The “Two‐Step” approach for classifying the severity of acute pancreatitis: a retrospective study

Author(s):  
Yun Zhang ◽  
Cheng Zhang ◽  
Wen‐Qiao Yu ◽  
Zhi‐En Wang ◽  
Jian Zhang ◽  
...  
2020 ◽  
Vol 7 (4) ◽  
pp. 180
Author(s):  
Federico Puccini Leoni ◽  
Tina Pelligra ◽  
Simonetta Citi ◽  
Veronica Marchetti ◽  
Eleonora Gori ◽  
...  

Abdominal ultrasound examinations (AUEs) are commonly used in the diagnostic evaluation of canine acute pancreatitis (AP). The purpose of this retrospective study was to evaluate and monitor the ultrasonographic changes observed in dogs with clinically suspected AP on consecutive AUEs. The study population was constituted by 38 client-owned dogs hospitalized for no less than 48 h from January 2016 to December 2019. Dogs included in this study were suspected of AP based on the clinical examination and abnormal rapid specific canine pancreatic lipase test performed at admission. Dogs were submitted to two AUEs, the first on the first day of hospitalization, and the second between 40–52 h after the first one. Twelve dogs had both AUEs suggestive of AP. Fourteen dogs received an ultrasonographic diagnosis of AP exclusively on the second AUE. Twelve dogs remained negative on both the first and the second AUE. In 26 out of 38 patients the second AUE was suggestive of AP. If a patient is suspected of AP, it is advisable to carry out ultrasonographic monitoring at least within the first 52 h after admission, since ultrasonographic signs of AP may only become observable later after hospitalization.


PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216562 ◽  
Author(s):  
Chao-Nan Liu ◽  
Si Chen ◽  
Hao Chen ◽  
Li Yue ◽  
Li-Qin Ling ