Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall

2020 ◽  
Author(s):  
Yanan Guo ◽  
Binjie Yan ◽  
Yu Gui ◽  
Zhihan Tang ◽  
Shi Tai ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Vascular Wall ◽  
Potential Impact

scholarly journals The role of oxygen transport in atherosclerosis and vascular disease

2020 ◽  
Vol 17 (165) ◽  
pp. 20190732 ◽  
Author(s):  
John Tarbell ◽  
Marwa Mahmoud ◽  
Andrea Corti ◽  
Luis Cardoso ◽  
Colin Caro
Keyword(s):  
Blood Flow ◽  
Vascular Disease ◽  
Oxygen Transport ◽  
Intimal Hyperplasia ◽  
Hypoxia Inducible Factor ◽  
Vascular Diseases ◽  
Vascular Wall ◽  
Vasa Vasorum ◽  
Mechanical Factors

Atherosclerosis and vascular disease of larger arteries are often associated with hypoxia within the layers of the vascular wall. In this review, we begin with a brief overview of the molecular changes in vascular cells associated with hypoxia and then emphasize the transport mechanisms that bring oxygen to cells within the vascular wall. We focus on fluid mechanical factors that control oxygen transport from lumenal blood flow to the intima and inner media layers of the artery, and solid mechanical factors that influence oxygen transport to the adventitia and outer media via the wall's microvascular system—the vasa vasorum (VV). Many cardiovascular risk factors are associated with VV compression that reduces VV perfusion and oxygenation. Dysfunctional VV neovascularization in response to hypoxia contributes to plaque inflammation and growth. Disturbed blood flow in vascular bifurcations and curvatures leads to reduced oxygen transport from blood to the inner layers of the wall and contributes to the development of atherosclerotic plaques in these regions. Recent studies have shown that hypoxia-inducible factor-1α (HIF-1α), a critical transcription factor associated with hypoxia, is also activated in disturbed flow by a mechanism that is independent of hypoxia. A final section of the review emphasizes hypoxia in vascular stenting that is used to enlarge vessels occluded by plaques. Stenting can compress the VV leading to hypoxia and associated intimal hyperplasia. To enhance oxygen transport during stenting, new stent designs with helical centrelines have been developed to increase blood phase oxygen transport rates and reduce intimal hyperplasia. Further study of the mechanisms controlling hypoxia in the artery wall may contribute to the development of therapeutic strategies for vascular diseases.

Immunology of the vessel wall

2017 ◽  
Author(s):  
Göran K. Hansson
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Vascular Disease ◽  
Vessel Wall ◽  
Vascular Diseases ◽  
Vascular Wall ◽  
Point Of View ◽  
Health And Disease ◽  
Inflammatory Vascular Disease

This chapter provides an overview of the vascular wall and its cells from an immunological point of view, discusses the capacity of vascular cells to promote and regulate immune responses, and outlines interactions between the vasculature and the immune system in health and disease. The role of immune mechanisms in vascular diseases is discussed, with a focus on atherosclerosis, a chronic inflammatory vascular disease.

Exercise-Induced Fibrinolysis – Fact or Fiction?

1982 ◽  
Vol 48 (02) ◽  
pp. 201-203 ◽  
Author(s):  
N A Marsh ◽  
P J Gaffney
Keyword(s):  
Plasminogen Activator ◽  
Degradation Products ◽  
Coagulation Factors ◽  
Vascular Wall ◽  
Strenuous Exercise ◽  
Fibrin Degradation Products ◽  
Real Increase ◽  
Exercise Induced ◽  
Male Subjects

SummaryThe effect of strenuous exercise on the fibrinolytic and coagulation mechanisms was examined in six healthy male subjects. Five min bicycle exercise at a work-rate of 800 to 1200 kpm. min−1 produced an abrupt increase in plasma plasminogen activator levels which disappeared after 90 min. However, there was no change in early or late fibrin degradation products nor was there a change in fibrinopeptide A levels or βthromboglobulin levels after exercise although activated partial thromboplastin times were significantly shortened. It is concluded that strenuous exercise does not produce any real increase in fibrinogen-fibrin conversion nor any real increase in the breakdown of these proteins. The role of exercise-induced release of plasminogen activator remains unclear, but probably helps to maintain plasma levels in a discontinuous manner concurrently with the continuous low-level secretion from the vascular wall. The shortening of partial thromboplastin time may be due to the raised levels of plasminogen activator changing the activation state of other coagulation factors.

