Maternal Vitamin D Supplementation Among Lactating Mothers in the Prevention of Vitamin D Deficiency Among Breastfed Term Infants: A Meta Analysis

2018 ◽  
Author(s):  
Angelica Mae A. Hilario ◽  
◽  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Term Infants ◽  
Maternal Vitamin ◽  
Lactating Mothers

scholarly journals Vitamin D in Breastfed Infants: Systematic Review of Alternatives to Daily Supplementation

2019 ◽  
Author(s):  
Karen M O'Callaghan ◽  
Mahgol Taghivand ◽  
Anna Zuchniak ◽  
Akpevwe Onoyovwi ◽  
Jill Korsiak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Vitamin D Supplementation ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Term Infants

ABSTRACT Daily oral vitamin D supplementation (400 IU) is recommended for breastfeeding infants (≤1 y). Recent studies have examined alternative approaches to preventing vitamin D deficiency in this population. This systematic review and meta-analysis aimed to estimate the effects of maternal postpartum (M-PP) or infant intermittent (I-INT) vitamin D supplementation on infant 25-hydroxyvitamin D [25(OH)D] concentrations in comparison to routine direct infant daily (I-D) oral supplementation (400 IU). MEDLINE, MEDLINE In-Process, Embase, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched up to December 2018. Inclusion criteria consisted of published, peer-reviewed, vitamin D intervention trials involving lactating women and/or exclusively or partially breastfed term infants. Two reviewers independently extracted study characteristics (e.g., sample size, intervention dose, and duration and mode of administration) and related biochemical and clinical outcomes. Of 28 included trials, 5 randomized controlled trials were incorporated in meta-analyses examining infant 25(OH)D. Overall, M-PP supplementation resulted in modestly lower infant 25(OH)D compared with I-D supplementation (weighted mean difference = −8.1 nmol/L; 95% CI: −15.4, −0.9; I2 = 45%; P = 0.14; 3 trials), but the 2 most recent trials found M-PP to achieve similar infant 25(OH)D as I-D. Comparison of I-INT with I-D was confined to 2 trials with contradictory findings, and it was considered inappropriate for pooled analysis. Meta-analysis was therefore limited by a small number of eligible trials with variable quality of analytically derived 25(OH)D data and inconsistent reporting of safety outcomes, including effects on calcium homeostasis. Considering all 28 included trials, this systematic review highlights M-PP and I-INT regimens as plausible substitutes for routine daily infant vitamin D supplementation, but evidence remains too weak to support a policy update. Dose-ranging, adequately powered trials are required to establish the efficacy, safety, and feasibility of alternative strategies to prevent vitamin D deficiency in breastfeeding infants. This review was registered with PROSPERO as CRD42017069905.

scholarly journals Is there a benefit of vitamin D supplementation in deficient children and adolescents suffering from obesity? A meta-analysis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M F Nassar ◽  
E K Emam ◽  
M F Allam
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Obese Children ◽  
Intramuscular Dose ◽  
Vitamin D Levels ◽  
Pubmed Search ◽  
Lower Vitamin

Abstract Background and objectives Both childhood obesity and vitamin D deficiency are common in the Middle East. This systematic review/meta-analysis aims to highlight the effect of vitamin D supplementation in deficient children suffering from obesity. Methods Published clinical studies on vitamin D supplementation in obese children and adolescents with vitamin D deficiency were identified through a comprehensive MEDLINE/PubMed search (from July 1966 to November 2017). Outcomes intended after vitamin D supplementation were improvements in vitamin D status, BMI alterations and appetite changes. The inclusion criteria were children aged 2 to 18 years of both sexes in clinical trials that specified the oral and/or intramuscular dose of vitamin D supplementation. Results Ten studies were retrieved, but only six were relevant. First, supplemented obese children and adolescents were compared to non-obese controls; thereafter, supplemented obese children and adolescents were compared to matching obese peers given placebo. Pooled risks from the two studies that evaluated the number of obese and non-obese children and adolescents who improved upon vitamin D supplementation revealed that obesity poses a risk for not benefiting from the vitamin D supplementation regardless of the dose and the duration of supplementation. Pooled results from the six retrieved studies that compared supplemented obese children and adolescents to matching non-obese or obese peers given placebo revealed significantly lower vitamin D levels in obese participants than in non-obese peers. Conclusion Vitamin D levels are significantly lower in obese children and adolescents with obesity, posing a risk for not benefiting from vitamin D supplementation regardless of the dose and duration of supplementation. Our results suggest that only with simultaneous weight adjustment strategies, vitamin D sufficiency would be achieved more effectively. Vitamin D supplementation in deficient children suffering from obesity.

scholarly journals Effects of vitamin D supplementation on 25(OH)D levels and blood pressure in the elderly: a systematic review and meta-analysis

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 633
Author(s):  
Farapti Farapti ◽  
Chusnul Fadilla ◽  
Niwanda Yogiswara ◽  
Merryana Adriani
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Control Groups ◽  
Elderly Age ◽  
Hydroxyvitamin D ◽  
And Control

