scholarly journals An Update on Precancerous Lesions of Oral Cavity

2018 ◽  
Vol 2 (1) ◽  
pp. 70 ◽  
Author(s):  
Deepak Goyal ◽  
Pardeep Goyal ◽  
Harkanwal Preet Singh ◽  
Chanchal Verma
Keyword(s):  
Head And Neck Cancer ◽  
Survival Rate ◽  
High Risk ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Death Rate ◽  
Precancerous Lesions ◽  
Correct Diagnosis ◽  
Premalignant Lesions ◽  
Timely Treatment

Oral cancer is the most common head and neck cancer, found in 270,000 patients annually worldwide. Some cancers develop from precancerous lesions; however, there is no definitive clinico pathological factor or biomarker that reliably enables malignant transformation to be predicted in an individual patient. Early detection and early treatment of oral cancer are important for improving the survival rate of patients; prevention of oral cancer will clearly contribute most to decreasing its death rate. So correct diagnosis and timely treatment of premalignant lesions with high risk of malignant transformation may help to prevent malignant transformation.

scholarly journals DNA Methylation Patterns in Saliva of Tobacco users with High-Risk Oral Potentially Malignant Disorders

2021 ◽  
pp. 129-137
Author(s):  
Mimansha Patel ◽  
Madhuri Nitin Gawande ◽  
Minal Shashikant Chaudhary ◽  
Alka Harish Hande
Keyword(s):  
Dna Methylation ◽  
High Risk ◽  
Malignant Transformation ◽  
Promoter Methylation ◽  
Genomic Dna ◽  
Premalignant Lesions ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Methylation Patterns

Background: “Oral Potentially Malignant Disorder (OPMD)” is a well-known symptom that, if untreated, can be carcinogenic. It includes leukoplakia, erythroplakia or erythroleukoplakia. One of the typical premalignant lesions of the oral cavity is “oral leukoplakias (OLs),” which frequently precedes “OSCCs.”OLs with dysplastic characteristics are considered to be at a higher risk of “malignant transformation.” So, early diagnosis of "oral squamous cell carcinomas (OSCCs)" is desperately required to enhance patient prognosis and quality of life (QOL).As a result, we examined the distinctive promoter methylation presence in high-risk OLs. Objectives: To detect, compare & correlate “DNA methylation” patterns in normal individuals, tobacco users without disease and tobacco users with the disease. Methodology: With the participants' full consent, 48 saliva samples were obtained and prepared. DNA isolation, restriction digestion of genomic DNA, extraction of restriction enzyme digested genomic DNA, Polymerase Chain Reaction (PCR), and Agarose Gel Electrophoresis (AGE) were all carried out. Expected results: This study will help us to assess the use of Saliva as an aid to identifying both high and low risk “Oral Potentially Malignant Disorders.” Conclusion: Peculiar promoter methylation of various genes was related to a high possibility of malignant transformation in OLs.

scholarly journals A szájüregi szűrés költséghatékonysága Magyarországon

2016 ◽  
Vol 157 (29) ◽  
pp. 1161-1170
Author(s):  
Zoltán Vokó ◽  
Gergő Túri ◽  
Adriána Zsólyom
Keyword(s):  
Cost Effectiveness ◽  
High Risk ◽  
Oral Cancer ◽  
Time Course ◽  
Precancerous Lesions ◽  
Participation Rate ◽  
Cost Effective ◽  
Health State ◽  
Opportunistic Screening ◽  
Life Years

Introduction: The burden of oral cancer is high in Hungary. Aim: To study the cost-effectiveness of potential oral cancer screening in Hungary. Method: Three strategies were compared: no introduction of screening, organized yearly screening for 40-year-old males in general medical practise, and opportunistic screening of high risk 40-year-old males in primary care. Local estimates of health utilities and costs of each health state and of the screening programmes were identified. The main outcomes were total costs, quality adjusted life years, and incremental cost-effectiveness ratios. Results: Depending on the efficacy of the treatments of precancerous lesions and the participation rate, screening strategies are cost-effective over a 15–20 year time course. The opportunistic screening of high risk people is more cost-effective than the other strategies. Conclusions: Opportunistic screening of high risk people would be cost-effective in Hungary. The uncertainty about the efficacy of the treatments of precancerous lesions requires more research to support evidence based health policy making. Orv. Hetil., 2016, 157(29), 1161–1170.

scholarly journals SIADH: A RARE ENTITY IN HEAD AND NECK CANCER- A CASE REPORT WITH REVIEW OF LITERATURE

