scholarly journals Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency

Development ◽  
2018 ◽  
Vol 145 (6) ◽  
pp. dev156612 ◽  
Author(s):  
Emily P. Dawson ◽  
Denise G. Lanza ◽  
Nicholas J. Webster ◽  
Susan M. Benton ◽  
Isao Suetake ◽  
...  
Keyword(s):  
Germ Cell ◽  
Embryonal Carcinoma ◽  
Carcinoma Cells ◽  
Male Germ Cell ◽  
Embryonal Carcinoma Cells

Glycolipids of germ cell tumors: Extended globo-series glycolipids are a hallmark of human embryonal carcinoma cells

1994 ◽  
Vol 58 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Jonathan Wenk ◽  
Peter W. Andrews ◽  
Jochen Casper ◽  
Jun-Ichi Hata ◽  
Martin F. Pera ◽  
...  
Keyword(s):  
Germ Cell ◽  
Embryonal Carcinoma ◽  
Germ Cell Tumors ◽  
Carcinoma Cells ◽  
Embryonal Carcinoma Cells ◽  
Globo Series

scholarly journals Testicular germ cell tumors arise in the absence of sex-specific differentiation

Development ◽  
2021 ◽  
Vol 148 (9) ◽  
Author(s):  
Nicholas J. Webster ◽  
Rebecca L. Maywald ◽  
Susan M. Benton ◽  
Emily P. Dawson ◽  
Oscar D. Murillo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Germ Cell ◽  
Germ Cells ◽  
Genetic Risk ◽  
Embryonal Carcinoma ◽  
Genetic Risk Factors ◽  
Carcinoma Cells ◽  
Embryonal Carcinoma Cells ◽  
Testicular Germ Cell ◽  
Specific Differentiation

ABSTRACT In response to signals from the embryonic testis, the germ cell intrinsic factor NANOS2 coordinates a transcriptional program necessary for the differentiation of pluripotent-like primordial germ cells toward a unipotent spermatogonial stem cell fate. Emerging evidence indicates that genetic risk factors contribute to testicular germ cell tumor initiation by disrupting sex-specific differentiation. Here, using the 129.MOLF-Chr19 mouse model of testicular teratomas and a NANOS2 reporter allele, we report that the developmental phenotypes required for tumorigenesis, including failure to enter mitotic arrest, retention of pluripotency and delayed sex-specific differentiation, were exclusive to a subpopulation of germ cells failing to express NANOS2. Single-cell RNA sequencing revealed that embryonic day 15.5 NANOS2-deficient germ cells and embryonal carcinoma cells developed a transcriptional profile enriched for MYC signaling, NODAL signaling and primed pluripotency. Moreover, lineage-tracing experiments demonstrated that embryonal carcinoma cells arose exclusively from germ cells failing to express NANOS2. Our results indicate that NANOS2 is the nexus through which several genetic risk factors influence tumor susceptibility. We propose that, in the absence of sex specification, signals native to the developing testis drive germ cell transformation.

Expression of fibroblast growth factor receptors by embryonal carcinoma cells and early mouse embryos

1992 ◽  
Vol 28 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Wendy J. Campbell ◽  
Keith A. Miller ◽  
Todd M. Anderson ◽  
James D. Shull ◽  
Angie Rizzino
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Embryonal Carcinoma ◽  
Growth Factor Receptors ◽  
Mouse Embryos ◽  
Carcinoma Cells ◽  
Fibroblast Growth ◽  
Embryonal Carcinoma Cells ◽  
Fibroblast Growth Factor Receptors ◽  
Early Mouse

Neutral amino acid transport in embryonal carcinoma cells

1985 ◽  
Vol 122 (3) ◽  
pp. 379-386 ◽  
Author(s):  
John S. Zuzack ◽  
Richard J. Tasca ◽  
Stephen M. DiZio
Keyword(s):  
Amino Acid ◽  
Amino Acid Transport ◽  
Embryonal Carcinoma ◽  
Carcinoma Cells ◽  
Neutral Amino Acid ◽  
Embryonal Carcinoma Cells ◽  
Acid Transport

Dickkopf-3 alters the morphological response to retinoic acid during neuronal differentiation of human embryonal carcinoma cells

2014 ◽  
Vol 74 (12) ◽  
pp. 1243-1254 ◽  
Author(s):  
Rocío Jiménez Alfonso ◽  
Irantzu Gorroño-Etxebarria ◽  
Miriam Rabano ◽  
Maria dM. Vivanco ◽  
Robert Kypta
Keyword(s):  
Retinoic Acid ◽  
Neuronal Differentiation ◽  
Embryonal Carcinoma ◽  
Carcinoma Cells ◽  
Embryonal Carcinoma Cells ◽  
Morphological Response

scholarly journals Anticancer Activity of a Combination of Cisplatin and Fisetin in Embryonal Carcinoma Cells and Xenograft Tumors

2011 ◽  
Vol 10 (2) ◽  
pp. 255-268 ◽  
Author(s):  
Rakshamani Tripathi ◽  
Tanmoy Samadder ◽  
Sarika Gupta ◽  
Avadhesha Surolia ◽  
Chandrima Shaha
Keyword(s):  
Anticancer Activity ◽  
Embryonal Carcinoma ◽  
Carcinoma Cells ◽  
Embryonal Carcinoma Cells
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