Background: Hypertension and vitamin D deficiency are prevalent among the elderly. This study evaluated the effects of vitamin D supplementation on changes in serum 25-hydroxyvitamin D (25(OH)D) levels and blood pressure (BP) in the elderly (age > 60 years). Methods: Randomized controlled trials from electronic databases on the elderly taking oral vitamin D, until the end of March 2019, were selected. Two reviewers independently screened the literature on the basis of specific inclusion criteria. The primary outcomes were serum 25(OH)D level, systolic BP (SBP), and diastolic BP (DBP) changes. Results: Our analysis revealed significant differences in serum 25(OH)D level changes between the vitamin D and control groups (mean difference [MD] = 13.84; 95% confidence interval [CI] = 10.21–17.47; P < 0.000). There were no significant differences in SBP and DBP changes between the vitamin D and control groups. Subgroup analysis revealed significant differences in SBP changes between the hypertensive and vitamin D-deficient subgroups (MD = –4.01; 95% CI = –7.45 to –0.57; P = 0.02 and MD = –1.91; 95% CI = –3.48 to –0.34; P = 0.02, respectively), and DBP changes only in the hypertensive subgroup (MD = –2.22; 95% CI = –4.1 to –0.34; P = 0.02). Conclusions: Vitamin D supplementation significantly increases 25(OH)D levels and seems beneficial in lowering BP, specifically in the elderly with elevated BP and vitamin D deficiency.

scholarly journals Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Shan Guo ◽  
Reshef Tal ◽  
Haoyu Jiang ◽  
Tao Yuan ◽  
Ying Liu
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Randomized Controlled Trials ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Serum Triglyceride ◽  
Vitamin D Supplementation ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Randomized Controlled

Objective. Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS. Methods. Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. The effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo. The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42020157444. Results. Thirteen randomized controlled trials with 824 patients in total were included. Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo. Vitamin D supplementation group also showed a significantly elevated level of QUICKI. No significant impact was seen on serum triglyceride, total-C, LDL-C, HDL-C, total testosterone, DHEAS, SHBG, or hs-CRP. Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin D < 20 ng/ml). Conclusion. The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.

scholarly journals Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e016404 ◽  
Author(s):  
Yao Chen ◽  
Beibei Zhu ◽  
Xiaoyan Wu ◽  
Si Li ◽  
Fangbiao Tao
Keyword(s):  
Vitamin D ◽  
Cohort Studies ◽  
Vitamin D Deficiency ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Maternal Vitamin ◽  
Prospective Cohort Studies

ObjectiveTo determine whether maternal vitamin D deficiency during pregnancy is associated with small for gestational age (SGA).MethodsA comprehensive literature search of PubMed, the Cochrane Library, Embase, and the Elsevier ScienceDirect library was conducted to identify relevant articles reporting prospective cohort studies in English, with the last report included published in February 2017. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to evaluate the correlation in a random effects model.ResultsA total of 13 cohort studies were included in this meta-analysis with a sample of 28 285 individuals from seven countries. The pooled overall OR for babies born SGA was 1.588 (95%CI 1.138 to 2.216; p<0.01) for women with vitamin D deficiency. The prevalence of vitamin D deficiency during pregnancy varied from 13.2% to 77.3%. Subgroup analyses identified no significant differences in the association between vitamin D deficiency and SGA based on study quality, gestational week during which blood sampling was performed, cut-off vitamin D levels, sample size, adjustment for critical confounders and method for measuring vitamin D.ConclusionThis meta-analysis suggests that vitamin D deficiency is associated with an increased risk of SGA.

scholarly journals Effect of Maternal Vitamin D Supplementation on Iron Status During Pregnancy

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1054-1054
Author(s):  
Karen O'Callaghan ◽  
Ulaina Tariq ◽  
Alison Gernand ◽  
Maria Tinajero ◽  
Akpevwe Onoyovwi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Ferritin ◽  
Iron Status ◽  
Geometric Mean ◽  
Vitamin D Supplementation ◽  
Late Gestation ◽  
Double Blind ◽  
Maternal Vitamin ◽  
Few Data

