scholarly journals Cytokine profiles and clinical characteristics in primary Sjögren´s syndrome patient groups

2020 ◽  
Author(s):  
Erika Fabiola López‐Villalobos ◽  
José Francisco Muñoz‐Valle ◽  
Claudia Azucena Palafox‐Sánchez ◽  
Samuel García‐Arellano ◽  
Diana Emilia Martínez‐Fernández ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Syndrome Patient ◽  
Cytokine Profiles ◽  
Patient Groups

Clinical Characteristics and Cytokine Profiles of Organizing Pneumonia in Patients with Rheumatoid Arthritis Treated with or without Biologics

2016 ◽  
Vol 43 (4) ◽  
pp. 738-744 ◽  
Author(s):  
Hidenaga Kawasumi ◽  
Takahisa Gono ◽  
Eiichi Tanaka ◽  
Hirotaka Kaneko ◽  
Yasushi Kawaguchi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Characteristics ◽  
Corticosteroid Treatment ◽  
Serum Levels ◽  
Interferon Γ ◽  
Interferon Α ◽  
Organizing Pneumonia ◽  
Cytokine Profiles ◽  
Significant Difference ◽  
Inducible Protein

Objective.It has been reported that organizing pneumonia (OP) develops when patients with rheumatoid arthritis (RA) are treated with biologic disease-modifying antirheumatic drugs (bDMARD). However, the clinical characteristics and pathophysiology of OP in RA remain unknown in patients treated with bDMARD. We investigated the clinical characteristics and cytokine profiles of patients with RA-OP treated with bDMARD or conventional synthetic DMARD (csDMARD).Methods.Twenty-four patients with RA who had developed OP were enrolled. These patients included 12 treated with bDMARD (bDMARD-OP subset) and 12 treated with csDMARD (csDMARD-OP subset). We compared the clinical characteristics and cytokine profiles between the patients with OP (OP subset, n = 24) and non-OP patients (non-OP subset, n = 29).Results.There was no significant difference in clinical characteristics between the OP subset and the non-OP subset. Four patients developed OP within 2 months of bDMARD administration. In the other 8 patients, OP developed more than 1 year after the initiation of bDMARD. OP improved with corticosteroid treatment in all bDMARD-OP patients. After OP improved, bDMARD were readministered in 6 patients, and no OP recurrence was observed in any of these patients. Our multivariate analysis revealed that serum levels of interferon-α (IFN-α), interleukin (IL)-1β, IL-6, IL-8, and interferon-γ–inducible protein 10 were significantly associated with the development of OP, although these cytokines tended to be lower in the bDMARD-OP subset than in the csDMARD-OP subset.Conclusion.OP is unlikely to be fatal in patients treated with bDMARD or csDMARD. IFN-α and proinflammatory cytokines are associated with the pathophysiology of OP in RA.

scholarly journals Macrolide Resistance, Clinical Features, and Cytokine Profiles in Taiwanese Children with Mycoplasma pneumoniae Infection

2021 ◽  
Author(s):  
Tsung-Hua Wu ◽  
Nancy M Wang ◽  
Fang-Ching Liu ◽  
Hui-Hsien Pan ◽  
Fang-Liang Huang ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Mycoplasma Pneumoniae ◽  
Clinical Characteristics ◽  
Respiratory Tract Infections ◽  
Macrolide Resistance ◽  
Clinical Severity ◽  
Cytokine Profiles ◽  
Mlva Type ◽  
Tract Infections ◽  
Mycoplasma Pneumoniae Infection