2020 ◽  
pp. 1-3
Author(s):  
Rinsha Gireesh ◽  
Kaustubh Bendale ◽  
Subha Lakshmi ◽  
Shiva Bharani
Keyword(s):  
Head And Neck Cancer ◽  
Case Report ◽  
Survival Rate ◽  
Oral Cancer ◽  
Cancer Patient ◽  
Head And Neck ◽  
Neck Cancer ◽  
Rare Entity ◽  
Review Of Literature ◽  
Rare Finding

Hyponatremia secondary to malignancy is a rare finding. Syndrome of inappropriate ADH secretion in head and neck cancer patient can be a serious comorbidity leading to decline in the survival rate. However, most of the time it goes undetected at the outset. And the pathophysiology of this link is not clarified. This article highlights a case of SIADH developed in 40-yr-old man with oral cancer. Also, focusses on the importance of diagnosing it and rendering treatment at the earliest.

scholarly journals C-myc amplification in precancerous lesions of oral cavity and larynx

2003 ◽  
Vol 50 (3) ◽  
pp. 117-119 ◽  
Author(s):  
Tanja Ninkovic ◽  
Nasta Dedovic ◽  
Rade Kosanovic ◽  
Bogomir Dimitrijevic ◽  
Obrad Josipovic ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Precancerous Lesions ◽  
Premalignant Lesions ◽  
Pathological Changes ◽  
Neck Tumors ◽  
The Status ◽  
Probable Role ◽  
Transformation Potential ◽  
Chronic Laryngitis

Although myc genes are an important family of oncogenes involved in human carcinogenesis, data concerning its role in head and neck tumors are quite limited. Moreover, information regarding precancerous lesions is almost inexisting. In order to better understand mechanisms of progression of premalignant lesions into malignant and the possible role of c-myc amplification, the status of this oncogene was analyzed in two types of pathological changes known to possess malignant transformation potential oral leukoplakia and chronic laryngitis. In the first type of lesions a high percentage of c-myc activation (33%) was observed pointing to a probable role of myc in leukoplakia malignant transformation, while in the other type of lesion there were no signs of myc amplification.

Oral Cancer Prevention and the Evolution of Molecular-Targeted Drug Development

2005 ◽  
Vol 23 (2) ◽  
pp. 346-356 ◽  
Author(s):  
Scott M. Lippman ◽  
Jon Sudbø ◽  
Waun Ki Hong
Keyword(s):  
High Risk ◽  
Oral Cancer ◽  
Cancer Risk ◽  
Molecular Mechanisms ◽  
Retinoic Acid Receptor ◽  
Intraepithelial Neoplasia ◽  
Complete Resection ◽  
Premalignant Lesions ◽  
Targeted Prevention ◽  
Molecular Targeted Drug

The multifaceted rationale for molecular-targeted prevention of oral cancer is strong. Oral cancer is a major global threat to public health, causing great morbidity and mortality rates that have not improved in decades. Oral cancer development is a tobacco-related multistep and multifocal process involving field carcinogenesis and intraepithelial clonal spread. Biomarkers of genomic instability, such as aneuploidy and allelic imbalance, can accurately measure the cancer risk of oral premalignant lesions, or intraepithelial neoplasia (IEN). Retinoid–oral IEN studies (eg, of retinoic acid receptor-beta, p53, genetic instability, loss of heterozygosity, and cyclin D1) have advanced the overall understanding of the biology of intraepithelial carcinogenesis and of preventive agent molecular mechanisms and targets—important advances for monitoring preventive interventions and assessing cancer risk and pharmacogenomics. Clinical management of oral IEN varies from watchful waiting to complete resection, although complete resection does not prevent oral cancer in high-risk patients. New approaches, such as interventions with molecular-targeted agents and agent combinations in molecularly defined high-risk oral IEN patients, are urgently needed to reduce the devastating worldwide consequences of oral cancer.

scholarly journals Kinesin Family Member C1 (KIFC1/HSET): A Potential Actionable Biomarker of Early Stage Breast Tumorigenesis and Progression of High-Risk Lesions

2021 ◽  
Vol 11 (12) ◽  
pp. 1361
Author(s):  
Nikita Wright ◽  
Zhihong Gong ◽  
Rick Kittles ◽  
Rama Natarajan ◽  
Tijana Jovanovic-Talisman ◽  
...  
Keyword(s):  
High Risk ◽  
Family Member ◽  
Malignant Transformation ◽  
Early Stage ◽  
High Risk Patient ◽  
Premalignant Lesions ◽  
Breast Cancers ◽  
Neoplastic Progression ◽  
Breast Tumorigenesis ◽  
Kinesin Family

