Glycolipids of germ cell tumors: Extended globo-series glycolipids are a hallmark of human embryonal carcinoma cells

1994 ◽  
Vol 58 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Jonathan Wenk ◽  
Peter W. Andrews ◽  
Jochen Casper ◽  
Jun-Ichi Hata ◽  
Martin F. Pera ◽  
...  
Development ◽  
2018 ◽  
Vol 145 (6) ◽  
pp. dev156612 ◽  
Author(s):  
Emily P. Dawson ◽  
Denise G. Lanza ◽  
Nicholas J. Webster ◽  
Susan M. Benton ◽  
Isao Suetake ◽  
...  

Development ◽  
2021 ◽  
Vol 148 (9) ◽  
Author(s):  
Nicholas J. Webster ◽  
Rebecca L. Maywald ◽  
Susan M. Benton ◽  
Emily P. Dawson ◽  
Oscar D. Murillo ◽  
...  

ABSTRACT In response to signals from the embryonic testis, the germ cell intrinsic factor NANOS2 coordinates a transcriptional program necessary for the differentiation of pluripotent-like primordial germ cells toward a unipotent spermatogonial stem cell fate. Emerging evidence indicates that genetic risk factors contribute to testicular germ cell tumor initiation by disrupting sex-specific differentiation. Here, using the 129.MOLF-Chr19 mouse model of testicular teratomas and a NANOS2 reporter allele, we report that the developmental phenotypes required for tumorigenesis, including failure to enter mitotic arrest, retention of pluripotency and delayed sex-specific differentiation, were exclusive to a subpopulation of germ cells failing to express NANOS2. Single-cell RNA sequencing revealed that embryonic day 15.5 NANOS2-deficient germ cells and embryonal carcinoma cells developed a transcriptional profile enriched for MYC signaling, NODAL signaling and primed pluripotency. Moreover, lineage-tracing experiments demonstrated that embryonal carcinoma cells arose exclusively from germ cells failing to express NANOS2. Our results indicate that NANOS2 is the nexus through which several genetic risk factors influence tumor susceptibility. We propose that, in the absence of sex specification, signals native to the developing testis drive germ cell transformation.


1985 ◽  
Vol 122 (3) ◽  
pp. 379-386 ◽  
Author(s):  
John S. Zuzack ◽  
Richard J. Tasca ◽  
Stephen M. DiZio

2014 ◽  
Vol 74 (12) ◽  
pp. 1243-1254 ◽  
Author(s):  
Rocío Jiménez Alfonso ◽  
Irantzu Gorroño-Etxebarria ◽  
Miriam Rabano ◽  
Maria dM. Vivanco ◽  
Robert Kypta

2011 ◽  
Vol 10 (2) ◽  
pp. 255-268 ◽  
Author(s):  
Rakshamani Tripathi ◽  
Tanmoy Samadder ◽  
Sarika Gupta ◽  
Avadhesha Surolia ◽  
Chandrima Shaha

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