Intelligent Drug Delivery System for Artificial Bone Cement Based on Hydroxyapatite-Related Organic/Inorganic Composite Materials

2022 ◽  
pp. 231-253
Author(s):  
Makoto Otsuka
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Bone Cement ◽  
Drug Delivery System ◽  
Delivery System ◽  
Artificial Bone ◽  
Inorganic Composite

Fabrication of Bio-Composite Drug Delivery System Using Rapid Prototyping Technology

2007 ◽  
Vol 342-343 ◽  
pp. 497-500 ◽  
Author(s):  
Won Shik Chu ◽  
Sung Geun Kim ◽  
Hyung Jung Kim ◽  
Caroline S. Lee ◽  
Sung Hoon Ahn
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Rapid Prototyping ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Three Dimensional ◽  
Deposition Process ◽  
Porous Microstructure

The rapid prototyping (RP) technology has advanced in various fields such as verification of design, and functional test. Recently, researchers have studied bio-materials to fabricate functional bio-RP parts. In this research, a nano composite deposition system (NCDS) was developed to fabricate three-dimensional functional parts for bio-applications. In the hybrid process, the material removal process by mechanical micro machining and/or the deposition process are combined. NCDS uses biocompatible or biodegradable polymer resin as matrix and various bioceramics to form bio-composite materials. To test drug release rate in vivo environment, two different types of drug delivery system (DDS) were fabricated using the bio-composite materials. 1) Container type DDS used poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil as the drug composite while polycaprolactone(PCL) served as the container of the drug. 2) Scaffold type DDS formed porous microstructure with poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil composite. The effect of geometry of the DDS on release rate of drug is under investigation.

scholarly journals Porous calcium phosphate-poly (lactic-co-glycolic) acid composite bone cement: A viable tunable drug delivery system

2016 ◽  
Vol 59 ◽  
pp. 92-101 ◽  
Author(s):  
Abhijit Roy ◽  
Siddharth Jhunjhunwala ◽  
Emily Bayer ◽  
Morgan Fedorchak ◽  
Steve R. Little ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Drug Delivery System ◽  
Delivery System ◽  
Glycolic Acid ◽  
Composite Bone

A Novel Skeletal Drug Delivery System Using Self-Setting Bioactive Glass Bone Cement IV: Cephalexin Release From Cement Containing Polymer-Coated Bulk Powder

1993 ◽  
Vol 3 (4) ◽  
pp. 229-236
Author(s):  
Makoto Otsuka ◽  
Yoshihisa Matsuda ◽  
Tadashi Kokubo ◽  
Satoru Yoshihara ◽  
Takashi Nakamura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Bone Cement ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bulk Powder

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug
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