Meta-analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss

2017 ◽  
Vol 138 (3) ◽  
pp. 242-249 ◽  
Author(s):  
Heng Zhang ◽  
Zhaohui Huang ◽  
Limin Xiao ◽  
Xinye Jiang ◽  
Daozhen Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnancy Loss ◽  
Meta Analysis ◽  
Maternal Vitamin ◽  
Spontaneous Pregnancy

scholarly journals The effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss in the first trimester

2021 ◽  
Vol 10 (6) ◽  
pp. 2215
Author(s):  
Sharmin Ferdous ◽  
Farhat Hussain ◽  
Samira Hayee ◽  
Nahreen Akhtar ◽  
Suraiya Khanam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnancy Loss ◽  
Serum Vitamin ◽  
First Trimester ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Maternal Vitamin ◽  
Serum Vitamin D ◽  
Spontaneous Pregnancy

Background: Pregnancy loss in the first trimester is one of the most disappointing matters for a mother. But spontaneous pregnancy loss in the first trimester is the most common negative outcome of pregnancy. It's estimated that about 10% of known pregnancies are lost in the first trimester whereas fewer than 4% of pregnancies miscarry in the second trimester. Aim of current study was to assess the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss in the first trimester.Methods: It was a case-control study conducted in the department of obstetrics and gynecology, Sir Salimullah medical college Mitford hospital, Dhaka, Bangladesh during the period of September 2018 to August 2019. A total of 100 patients were included in this study. Statistical analyses of the results were obtained by using window-based computer software devised with SPSS version 22.0.Results: In analyzing the association of serum vitamin D status with first-trimester pregnancy state it was observed that more than half (52.0%) patients had severe deficiency (<10 ng/ml) in the case group and 14 (28.0%) patients in the control group. In total 24 (48.0%) patients had deficiency (10-20 ng/ml) in case and 35 (70.0%) in control group. Only 1 (2.0%) patient had insufficiency (21-29 ng/ml) in control group. The difference was statistically significant (p<0.05) between the two groups.Conclusions: Maternal serum vitamin D deficiency was significantly associated with early spontaneous pregnancy loss in the first trimester.

scholarly journals Correlation between Serum Vitamin D Deficiency and Early Spontaneous Pregnancy Loss

2021 ◽  
Vol 4 (4) ◽  
pp. 131-135
Author(s):  
  Dr. Mst. Sharmin Ferdous ◽  
Farhat Hussain ◽  
Dr. Samira Hayee ◽  
Nahreen Akhtar ◽  
Dr. Suraiya Khanam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pregnancy Loss ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Spontaneous Pregnancy

scholarly journals Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis

2018 ◽  
Vol 45 (1) ◽  
pp. 291-300 ◽  
Author(s):  
Lingmin Hu ◽  
Yue Zhang ◽  
Xing Wang ◽  
Lianghui You ◽  
Pengfei Xu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gestational Diabetes ◽  
Observational Studies ◽  
Meta Analysis ◽  
Vitamin D Insufficiency ◽  
Significant Heterogeneity ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Increased Risk ◽  
Maternal Vitamin D Status

Background/Aims: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. Methods: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models. Results: The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95%CI = 1.20-1.60) with moderate heterogeneity (I2 = 50.2%; P = 0.001). Moreover, the 25(OH)D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I2 = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations. Conclusion: This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association.

scholarly journals Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e016404 ◽  
Author(s):  
Yao Chen ◽  
Beibei Zhu ◽  
Xiaoyan Wu ◽  
Si Li ◽  
Fangbiao Tao
Keyword(s):  
Vitamin D ◽  
Cohort Studies ◽  
Vitamin D Deficiency ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Maternal Vitamin ◽  
Prospective Cohort Studies

ObjectiveTo determine whether maternal vitamin D deficiency during pregnancy is associated with small for gestational age (SGA).MethodsA comprehensive literature search of PubMed, the Cochrane Library, Embase, and the Elsevier ScienceDirect library was conducted to identify relevant articles reporting prospective cohort studies in English, with the last report included published in February 2017. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to evaluate the correlation in a random effects model.ResultsA total of 13 cohort studies were included in this meta-analysis with a sample of 28 285 individuals from seven countries. The pooled overall OR for babies born SGA was 1.588 (95%CI 1.138 to 2.216; p<0.01) for women with vitamin D deficiency. The prevalence of vitamin D deficiency during pregnancy varied from 13.2% to 77.3%. Subgroup analyses identified no significant differences in the association between vitamin D deficiency and SGA based on study quality, gestational week during which blood sampling was performed, cut-off vitamin D levels, sample size, adjustment for critical confounders and method for measuring vitamin D.ConclusionThis meta-analysis suggests that vitamin D deficiency is associated with an increased risk of SGA.

Association between maternal vitamin D levels and risk of adverse pregnancy outcomes: a systematic review and dose–response meta-analysis

2021 ◽  
Author(s):  
Rui Zhao ◽  
Leilei Zhou ◽  
Shanshan Wang ◽  
Guoping Xiong ◽  
Liping Hao
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Dose Response ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Adverse Pregnancy Outcomes ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
Adverse Pregnancy

Epidemiological studies have investigated the associations between vitamin D and the risk of adverse pregnancy outcomes; however, the results are conflicting and dose–response relationships remain to be confirmed.

scholarly journals Maternal Vitamin D Status and Risk of Pre-Eclampsia: A Systematic Review and Meta-Analysis

2013 ◽  
Vol 98 (8) ◽  
pp. 3165-3173 ◽  
Author(s):  
Marjan Tabesh ◽  
Amin Salehi-Abargouei ◽  
Maryam Tabesh ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Meta Analysis ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Maternal Vitamin D Status
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