scholarly journals Effect of ethanol extract of boiled breadfruit (Treculia Africana) seed on the oral glucose tolerance, lipid profile, and body weight of normoglycemic albino rats

2018 ◽  
Vol 6 (4) ◽  
pp. 904-911 ◽  
Author(s):  
Kate Eleazu ◽  
Patric Maduabuchi ◽  
Chinedum Eleazu
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Lipid Profile ◽  
Ethanol Extract ◽  
Albino Rats ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Treculia Africana

scholarly journals Antioxidant Property and Oral Glucose Tolerance of Stem Extract of Andrographis paniculata – Nees

2021 ◽  
pp. 21-28
Author(s):  
E. O. Awoyinka ◽  
A. O. Ogundare ◽  
T. T. Adebolu ◽  
Adeloye Adedeji Isaac
Keyword(s):  
Free Radicals ◽  
Glucose Tolerance ◽  
Antioxidant Property ◽  
Andrographis Paniculata ◽  
Albino Rats ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Stem Extract ◽  
Group 5 ◽  
Wistar Albino Rats

This research aims to investigate the antioxidant property and oral glucose tolerance of stem extract of Andrographis paniculata using standard methods. The antioxidant activity of the extracts were assessed using total phenol, total flavonoid, ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)), nitric oxide, GSH (gluthatione), super oxide, DPPH [1,1-di-phenyl-2-picryl hydrazyl] and ascorbic acid.  The oral glucose tolerance of methanol stem extract of A. paniculata was carried out using wistar albino rats. The Wistar albino rats were divided into six groups consisting of five rats each.  Group 1 was given water only, group two to group five were induced with 2g/kg of glucose. After 30 minutes, group 3 and 4 were treated with the doses of 15 mg/kg and 30 mg/kg of the extract while group 5 was treated with glibenclamide respectively. The blood glucose level of each group was monitored for 2hours at 30 minutes interval and compared with the control that was given water only. The result shows that the extracts were able to scavenge free radicals but methanol stem extract of A. paniculata performed better in scavenging free radicals as compared to others. The blood sugar levels of the rats treated with doses of 15 and 30 mg/kg of methanol stem extract of A. paniculata were significantly lower than the group of rats that were fed with only glucose and the group of rats treated with glibenclamide. The glucose-lowering efficiency of the extract was between 60-120 minutes. Findings from this present study revealed that A. paniculata is a potential plant that can scavenge free radicals and also possess hypoglycemic activity.

scholarly journals Intact Leptin Receptor Signalling is not Required for the Sustained Weight Loss and Appetite Suppression Induced by Roux-en-Y Gastric Bypass Surgery

2021 ◽  
Author(s):  
Mohammed K. Hankir ◽  
Laura Rotzinger ◽  
Arno Nordbeck ◽  
Caroline Corteville ◽  
Annett Hoffmann ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Body Weight ◽  
Food Intake ◽  
Glucose Tolerance ◽  
Leptin Receptor ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Sustained Weight Loss ◽  
Obese Rats

Leptin is the archetypal adipokine that promotes a negative whole-body energy balance largely through its action on brain leptin receptors. As such, the sustained weight loss and food intake suppression induced by Roux-en-Y gastric bypass (RYGB) surgery have been attributed to enhancement of endogenous leptin action. We formally revisited this idea in Zucker Fatty fa/fa rats, an established genetic model of leptin receptor deficiency, and carefully compared their body weight, food intake and oral glucose tolerance after RYGB with that of sham-operated fa/fa (obese) and sham-operated fa/+ (lean) rats. We found that RYGB rats sustainably lost body weight, which converged with that of lean rats and was 25.5 % lower than that of obese rats by the end of the 4 week study period. Correspondingly, daily food intake of RYGB rats was similar to that of lean rats from the second postoperative week, while it was always at least 33.9 % lower than that of obese rats. Further, oral glucose tolerance of RYGB rats was normalized at the forth postoperative week. These findings assert that leptin is not an essential mediator of the sustained weight loss and food intake suppression as well as the improved glycemic control induced by RYGB, and instead point to additional circulating and/or neural factors.

scholarly journals Phytochemical Screening, Physicochemical Properties, Acute Toxicity Testing and Screening of Hypoglycaemic Activity of Extracts ofEremurus himalaicusBaker in Normoglycaemic Wistar Strain Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Ahlam Mushtaq ◽  
Seema Akbar ◽  
Mohammad A. Zargar ◽  
Adil F. Wali ◽  
Akhtar H. Malik ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Dose Level ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Phytochemical Screening ◽  
Meoh Extract ◽  
Hypoglycaemic Activity

In the present study EtOAc, MeOH, and aqueous extracts ofEremurus himalaicuswere evaluated for hypoglycaemic effect in normal rats using both oral glucose tolerance test and 14-day oral administration study. Phytochemical and physicochemical screening was also done. In oral glucose tolerance test the aqueous and MeOH extracts ofEremurus himalaicusat a dose level of 500 mg/kg body weight prior to glucose load resulted in a significant fall in blood glucose level within 150 min. of glucose administration. The aqueous extract at a dose level of 250 mg/kg body weight and 500 mg/kg body weight also showed good hypoglycaemic response (P< 0.001); this was followed by MeOH extract at a dose level of 500 mg/kg body weight (P< 0.05), while MeOH extract at dose level of 250 mg/kg body weight and ethyl acetate extract at dose level of 250 mg/kg body weight and 500 mg/kg body weight exhibited insignificant effect. Phytochemical screening of extracts revealed the presence of alkaloids, terpenoids, phenolics, tannins, saponins, cardiac glycosides, and flavonoids. The results indicate that aqueous extract possess significant hypoglycaemic activity in normoglycaemic rats which may be attributed to the above-mentioned chemical constituents.

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