Evaluation of the Effect of Mannuronic Acid as a Novel NSAID with Immunosuppressive Properties on Expression of SOCS1, SOCS3, SHIP1 and TRAF6 Genes and Serum Level of IL‐6 and TNF‐α in Patients with Multiple Sclerosis

2021 ◽  
Author(s):  
Soheil Najafi ◽  
Payam Saadat ◽  
Nahid Beladi Moghadam ◽  
Ali Manoucherinia ◽  
Zahra Aghazadeh ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Level ◽  
Mannuronic Acid ◽  
Tnf Α

Genetic Variation in TNF-α, its Relation with Inflammatory Biomarkers and Susceptibility to Rheumatoid Arthritis

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Khadiga Ahmed Ismail
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Level ◽  
Functional Disability ◽  
Serum Levels ◽  
Amplification Refractory Mutation System ◽  
Reactive Protein ◽  
Tnf Α ◽  
Mutation System ◽  
Potential Factor ◽  
Factor Α

Background: Tumor necrosis Factor-α (TNF-α) is encoded and controlled by TNF-α gene, which is involved in rheumatoid arthritis (RA) susceptibility. This research aimed to identify genetic variations of TNF-α (G308A) and to establish its association with inflammatory markers in Rheumatoid Arthritis predisposition. Methods: In the present study, fifty RA patients and fifty volunteers were involved and evaluated for the C-reactive protein, rheumatoid factor, and TNF-α were estimated by ELISA, Erythrocyte Sedimentation Rate (ESR) by Wintergreen method and for TNF-α-308 G>A polymorphism by polymerase chain reaction with amplification refractory mutation system (PCR-ARMS). Results: The CRP, RF, ESR and TNF-α were significantly elevated in RA patients relative to controls. The serum level TNF-α was also significantly elevated in female patients and in patients ≥50 years. Analysis of TNF-308 gene polymorphism revealed that GG genotypes were more prevalent in RA patients than in the healthy individuals and that GG genotype may be a potential factor to RA. The G allele was more common in RA than in the control. Elevated TNF-α serum levels were significantly associated the GG genotype and functional disability in RA patients. Conclusion: TNF-α promoter 308polymorphism GG genotype may be considered as a risk factor for RA and the TNF-α serum level was significantly related to the functional disability in the disease.

Assessment of biochemical determinants in Multiple Sclerosis patients following the oral administration of β-D-Mannuronic acid [M2000]

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamad Reza Nikouei Moghaddam ◽  
Monireh Movahedi ◽  
Maryam Bananej ◽  
Soheil Najafi ◽  
Nahid Beladi Moghadam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Uric Acid ◽  
Vitamin D3 ◽  
Chronic Inflammatory Disease ◽  
Toxic Effects ◽  
Control Group ◽  
Therapeutic Effects ◽  
Mannuronic Acid ◽  
Anti Inflammatory ◽  
Multiple Sclerosis Patients

Background: Multiple sclerosis is an autoimmune chronic inflammatory disease of the central nervous system that can lead to some serious disabilities. Despite using various immunomodulatory and anti-inflammatory drugs that have therapeutic effects, they cannot reduce its progression completely, and have some unwanted side effects too. The immunomodulatory and anti-inflammatory effects of the β-D-Mannuronic acid [M2000] have been proven in several surveys, and the present research was designed to determine its toxicity and therapeutic effects in MS patients. Methods: This study was performed on 15 MS patients who took 25 mg/kg/day the oral form of the β-D-Mannuronic acid for six months, and 15 healthy people as a control group. Serum levels of Urea, Creatinine, GGT, Vitamin D3, Uric acid, and Anti-Phospholipids were compared to evaluate the therapeutic and possible toxic effects of this drug after this period. Results: Non- toxic effects through the study of Urea, Creatinine, GGT, and non-significant changes in Uric acid and AntiPhospholipids levels, besides a significant rise in Vitamin, D3 levels in the M2000 treated cases were found. Conclusions: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients.

scholarly journals Pleiotrophin serum level is increased in Relapsing-Remitting Multiple Sclerosis and correlates with sex, BMI and treatment

2021 ◽  
Author(s):  
María Paulina Reyes-Mata ◽  
Argelia Esperanza Rojas-Mayorquín ◽  
Lucrecia Carrera-Quintanar ◽  
Celia González-Castillo ◽  
Mario Alberto Mireles-Ramírez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Level ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Correlation between TNF-α- serum level and TNF-α -308 gene polymorphism in Iraqi patients with type 2 diabetes mellitus

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101136
Author(s):  
Sarah Rahman Rasool ◽  
Othman Taha Qasim ◽  
Salaam Khudhur Muslem ◽  
Muataz Mohammed Al-Taee
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Level ◽  
Gene Polymorphism ◽  
Tnf Α

scholarly journals Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial

Life ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 267
Author(s):  
Gabriela Angelova ◽  
Tereza Skodova ◽  
Terezie Prokopiusova ◽  
Magdalena Markova ◽  
Natalia Hruskova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Physical Therapy ◽  
Serum Level ◽  
Clinical Outcomes ◽  
Endocrine System ◽  
Motor Program ◽  
Neuroactive Steroids ◽  
Patient Reported ◽  
Serial Addition ◽  
Post Assessment