The enigma of why some premalignant or pre-invasive breast lesions transform and progress while others do not remains poorly understood. Currently, no radiologic or molecular biomarkers exist in the clinic that can successfully risk-stratify high-risk lesions for malignant transformation or tumor progression as well as serve as a minimally cytotoxic actionable target for at-risk subpopulations. Breast carcinogenesis involves a series of key molecular deregulatory events that prompt normal cells to bypass tumor-suppressive senescence barriers. Kinesin family member C1 (KIFC1/HSET), which confers survival of cancer cells burdened with extra centrosomes, has been observed in premalignant and pre-invasive lesions, and its expression has been shown to correlate with increasing neoplastic progression. Additionally, KIFC1 has been associated with aggressive breast tumor molecular subtypes, such as basal-like and triple-negative breast cancers. However, the role of KIFC1 in malignant transformation and its potential as a predictive biomarker of neoplastic progression remain elusive. Herein, we review compelling evidence suggesting the involvement of KIFC1 in enabling pre-neoplastic cells to bypass senescence barriers necessary to become immortalized and malignant. We also discuss evidence inferring that KIFC1 levels may be higher in premalignant lesions with a greater inclination to transform and acquire aggressive tumor intrinsic subtypes. Collectively, this evidence provides a strong impetus for further investigation into KIFC1 as a potential risk-stratifying biomarker and minimally cytotoxic actionable target for high-risk patient subpopulations.

scholarly journals Prevalence of Human Papillomavirus in 45 Greek Patients with Oral Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Maria Kouvousi ◽  
Dimitra Xesfyngi ◽  
Elpida Tsimplaki ◽  
Elena Argyri ◽  
Georgia Ioannidou ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Oral Cancer ◽  
Mrna Expression ◽  
Squamous Cell Carcinomas ◽  
Hpv Dna ◽  
Dna And Rna ◽  
Hpv Genotypes ◽  
High Risk Hpv

The relation between HPV and head and neck cancer has recently and extensively been investigated. The purpose of this study was to indentify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33 and 45) in oral squamous cell carcinomas (OSCCs) from 45 Greek patients. The overall prevalence of HPV DNA positive OSCCs was 11.1% (5/45), while high-risk HPV DNA was found in 6.7% (3/45) of OSCCs. E6/E7 mRNA expression was detected in 8.9% (4/45) of the oral cavity samples. Our data indicated that HPV 16 was the commonest genotype identified in HPV-positive OSCCs by both DNA and RNA tests. This study confirms the prevalence of HPV infections among patients with OSCCs. Future analysis and followup of more OSCCs will enable us to correlate HPV detection and clinical outcome.

Neuroblastoma: An Updated Review on Biology and Treatment

2020 ◽  
Vol 20 (13) ◽  
pp. 1014-1022 ◽  
Author(s):  
Suresh Mallepalli ◽  
Manoj Kumar Gupta ◽  
Ramakrishna Vadde
Keyword(s):  
Survival Rate ◽  
High Risk ◽  
Molecular Mechanisms ◽  
Definitive Treatment ◽  
Therapeutic Drug ◽  
Mycn Amplification ◽  
Dependent Manner ◽  
High Risk Patients ◽  
Treatment And Prevention ◽  
Risk Patients

Background: Neuroblastoma (NB) is the second leading extracranial solid tumors of early childhood and clinically characterized by the presence of round, small, monomorphic cells with excess nuclear pigmentation (hyperchromasia).Owing to a lack of definitive treatment against NB and less survival rate in high-risk patients, there is an urgent requirement to understand molecular mechanisms associated with NB in a better way, which in turn can be utilized for developing drugs towards the treatment of NB in human. Objectives: In this review, an approach was adopted to understand major risk factors, pathophysiology, the molecular mechanism associated with NB, and various therapeutic agents that can serve as drugs towards the treatment of NB in humans. Conclusions: Numerous genetic (e.g., MYCN amplification), perinatal, and gestational factors are responsible for developing NB. However, no definite environmental or parental exposures responsible for causing NB have been confirmed to date. Though intensive multimodal treatment approaches, namely, chemotherapy, surgery &radiation, may help in improving the survival rate in children, these approaches have several side effects and do not work efficiently in high-risk patients. However, recent studies suggested that numerous phytochemicals, namely, vincristine, and matrine have a minimal side effect in the human body and may serve as a therapeutic drug during the treatment of NB. Most of these phytochemicals work in a dose-dependent manner and hence must be prescribed very cautiously. The information discussed in the present review will be useful in the drug discovery process as well as treatment and prevention on NB in humans.

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