Gentamicin-loaded strontium-containing hydroxyapatite bioactive bone cement-An efficient bioactive antibiotic drug delivery system

The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, six independent variables were chosen for Plackett-Burman design. Osmotic agent sodium chloride and microcrystalline cellulose, pore forming agent sodium lauryl sulphate and sucrose, and coating agent ethyl cellulose and cellulose acetate were chosen as independent variables. Optimization of osmotic tablets was done by Box-Behnken design by selecting three independent variables. Osmotic agent sodium chloride, pore forming agent sodium lauryl sulphate, and coating agent cellulose acetate were chosen as independent variables. The result of Plackett-Burman and Box-Behnken design and ANOVA studies revealed that osmotic agent and pore former had significant effect on the drug release up to 12 hr. The observed independent variables were found to be very close to predicted values of most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of porous osmotic pump tablets containing antibiotic drug/s by using sodium chloride, sodium lauryl sulphate, and cellulose acetate as key excipients.

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Liposomes: Current Approaches for Development and Evaluation

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i04.10649 ◽

2017 ◽

Vol 7 (04) ◽

Author(s):

Ashutosh Gupta ◽

Malay Kumar Mandal ◽

Bhupendra Singh ◽

Yashwant Yashwant ◽

Bharat Jhanwar

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

Drug Loading ◽

Triggered Release ◽

Therapeutic Efficiency ◽

Antibiotic Drug ◽

Main Disadvantage ◽

Selection Of

Liposomes (50-1000nm) are the part of a specific type of drug delivery system which is non-toxic and biodegradable in nature. That having ability to reduce the toxicity also enhances the therapeutic efficiency and protects the drug which is encapsulated, from the degradation and immediate dilution. These can be prepared by using various techniques like lipid hydration method, sonication method and solvent injecting method etc. But the selection of technique is depended upon the size of liposome which we want. The main disadvantage of this dosage form is it is very much costly and also having time consuming process. But it has major applications in the form of extrusion for homogeneous size, long circulating liposomes, triggered release liposome, remote drug loading, ligand targeted liposomes and containing combination of drugs. These applications are helpful for advanced drug delivery of anticancer, antifungal and anti-inflammatory drug, the delivery of gene medicine, delivery of anaesthetic and antibiotic drug. The newer researches in this field include hybrid liposomes, phototrigerable liposomes which are fabricated to have the improved functionality. These serves as the upcoming novel nanomedicinal chemotherapy technique.

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Porous calcium phosphate-poly (lactic-co-glycolic) acid composite bone cement: A viable tunable drug delivery system

Materials Science and Engineering C ◽

10.1016/j.msec.2015.09.081 ◽

2016 ◽

Vol 59 ◽

pp. 92-101 ◽

Cited By ~ 24

Author(s):

Abhijit Roy ◽

Siddharth Jhunjhunwala ◽

Emily Bayer ◽

Morgan Fedorchak ◽

Steve R. Little ◽

...

Keyword(s):

Drug Delivery ◽

Calcium Phosphate ◽

Bone Cement ◽

Drug Delivery System ◽

Delivery System ◽

Glycolic Acid ◽

Composite Bone

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A Novel Skeletal Drug Delivery System Using Self-Setting Bioactive Glass Bone Cement IV: Cephalexin Release From Cement Containing Polymer-Coated Bulk Powder

Bio-Medical Materials and Engineering ◽

10.3233/bme-1993-3406 ◽

1993 ◽

Vol 3 (4) ◽

pp. 229-236

Author(s):

Makoto Otsuka ◽

Yoshihisa Matsuda ◽

Tadashi Kokubo ◽

Satoru Yoshihara ◽

Takashi Nakamura ◽

...

Keyword(s):

Drug Delivery ◽

Bioactive Glass ◽

Bone Cement ◽

Drug Delivery System ◽

Delivery System ◽

Bulk Powder

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Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System

Pharmaceutics ◽

10.3390/pharmaceutics13111862 ◽

2021 ◽

Vol 13 (11) ◽

pp. 1862

Author(s):

Emily Dosmar ◽

Gabrielle Vuotto ◽

Xingqi Su ◽

Emily Roberts ◽

Abigail Lannoy ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Transport ◽

3D Model ◽

Release Behavior ◽

Drug Diffusion ◽

Release Drug ◽

Antibiotic Drug

The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste.

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