Background: Only few studies have monitored the potential of physical activity training and physical therapy to modulate the reaction of the endocrine system. In this study, the effect of neuroproprioceptive facilitation and inhibition physical therapy on clinical outcomes and neuroactive steroids production in people with multiple sclerosis was evaluated. Moreover, we were interested in the factors that influence the treatment effect. Methods: In total, 44 patients with multiple sclerosis were randomly divided into two groups. Each group underwent a different kind of two months ambulatory therapy (Motor program activating therapy and Vojta’s reflex locomotion). During the following two months, participants were asked to continue the autotherapy. Primary (serum level of cortisol, cortisone, 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, DHEA) and secondary (balance, cognition and patient-reported outcomes) outcomes were examined three times (pre, post, and washout assessments). Results: In both groups, there is a decreasing trend of 7-oxo-DHEA concentration in post-assessment and 7β-OH-DHEA in washout versus pre-assessment. A higher impact on neuroactive steroids is visible after Vojta’s reflex locomotion. As for clinical outcomes, the Paced Auditory Serial Addition Test and Multiple Sclerosis Impact Scale significantly improved between post-assessment and washout assessment. The improvement was similar for both treatments. Conclusions: Neuroproprioceptive facilitation and inhibition improved the clinical outcomes and led to non-significant changes in neuroactive steroids. Trial registration (NCT04379193).

scholarly journals Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D3

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Natalia Niedziela ◽  
Krystyna Pierzchała ◽  
Jolanta Zalejska-Fiolka ◽  
Jacek T. Niedziela ◽  
Ewa Romuk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Calcium Phosphate ◽  
Serum Level ◽  
Clinical Stage ◽  
Phosphate Metabolism ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Calcium Phosphate Metabolism

Background. In addition to the widely known effect of vitamin D3 (vitD3) on the skeleton, its role in the regulation of the immune response was also confirmed. Aim. The assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with relapsing-remitting multiple sclerosis (RRMS) selected due to the serum level of vitamin D3. Methods. The concentrations of biochemical markers and indices of lumbar spine bone densitometry (DXA) were determined in 82 patients divided into vitamin D3 deficiency (VitDd), insufficiency (VitDi), and normal vitamin D3 level (VitDn) subgroups. Results. The highest level of the parathyroid hormone (PTH) and the highest prevalence of hypophosphatemia and osteopenia were demonstrated in VitDd group compared to VitDi and VitDn. However, in VitDd, VitDi, and VitDn subgroups no significant differences were observed in the levels of alkaline phosphatase (ALP) and ionized calcium (Ca2+) and in DXA indices. A negative correlation was observed between the level of vitamin D3 and the Expanded Disability Status Scale (EDSS) in the whole MS group. The subgroups were significantly different with respect to the EDSS scores and the frequency of complaints related to walking according to the EQ-5D. Conclusions. It is necessary to assess calcium-phosphate metabolism and supplementation of vitamin D3 in RRMS patients. The higher the clinical stage of the disease assessed with the EDSS, the lower the level of vitamin D3 in blood serum. Subjectively reported complaints related to difficulties with walking were reflected in the EDSS in VitDd patients.

Elevated serum level of IL-4 in neuromyelitis optica and multiple sclerosis patients

2019 ◽  
Vol 40 (5) ◽  
pp. 555-563
Author(s):  
Soheil Tahani ◽  
Leila Dehghani ◽  
Hamidreza Jahanbani-Ardakani ◽  
Vahid Shaygannejad ◽  
Ali Fazli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Level ◽  
Neuromyelitis Optica ◽  
Elevated Serum ◽  
Elevated Serum Level ◽  
Multiple Sclerosis Patients

scholarly journals Effect of TNF-α −308G/A (rs1800629) Promoter Polymorphism on the Serum Level of TNF-α Among Iraqi Patients with Generalized Vitiligo

2020 ◽  
Vol Volume 13 ◽  
pp. 825-835
Author(s):  
Ronak Ahmed ◽  
Dana Sharif ◽  
Mohammad Jaf ◽  
Dashty Mohammed Amin
Keyword(s):  
Serum Level ◽  
Promoter Polymorphism ◽  
Tnf Α

-308 G > A of TNF-α gene promoter decreases the risk of multiple sclerosis: a meta-analysis

2010 ◽  
Vol 17 (6) ◽  
pp. 658-665 ◽  
Author(s):  
Yan Yang ◽  
Rulin Sun ◽  
Heng Yang ◽  
Fang Zheng ◽  
Feili Gong
Keyword(s):  
Multiple Sclerosis ◽  
Genetic Factors ◽  
Association Studies ◽  
Meta Analysis ◽  
Low Frequency ◽  
Gene Promoter ◽  
Tnf Α ◽  
Control Association ◽  
Necrosis Factor ◽  
Reduced Risk

Background: Environmental and genetic factors are thought to be involved in the pathogenesis of multiple sclerosis (MS). Polymorphisms of tumor necrosis factor (TNF)-α −308 were implicated in MS risk in several case–control association studies. However, the studies have shown inconsistent results. Objectives: To address the association of G/A polymorphisms of TNF-α −308 with MS risk by meta-analysis. Methods: Thirteen studies were included. Pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated. Results: A total of 1870 cases and 2769 controls were included in the meta-analysis. The pooled result indicated that −308 A allele is significantly associated with reduced risk of MS compared with −308 G allele (A vs. G, p = 0.022). The same pattern of the result was also obtained in the contrasts of AA + GA vs. GG ( p = 0.008) and GA vs. GG ( p = 0.007). For AA vs. GG or AA vs. GA + GG, no significant association was detected most likely caused by very low frequency or non-availability of homozygote genotype AA for all of the studies. Conclusions: TNF-α −308 A allele is associated with reduced risk of MS.

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