Abstract Objectives Vitamin D may have an adjunctive role in the prevention and treatment of iron deficiency (ID) through its proposed role in the regulation of erythropoiesis and circulating hepcidin concentrations. Observational studies have shown associations between low vitamin D and iron status; however, there are few data from intervention trials. In participants of the Maternal Vitamin D for Infant Growth Trial (MDIG; NCT01924013), among whom the baseline prevalence of vitamin D deficiency was 64%, we examined the effect of prenatal vitamin D supplementation on iron status during pregnancy by testing the effect of vitamin D supplementation on serum ferritin concentrations. Methods In this double-blind, dose-response, randomized trial in Dhaka, Bangladesh, women were recruited at 17–24 weeks’ gestation and randomly assigned to receive a prenatal vitamin D3 dose of 4200, 16,800, 28,000 IU/week or placebo. Serum ferritin was quantified using an electro-chemiluminescence immunoassay. Plasma C-reactive protein (CRP) was analysed by enzyme-linked immunoassay. Linear regression was used to test the hypothesized effect of vitamin D supplementation on serum ferritin (n = 1011 of 1300 enrolled). In a sensitivity analysis, we adjusted for concurrent CRP to correct for inflammation (n = 920). Regression correction was used to generate an inflammation-corrected estimate of the prevalence of ID (n = 920). Results Prevalence of ID (serum ferritin &lt;15 µg/L) was high overall (27% corrected for inflammation; 12% uncorrected). Geometric mean (95% confidence interval) serum ferritin concentrations were lower in each of the vitamin D supplementation groups [43.1 (38.1, 48.7), 44.8 (40.4, 49.7) and 45.1 (41.5, 49.1) µg/L in the 4200, 16,800 and 28,000 IU/week groups, respectively] compared to the placebo group [50.3 µg/L (45.0, 56.2)], although none of the pairwise differences between each vitamin D group and placebo were statistically significant at the P &lt; 0.05 threshold. Adjusting for CRP did not change the inferences. Conclusions In a population with concurrently high prevalence rates of iron and vitamin D deficiency, prenatal vitamin D supplementation did not lead to improvements in iron status by late gestation. The possibility of a negative effect of vitamin D supplementation on iron status should be further explored. Funding Sources The Bill and Melinda Gates Foundation.

scholarly journals Vitamin D deficiency or supplementation and the risk of human herpesvirus infections or reactivation: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Liang-Yu Lin ◽  
Ketaki Bhate ◽  
Harriet Forbes ◽  
Liam Smeeth ◽  
Charlotte Warren-Gash ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Herpes Zoster ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Human Herpesvirus ◽  
Vitamin D Supplementation ◽  
Case Control Studies ◽  
Multiple Sclerosis Patients ◽  
Cmv Disease

Abstract Background Vitamin D may protect against respiratory virus infections, but any association with herpesviruses is unclear. Methods We undertook a systematic review of vitamin D deficiency or supplementation and the risk of eight human herpesviruses. Six databases and four gray literature databases were searched for relevant cohort, case-control studies, and clinical trials. Results Ten studies were included, all conducted among immunosuppressed patients. There was no evidence that vitamin D deficiency is associated with CMV disease (pooled risk ratio: 1.06, 95% confidence interval: 0.66,1.7), herpes zoster after transplantation (one study), or HHV-8 among HIV patients (one study). Vitamin D supplementation may decrease herpes zoster among hemodialysis patients (one study) or CMV disease after renal transplantation (one study), but supplementation was not associated with reduced EBV viral load among multiple sclerosis patients (one study). Conclusion Any association between vitamin D and herpesviruses remains inconclusive. Further studies in the general population are needed.

scholarly journals Maternal Vitamin D Deficiency and Fetal Growth

2015 ◽  
Vol 9 (3) ◽  
pp. 223-229
Author(s):  
Christos Ioannou
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Vitamin D Deficiency ◽  
Fetal Growth ◽  
Vitamin D Supplementation ◽  
Skeletal Growth ◽  
Vitamin D Status ◽  
Femur Length ◽  
Maternal Vitamin ◽  
Randomized Controlled

ABSTRACT There is increasing incidence of vitamin D deficiency in pregnancy in developed countries. Dark skinned women who have migrated and live in higher latitudes are at greatest risk. Vitamin D supplementation is now recommended in several countries, yet its impact on fetal growth remains unclear. Observational studies suggest a possible correlation between maternal serum vitaminD and birth weight. However, differences in birth weight can be confounded by soft-tissue growth and placental function. The effect on vitamin D on bone mineral indices using dual energy X-ray absorptiometry is difficult to ascertain in the neonatal period and therefore remains unclear. Prenatal ultrasound is a safe and practical modality for assessing skeletal growth, yet very few studies have investigated fetal growth in the context of vitamin D status: one study has demonstrated no correlation with femur length, whereas two studies have shown positive correlations with femur length and femur volume respectively. The effect of vitamin D supplementation on birth weight has been investigated in seven interventional studies. However, there is considerable methodological heterogeneity and high risk of bias among some of them. Meta-analysis of well conducted randomized controlled trials (RCTs) has not demonstrated a significant effect on birth weight. The effect of vitamin D supplementation on ultrasound markers of fetal growth has not been reported to date. In summary, there is weak evidence that maternal vitamin D status may have a positive association with measures of fetal skeletal growth. However, if such an association exists, it is not clear whether it is causal or spurious. Randomized controlled trials of vitamin D supplementation are needed, where fetal ultrasound and neonatal bone mineral indices will be reported as primary outcome measures. How to cite this article Ioannou C. Maternal Vitamin D Deficiency and Fetal Growth. Donald School J Ultrasound Obstet Gynecol 2015;9(3):223-229.

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