Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in Taiwan

Head & Neck ◽  
2019 ◽  
Vol 41 (6) ◽  
pp. 1557-1564 ◽  
Author(s):  
Hsin‐I Huang ◽  
Chung‐Ho Chen ◽  
Sheng‐Hung Wang ◽  
Li‐Hsuan Wang ◽  
Ying‐Chu Lin
Keyword(s):  
Overall Survival ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Ape1 Asp148glu

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?

2018 ◽  
Vol 28 (9) ◽  
pp. 1650-1656 ◽  
Author(s):  
Munetoshi Akazawa ◽  
Sachiko Onjo
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Clinical Characteristics ◽  
Case Series ◽  
Cystic Teratoma ◽  
The Other ◽  
The Mean

ObjectivesMalignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC.MethodsA systematic literature search of literature published from 2000 to 2017 was conducted in PubMed, Web of Science, and Scopus. We reviewed case series that included all pathological types of malignant transformation.ResultsA total of 155 cases from 15 case series, including our cases, were included. Of the cases, 90 (58%) were SCC and 65 (42%) were non-SCC, including adenocarcinoma, carcinoid tumor, thyroid carcinoma, sarcoma, adenosquamous carcinoma, melanoma, sebaceous carcinoma, oligodendroglioma, signet ring cell carcinoma, and transitional cell carcinoma, in descending order of frequency. The mean ages of patients with SCC and non-SCC were 50.5 and 48.9 years, respectively. The mean tumor sizes were 14.7 cm in SCC and 13.9 cm in non-SCC. Surgical approaches were similar. First-line chemotherapy for epithelial ovarian cancers was the most commonly used regimen in SCC and non-SCC. Overall survival did not differ significantly, showing better prognosis in stage I and poor prognosis in stages II, III, and IV. A difference in overall survival was observed among pathological types of non-SCC.ConclusionsClinical characteristics and outcomes did not differ significantly between SCC and non-SCC. However, chemotherapy regimens differed to some extent, and the possibility of difference in overall survival among pathological types of non-SCC was suggested.

scholarly journals IL‐1β Promotes Malignant Transformation and Tumor Aggressiveness in Oral Cancer

2014 ◽  
Vol 230 (4) ◽  
pp. 875-884 ◽  
Author(s):  
Chia‐Huei Lee ◽  
Jeffrey Shu‐Ming Chang ◽  
Shih‐Han Syu ◽  
Thian‐Sze Wong ◽  
Jimmy Yu‐Wai Chan ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Malignant Transformation ◽  
Tumor Aggressiveness

Loss of Heterozygosity 1p36 and 19q13 Is a Prognostic Factor for Overall Survival in Patients With Diffuse WHO Grade 2 Gliomas Treated Without Chemotherapy

2006 ◽  
Vol 24 (29) ◽  
pp. 4758-4763 ◽  
Author(s):  
Luigi Mariani ◽  
Gianluca Deiana ◽  
Erik Vassella ◽  
Ali-Reza Fathi ◽  
Christine Murtin ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factor ◽  
Malignant Transformation ◽  
Loss Of Heterozygosity ◽  
Progression Free Survival ◽  
Who Grade ◽  
Free Survival ◽  
Extent Of Surgery ◽  
Oligodendroglial Component ◽  
The Impact

Purpose This study was conducted to elucidate the impact of loss of heterozygosity (LOH) for chromosomes 1p36 and 19q13 on the overall survival of patients with diffusely infiltrating WHO grade 2 gliomas treated without chemotherapy. Patients and Methods We assessed the LOH status of tumors from patients harboring WHO grade 2 gliomas diagnosed between 1991 and 2000. Patients were either followed after initial biopsy or treated by surgery and/or radiation therapy (RT). Overall survival, time to malignant transformation, and progression-free survival were last updated as of March 2005. Results Of a total of 79 patients, LOH 1p36 and LOH 19q13 could be assessed in 67 and 66 patients, respectively. The median follow-up after diagnosis was 6 years. Loss of either 1p or 19q, in particular codeletion(s) at both loci, was found to positively impact on both overall survival (log-rank P < .01), progression-free survival, and survival without malignant transformation (P < .05). Tumor volume (P < .0001), neurologic deficits at diagnosis (P < .01), involvement of more than one lobe (P < .01), and absence of an oligodendroglial component (P < .05) were also predictors of shorter overall survival. The extent of surgery was similar in patients with or without LOH 1p and/or 19q; RT was more frequently resorted to for patients without than for patients with LOH 1p/19q (30% v 60%). Conclusion The presence of LOH on either 1p36 or 19q13, and in particular codeletion of both loci is a strong, nontreatment-related, prognostic factor for overall survival in patients with diffusely infiltrating WHO grade 2 gliomas.

scholarly journals An Update on Precancerous Lesions of Oral Cavity

2018 ◽  
Vol 2 (1) ◽  
pp. 70 ◽  
Author(s):  
Deepak Goyal ◽  
Pardeep Goyal ◽  
Harkanwal Preet Singh ◽  
Chanchal Verma
Keyword(s):  
Head And Neck Cancer ◽  
Survival Rate ◽  
High Risk ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Death Rate ◽  
Precancerous Lesions ◽  
Correct Diagnosis ◽  
Premalignant Lesions ◽  
Timely Treatment

Oral cancer is the most common head and neck cancer, found in 270,000 patients annually worldwide. Some cancers develop from precancerous lesions; however, there is no definitive clinico pathological factor or biomarker that reliably enables malignant transformation to be predicted in an individual patient. Early detection and early treatment of oral cancer are important for improving the survival rate of patients; prevention of oral cancer will clearly contribute most to decreasing its death rate. So correct diagnosis and timely treatment of premalignant lesions with high risk of malignant transformation may help to prevent malignant transformation.

Severe postoperative dysphagia as an early predictor for decreased overall survival in patients with oral cancer

2019 ◽  
Vol 47 (9) ◽  
pp. 1363-1369 ◽  
Author(s):  
Christoph Klingelhöffer ◽  
Annegret Obst ◽  
Tobias Ettl ◽  
Johannes Meier ◽  
Steffen Müller ◽  
...  
Keyword(s):  
Overall Survival ◽  
Oral Cancer ◽  
Postoperative Dysphagia ◽  
Early Predictor
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