Contribution of functional voltage-gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: II. Secretory membrane activity

2003 ◽  
Vol 195 (3) ◽  
pp. 461-469 ◽  
Author(s):  
M.E. Mycielska ◽  
S.P. Fraser ◽  
M. Szatkowski ◽  
M.B.A. Djamgoz
Keyword(s):  
Prostate Cancer ◽  
Na Channel ◽  
Cell Behaviors ◽  
Metastatic Cascade ◽  
Voltage Gated ◽  
Membrane Activity ◽  
Channel Expression ◽  
Rat Prostate

Resveratrol: Inhibitory Effects on Metastatic Cell Behaviors and Voltage-Gated Na+Channel Activity in Rat Prostate Cancer In Vitro

2014 ◽  
Vol 66 (6) ◽  
pp. 1047-1058 ◽  
Author(s):  
Scott Paton Fraser ◽  
Alex Peters ◽  
Sian Fleming-Jones ◽  
Dev Mukhey ◽  
Mustafa Bilgin Ali Djamgoz
Keyword(s):  
Prostate Cancer ◽  
Na Channel ◽  
Channel Activity ◽  
Inhibitory Effects ◽  
Cell Behaviors ◽  
Voltage Gated ◽  
Metastatic Cell ◽  
Rat Prostate

scholarly journals Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+channel activity

2008 ◽  
Vol 215 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Yanning Ding ◽  
William J. Brackenbury ◽  
Pinar U. Onganer ◽  
Ximena Montano ◽  
Louise M. Porter ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Na Channel ◽  
Channel Activity ◽  
Prostate Cancer Cells ◽  
Voltage Gated ◽  
Epidermal Growth ◽  
Rat Prostate

A Study of Membrane Activity in Rat Prostate Cancer Cells: An Evaluation of the FM1–43 Dye Technique

2000 ◽  
Vol 20 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Maria E. Mycielska ◽  
Monika Schäfer ◽  
Scott P. Fraser ◽  
Mustafa B. A. Djamgoz ◽  
C. Lindsay Bashford
Keyword(s):  
Prostate Cancer ◽  
Cell Division ◽  
Cancer Cells ◽  
Cell Lines ◽  
Prostate Cancer Cells ◽  
Excitable Cells ◽  
Membrane Activity ◽  
Variable Pattern ◽  
Cells In Culture ◽  
Rat Prostate

A study was initiated to test whether the FM1–43 dye technique could beapplied to the study of endocytic membrane activity in two rodent prostatecancer (MAT-LyLu and AT-2) cell lines of markedly different metastaticability. The lipophilic dye FM1–43, which has frequently been used tomonitor endo/exocytic activity in excitable cells was employed. We found,as in excitable tissues, that both strongly metastatic (MAT-LyLu) andweakly metastatic (AT-2) cells in culture take up FM1–43 to give vesicularstaining of a variable pattern, which appeared to differ between the twocell lines. However, unlike excitable tissues, neither cell linesubsequently released the dye. Indeed, both cell lines retained the dyethrough several rounds of cell division suggesting that dye incorporatedby cells does not enter the endo/exocytotic cycle. Uptake of dye wasindependent of temperature, Na+/K+ gradients, pH or metabolism. Wesuggest that passive accumulation of FM1–43 can occur in cancer cells andshould not, automatically, be interpreted as evidence of endocytosis.

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