Theoretical and Empirical Research in Modern Economics: Problems of Communication

2008 ◽  
pp. 4-19 ◽  
Author(s):  
A. Libman
Keyword(s):  
Empirical Research ◽  
Econometric Methods ◽  
Potential Impact ◽  
Empirical Turn

The last decades witnessed the increasing importance of econometric methods and empirical research in economics. The success of the empirical turn in economics depends on the formats and problems of communication between theory and empirics. The paper considers potential difficulties in communication "from the theory to empirical research" and "from empirical research to theory". It analyzes the role of informal consensus as an instrument facilitating such communication and potential impact of this consensus on the direction of research.

Disseminated intravascular coagulation syndrome

2020 ◽  
pp. 22-40
Author(s):  
A. Kulikov
Keyword(s):  
Clinical Practice ◽  
Disseminated Intravascular Coagulation ◽  
Blood Cells ◽  
Physical State ◽  
Clinical Manifestations ◽  
Vascular Wall ◽  
Stages Of Development ◽  
Intravascular Coagulation ◽  
Hemostatic Disorder

Presented material reveals main links in the pathogenesis of hemostatic disorder. In particular, attention is paid to the role of the lungs, liver and other organs in the development of this process. Role of vascular wall and blood cells in regulation of the physical state of blood is described in detail. The most frequent factors leading to hypercoagulation are indicated. Difference between hypercoagulation and thrombophilia is shown. The latter is found in clinical practice quite often, but at the same time, it is poorly diagnosed. Such a terrible complication of hemostatic disorder as disseminated intravascular coagulation is described. Its classification, stages of development, clinical manifestations are offered to the readers.

The role of NADPH Oxidase in Vascular Disease – Hypertension, Atherosclerosis & Stroke

2015 ◽  
Vol 21 (41) ◽  
pp. 5933-5944 ◽  
Author(s):  
Stephen Gray ◽  
Karin Jandeleit-Dahm
Keyword(s):  
Nadph Oxidase ◽  
Vascular Disease

The role of Digitally Reconstructed Radiographs in the verification process

1999 ◽  
Vol 1 (3) ◽  
pp. 103-108 ◽  
Author(s):  
N. S. Stanley
Keyword(s):  
Digital Imaging ◽  
Digitally Reconstructed Radiographs ◽  
Verification Methods ◽  
Digital Imaging Technology ◽  
Potential Impact ◽  
Portal Images ◽  
Verification Process ◽  
Effective Representation ◽  
Radiotherapy Treatment

This article reviews the development and potential impact of Digitally Reconstructed Radiographs (DRR's) in the planning and verification of radiotherapy treatments. It explores the requirements for the creation of usable DRR's their integration into current verification methods and it highlights some of the factors that may influence the routine use of DRR's. Continuing developments in radiotherapy techniques demand increasingly accurate verification methods. DRR's provide an efficient and effective representation of planned treatments for comparison with both simulator and portal images, encompassing the digital imaging technology which is the future of radiotherapy treatment verification.

Transgenic mouse model for evaluation of the role of cyclin-dependent kinase 8 in vascular disease

2021 ◽  
Vol 331 ◽  
pp. e62
Author(s):  
E. Varlamova ◽  
A. Bruter ◽  
V. Mogila ◽  
I. Roninson ◽  
A. Deykin
Keyword(s):  
Mouse Model ◽  
Vascular Disease ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Cyclin Dependent Kinase

Role of Biomarkers in Developing New Therapies for Vascular Disease

2007 ◽  
Vol 31 (4) ◽  
pp. 676-681 ◽  
Author(s):  
Vijay Nambi ◽  
Christie M. Ballantyne
Keyword(s):  
Vascular Disease ◽  
New Therapies
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