Abstract— This research is aimed to produce a prezi multimedia based on Problem Based Learning (PBL) in Basic Law of Chemistry material and to determine the level ov validaty and practicality based on media’s function. This research is Researc and Development (R&D) which applies 4-D madel: define, design, develop, and disseminate. The research is done until development stage. Determining the level of validity and practicality are done by Chemistry lecturer, Chemistry teacher,and students of class XI IPA SMAN 1 Bukittinggi. The research instrument is questionnaire which consists of validity questionnaire and practicality questionnaire. The technic of data collection is done by distributing questionnaire. The data is analyzed by using moment kappa. From the data analysis,it is found that Prezi Multimedia based on Problem Based Learning (PBL) in Basic Law of Chemistry material has moment kappa validity about 0,85 with very high level of validity, moment kappa practicality from teacher’s evaluation about 0,86 with very high level of practicality, and moment kappa practicality from student’s evaluation about 0,80 with high level of practicality. The learning media that have been developed is proved valid and practical, so it can be used on Chemistry learning process in class X IPA at SMAN 1 Bukittinggi.