Fluoxetine‐induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15‐deoxy‐Δ 12,14 PGJ 2

2021 ◽  
Author(s):  
Ahmed Ayyash ◽  
Alison C. Holloway
Keyword(s):  
Lipid Accumulation ◽  
Hepatic Lipid ◽  
Prostaglandin Endoperoxide ◽  
Hepatic Lipid Accumulation ◽  
Prostaglandin Endoperoxide Synthase

Protective effects of FXR on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
J Schmitt ◽  
B Kong ◽  
B Stieger ◽  
G Guo ◽  
O Tschopp ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Protective Effects ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

1900-P: Very Low-Density Lipoprotein Ceramides and Hepatic Lipid Accumulation

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1900-P
Author(s):  
JUSTINE M. MUCINSKI
Keyword(s):  
Lipid Accumulation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

Inhibitory Effect of Skate Skin Collagen on Hepatic Lipid Accumulation through Regulation of Lipid Metabolism

2018 ◽  
Vol 47 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Hyun-Jung Lee ◽  
Minji Woo ◽  
Yeong Ok Song ◽  
Jeong Sook Noh
Keyword(s):  
Lipid Metabolism ◽  
Lipid Accumulation ◽  
Inhibitory Effect ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Skin Collagen

Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet

2021 ◽  
Author(s):  
Yilin Liu ◽  
Chunyan Xie ◽  
Zhenya Zhai ◽  
Ze-yuan Deng ◽  
Hugo R. De Jonge ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Fat Accumulation ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Gut Microbiota Composition

This study aimed to investigate the effect of uridine on obesity, fat accumulation in liver, and gut microbiota composition in high-fat diet-fed mice.

Dietary raffinose ameliorates hepatic lipid accumulation induced by cholic acid via modulation of enterohepatic bile acid circulation in rats

2021 ◽  
pp. 1-26
Author(s):  
Kenta Maegawa ◽  
Haruka Koyama ◽  
Satoru Fukiya ◽  
Atsushi Yokota ◽  
Koichiro Ueda ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Bile Acid ◽  
Cholic Acid ◽  
Lipid Accumulation ◽  
Enterohepatic Circulation ◽  
Control Diet ◽  
Hepatic Triglyceride ◽  
Alcoholic Fatty Liver ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

Abstract Enterohepatic circulation of 12α-hydroxylated (12αOH) bile acid (BA) is enhanced depending on the energy intake in high-fat diet-fed rats. Such BA metabolism can be reproduced using a diet supplemented with cholic acid (CA), which also induces simple steatosis, without inflammation and fibrosis, accompanied by some other symptoms that are frequently observed in the condition of non-alcoholic fatty liver in rats. We investigated whether supplementation of the diet with raffinose (Raf) improves hepatic lipid accumulation induced by the CA-fed condition in rats. After acclimation to the AIN-93-based control diet, male Wistar rats were fed diets supplemented with a combination of Raf (30 g/kg diet) and/or CA (0.5 g/kg diet) for 4 weeks. Dietary Raf normalised hepatic triglyceride levels (two-way ANOVA P<0.001 for CA, P=0.02 for Raf, and P=0.004 for interaction) in the CA-supplemented diet-fed rats. Dietary Raf supplementation reduced hepatic 12αOH BA concentration (two-way ANOVA P<0.001 for CA, P=0.003 for Raf, and P=0.03 for interaction). The concentration of 12αOH BA was reduced in the aortic and portal plasma. Raf supplementation increased acetic acid concentration in the caecal contents (two-way ANOVA P=0.001 as a main effect). Multiple regression analysis revealed that concentrations of aortic 12αOH BA and caecal acetic acid could serve as predictors of hepatic triglyceride concentration (R2=0.55, P<0.001). However, Raf did not decrease the secondary 12αOH BA concentration in the caecal contents as well as the transaminase activity in the CA diet-fed rats. These results imply that dietary Raf normalises hepatic lipid accumulation via suppression of enterohepatic 12αOH BA circulation.

Endogenous testosterone reduces hepatic lipid accumulation in protein-restricted male rats

Nutrition ◽  
2020 ◽  
pp. 111130
Author(s):  
Kaito Uchida ◽  
Kana Inoue ◽  
Yukiko Hasegawa ◽  
Fumihiko Hakuno ◽  
Shin-Ichiro Takahashi ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Male Rats ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

Fisetin attenuates high fat diet-triggered hepatic lipid accumulation: A mechanism involving liver inflammation overload associated TACE/TNF-α pathway

2019 ◽  
Vol 53 ◽  
pp. 7-21 ◽  
Author(s):  
Xu Minxuan ◽  
Yan Sun ◽  
Xianling Dai ◽  
Jianxia Zhan ◽  
Tingting Long ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
High Fat Diet ◽  
Liver Inflammation ◽  
High Fat ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Tnf Α
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