Abstract Background The factors to predict the progression of Mycoplasma pneumoniae infection remain inconclusive. Therefore, we investigated macrolide resistance prevalence, M. pneumoniae genotype, and clinical characteristics of childhood M. pneumoniae respiratory tract infections in Taiwan. Methods A total of 295 children hospitalized with respiratory tract infections with positive serological M. pneumoniae immunoglobulin M test results were enrolled in this 3-year prospective study. Oropharyngeal swabs were obtained for M. pneumoniae cultures and PCR tests. All M. pneumoniae specimens were further characterized by P1 typing, multilocus variable-number tandem-repeat analysis (MLVA), and macrolide resistance genotyping. The clinical characteristics and blood cytokine profiles were analyzed accordingly. Results Of 138 M. pneumoniae specimens, type I P1 was the predominant (136/138, 98.6%). MLVA type P (4-4-5-7-2) was the leading strain (42/138, 30.4%), followed by type J, U, A, and X. The overall macrolide-resistant rate was 38.4% (53/138); the resistance rate increased dramatically yearly: 10.6% in 2017, 47.5% in 2018, and 62.5% in 2019 (P < .001). All macrolide-resistant M. pneumoniae (MRMP) harbored the A2063G mutation and were MLVA type 4-5-7-2 (49/53, 92.5%), especially type U and X. No significant differences in clinical symptoms, duration of hospital stay, and radiographic findings were identified among patients between MRMP and macrolide-sensitive M. pneumoniae (MSMP) groups. Patients with MRMP infection had more febrile days before and during hospitalization; higher IL-13 and IL-33 levels than patients with MSMP infection (P < .005). Conclusions MRMP surged in Taiwan throughout the study period, but macrolide resistance was not a determinant factor of clinical severity.

Clinical characteristics, cytokine profiles and plasma IgE in adults with asthma

2022 ◽  
Vol 143 ◽  
pp. 50-57
Author(s):  
Rathimalar Ayakannu ◽  
Nor Azizan Abdullah ◽  
Vijaya Lechimi Raj ◽  
Ammu K. Radhakrishnan ◽  
Chong Kin Liam
Keyword(s):  
Clinical Characteristics ◽  
Cytokine Profiles

scholarly journals Conjunctival melanoma. What has changed over 55 years?

2013 ◽  
Vol 94 (4) ◽  
pp. 586-588
Author(s):  
E E Grishina ◽  
A M Andreichenko ◽  
O F Fedotova
Keyword(s):  
Clinical Characteristics ◽  
Recent Decade ◽  
Palpebral Fissure ◽  
Bulbar Conjunctiva ◽  
Conjunctival Melanoma ◽  
Clinical Hospital ◽  
Group I ◽  
Equipment Development ◽  
Patient Groups ◽  
Oncological Centers

Aim. To study the changes of conjunctival melanoma clinical characteristics over 55 years according to data of oncological department of Moscow ophthalmological clinical hospital. Methods. The change of conjunctival melanoma clinical characteristics over 55 years was studied. Two patient groups were compared. Group I included patients who were treated and observed in Moscow ophthalmological clinical hospital in 1956-1970, group II included patients who were treated and observed in Moscow ophthalmological clinical hospital in 1982-2013. Medical charts (i.e., case records, clinical histories, pathohistological reports, questionnaires of patients who received beta-applicator therapy etc.) were analyzed. Results. Over 55 years, the prevalence of conjunctival melanoma did not increase. In recent years, conjunctival melanoma has been diagnosed mainly in older patients, however, sex distribution has not changed. Nowadays, small size tumors dominated in primary patients while tumor pigmentation remain unchanged. Tumors localized at corneal limbus and bulbar conjunctiva, i.e. at palpebral fissure, as well as at lacrimal caruncle and plica semilunaris, were still the most frequent, which is associated with intensive insolation of these areas. Total 10-year survival rate in conjunctival melanoma patients was high (80%) over the whole period. Conclusion. Small size tumors predominance indicates that conjunctival pigment tumors diagnostics improved over recent decade due to ophthalmic equipment development, oncological suspicion increase and the possibility to refer patients to specialized ophthalmic oncological centers.

Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children

2019 ◽  
Vol 21 (10) ◽  
pp. 749-754 ◽  
Author(s):  
Chen Yuan ◽  
Fang-Mei Min ◽  
Yin-Jie Ling ◽  
Gang Li ◽  
Hong-Zhou Ye ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Dna Sequencing ◽  
Mycoplasma Pneumoniae ◽  
Clinical Characteristics ◽  
Chinese Patients ◽  
23S Rrna ◽  
Rrna Gene ◽  
23S Rrna Gene ◽  
Patient Groups ◽  
Mycoplasma Pneumoniae Pneumonia

Aim: To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods: A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Infection with M. pneumoniae was confirmed by ELISA for M. pneumoniae antibody, PCR, and throat culture. Antibiotic resistance was measured from the minimum inhibitory concentrations (MICs) of antibiotics. The 23S rRNA gene of M. pneumoniae was also examined for mutations using DNA sequencing. Patients with MP were classified into antibiotic resistance (n = 98) and no resistance (n = 20) groups. For the 98 patients showing antibiotic resistance, they were further stratified into subgroups based on the antibiotics initially prescribed: azithromycin or erythromycin (n = 78) and cephalosporin or penicillin (n = 20). Clinical characteristics were compared between the patient groups. Results: Antibiotic resistance group presented significantly longer febrile days compared to the no resistance group (P = 0.007). The number of febrile days after macrolide treatment was also longer in antibiotic resistance group than in no resistance group (P = 0.042). MP patients initially treated with azithromycin or erythromycin showed a longer average duration of respiratory symptoms (P = 0.046) and had a fever for more days after macrolide treatment (P = 0.009) compared to those received cephalosporin or penicillin. The average white blood cell count of patients treated with azithromycin or erythromycin was nearly half of those treated with cephalosporin or penicillin (P < 0.001). Nearly 90% of the resistant M. pneumoniae strains showed A to G substitution at position 2063 of the 23S rRNA gene. Conclusion: The clinical characteristics and antibiotic resistance of MP were analyzed in 120 Chinese patients. DNA sequencing revealed a highly prevalent A2063G mutation in the 23S rRNA gene.

Global Cytokine Profiles and Association With Clinical Characteristics in Patients With Irritable Bowel Syndrome

2016 ◽  
Vol 111 (8) ◽  
pp. 1165-1176 ◽  
Author(s):  
Sean M P Bennet ◽  
Annikka Polster ◽  
Hans Törnblom ◽  
Stefan Isaksson ◽  
Sandrine Capronnier ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Characteristics ◽  
Cytokine Profiles ◽  
Irritable Bowel

scholarly journals Correlation analysis between JAK2, MPL, and CALR mutations in patients with myeloproliferative neoplasms of Chinese Uygur and Han nationality and their clinical characteristics

2018 ◽  
Vol 46 (11) ◽  
pp. 4650-4659
Author(s):  
Tao Lang ◽  
Yuling Nie ◽  
Zengsheng Wang ◽  
Qin Huang ◽  
Li An ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Fusion Gene ◽  
Myeloproliferative Neoplasms ◽  
Pcr Amplification ◽  
Jak2 V617f ◽  
Janus Kinase ◽  
Chinese Patients ◽  
Patient Groups ◽  
Calr Mutations ◽  
The Relationship

Background Genetic factors play a role in the etiology of BCR-ABL-negative myeloproliferative neoplasms (MPNs). This study explored the relationship between mutations in the Janus kinase 2 gene ( JAK2), MPL, and the calreticulin gene ( CALR) in Uygur and Han Chinese patients with BCR-ABL fusion gene-negative MPN and corresponding clinical features. Methods A total of 492 BCR-ABL-negative MPN patients treated in our hospital from May 2013 to August 2016 were enrolled. Genomic DNA was extracted from peripheral blood and used for PCR amplification and DNA sequencing. Mutations including JAK2 V617F, MPL W515L/K, and those in JAK2 exon 12 and CALR were analyzed and compared with patient clinical characteristics. Results Of the 492 MPN patients, 169 were Uygur and 323 were Han. In these two patient groups, JAK2 mutations were detected in 39.64% and 52.63%, respectively, CALR mutations were detected in 10.06% and 20.43%, respectively, and MPL mutations were detected in 0.93% of Han patients. The age, white blood cell count, platelet levels, and hemoglobin levels in JAK2 in Han patients were higher than those in Uygur patients. Conclusion Han MPN patients harboring JAK2 mutations had higher level of age, WBC, PLT, and Hb than Uyghur patients with the same mutations.

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