scholarly journals Diagnostic Aspects of Vitamin D: Clinical Utility of Vitamin D Metabolite Profiling

JBMR Plus ◽  
2021 ◽  
Author(s):  
Glenville Jones ◽  
Martin Kaufmann
Keyword(s):  
Vitamin D ◽  
Metabolite Profiling ◽  
Clinical Utility ◽  
Diagnostic Aspects

Differential diagnosis of vitamin D‐related hypercalcemia using serum vitamin D metabolite profiling

2021 ◽  
Author(s):  
Martin Kaufmann ◽  
Karl‐Peter Schlingmann ◽  
Linor Berezin ◽  
Arnaud Molin ◽  
Jesse Sheftel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Differential Diagnosis ◽  
Metabolite Profiling ◽  
Serum Vitamin ◽  
Serum Vitamin D

scholarly journals Normocalcemia in the Face of Marked Hypervitaminosis D: The Utility of Vitamin D Metabolite Profiling

2019 ◽  
Vol 4 (2) ◽  
pp. 264-269
Author(s):  
Tomás P Griffin ◽  
Hannah Murray ◽  
Liam Blake ◽  
Damian G Griffin ◽  
Marcia Bell ◽  
...  
Keyword(s):  
Vitamin D ◽  
Metabolite Profiling ◽  
Hypervitaminosis D ◽  
The Face

Antiproliferative and Proapoptotic Effect of Vitamin D in Bortezomib (B) Resistant Human Myeloma Cell Line (HMCL).

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5074-5074
Author(s):  
Asher Alban Chanan-Khan ◽  
Michelle Romano ◽  
Paula Pera ◽  
Noreen Ersing ◽  
Josephia Muindi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Utility ◽  
Progressive Disease ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Antitumor Potential ◽  
Human Myeloma Cell Line ◽  
Induction Of Apoptosis ◽  
Significant Growth Inhibition

Abstract -Introduction: B is a proteasome inhibitor approved for treatment of multiple myeloma (MM) patients. Despite initial clinical efficacy all patients eventually become resistant to bortezomib and die of progressive disease. Development of newer agents with novel antitumor mechanisms is thus warranted. In vitro antiproliferative and proapoptotic effects of vitamin D are reported in various tumor models including MM. This is mediated through vitamin D receptor (VDR) which is also expressed on MM cells. Effect of calcitriol (D3) or its analog paricalcitol (D2) in HMCL resistant to B have not been previously examined. We investigated the antitumor potential of D3 and D2 in HMCL sensitive or resistant to B. Method & Results: HMCL sensitive (OPM-2) or resistant to B (OPM-2/BR) were treated with various concentration of D2 or D3. Significant growth inhibition and induction of apoptosis was noted with D2 and D3 that was maximal at 3 days (p<0.01). This antitumor response was noted despite resistance to B. Treatment of MM cells with vitamin D (D2 or D3) was associated with a loss of full-length PARP, decrease in p21 and induction of p27. Levels of the pro-survival molecules P-Akt and P-Erk were also reduced while total Akt and Erk remain unchanged. Conclusion: We demonstrate that the antiproliferative and proapoptotitc effect of vitamin D in HMCL are mediated through interruption of the Akt pathway and were independent of resistance to B. We have initiated a phase I clinical trial to investigate the clinical utility of paricalcitol in relapsed or refractory MM patients.

scholarly journals Role of Vitamin D in Colorectal Cancer: A Holistic Approach and Review of the Clinical Utility

Cureus ◽  
2020 ◽  
Author(s):  
Moiz Javed ◽  
Aldanah Althwanay ◽  
Farah Ahsan ◽  
Federico Oliveri ◽  
Harshit K Goud ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Clinical Utility ◽  
Holistic Approach

Type V Bekesy Pattern: Interpretation and Clinical Utility

1967 ◽  
Vol 10 (4) ◽  
pp. 733-744 ◽  
Author(s):  
William F. Rintelmann ◽  
Earl R. Harford
Keyword(s):  
Clinical Utility ◽  
The Past ◽  
Type V ◽  
Clinical Cases

Recent studies indicate there is some disagreement concerning the interpretation and clinical utility of the Type V Bekesy pattern. Bekesy tracings obtained over the past six years from a sample of clinical cases were analyzed and a definition was established for the Type V pattern. This definition was applied to Bekesy tracings obtained from normal listeners, hypoacusics, and pseudohypoacusics. The Type V pattern was found frequently among pseudohypoacusics and only rarely among other individuals.

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