP as a bone substitute after curettage of benign bone tumors of the hand. All three patients were males, 29-, 30- and 81-years-old, two having a diagnosis of enchondroma and the other, a bone ganglion, with a pathological fracture identified in one case. Over a mean follow-up of 10 months, all patients achieved satisfactory clinical result, with no adverse events of UDPTCP noted. Radiographic evidence of good bone formation and material absorption was observable over the postoperative course. UDPTCP provided satisfactory clinical results, with good biocompatibility and fast resorption characteristics. Therefore, UDPTCP could provide a safe and reliable filling substitute for bone defects following curettage of small bone tumors.

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RESECTION AND REGENERATION- A HOPE FOR THE HOPELESS

10.36106/ijsr/3834076 ◽

2020 ◽

pp. 1-5

Author(s):

Apeksha Annigeri B. ◽

Rajiv Nidasale Puttaswamaiah ◽

Avinash Janaki Lingaraju

Keyword(s):

Alveolar Bone ◽

Treatment Plan ◽

Treatment Options ◽

Case Series ◽

Cost Effective ◽

Ridge Preservation ◽

Tooth Structure ◽

Implant Placement ◽

Long Term Prognosis

Preservation of tooth structure has always been the prime aim of dental practice. Teeth with advanced periodontal disease in multirooted teeth often pose a significant challenge to the clinician, complicating the treatment plan and compromising long term prognosis. The outcome of the treatment is determined by proper case selection and surgical, endodontic and prosthetic parameters. Resective and regenerative osseous procedures are often employed to help preserve the tooth structure, alveolar bone involving the retained root of multirooted teeth and are cost effective over the other treatment options like ridge preservation/augmentation followed by implant placement. This case series describes application of resective and regenerative techniques for molars with extensive combined periodontal-endodontic disease.

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Vertical Bone Gain after Sinus Lift Procedures with Beta-Tricalcium Phosphate and Simultaneous Implant Placement—A Cross-Sectional Study

Medicina ◽

10.3390/medicina56110609 ◽

2020 ◽

Vol 56 (11) ◽

pp. 609

Author(s):

Juan Manuel Aragoneses Lamas ◽

Margarita Gómez Sánchez ◽

Leví Cuadrado González ◽

Ana Suárez García ◽

Javier Aragoneses Sánchez

Keyword(s):

Tricalcium Phosphate ◽

Bone Substitute ◽

Cross Sectional Study ◽

Sinus Lift ◽

Sectional Study ◽

Cross Sectional ◽

Implant Placement ◽

Beta Tricalcium Phosphate ◽

Bone Gain ◽

Implant Length

Objectives: The objective of this cross-sectional study was to evaluate the vertical bone gain achieved after the sinus lift procedure with beta-tricalcium phosphate (β-TCP) used as a bone substitute and simultaneous implant placement. Methods: One hundred and twenty-eight sinus lift procedures (utilizing a synthetic ceramic containing 99.9% tricalcium phosphate as a bone substitute) and simultaneous implant placements were performed on 119 patients. The lateral window approach surgical protocol for maxillary sinus lift was performed on the patients. The implants were evaluated using cone-beam computed tomography (CBCT) at 6 months following placement. The vertical bone gain was considered a primary variable, while implant length, diameter, and location were considered secondary variables. Results: The ANOVA results showed no statistical difference in vertical bone gain with implant parameters like implant length, width, and position. Pearsons correlation revealed a statistically significant positive correlation with vertical bone gain and implant length and diameter. A further multivariate linear regression analysis was performed and it observed statistically significant associations between the variables in the study after adjusting for confounding factors. Conclusions: This study concluded that there was vertical bone gain with the usage of β-TCP in maxillary sinus lift surgical procedure with immediate implant placement and that implant variables like length and diameter had a significant influence on the average bone gain values. The implant position did not have a statistically significant influence but there was considerable variation in the bone gain between first, second premolar, and molar regions.

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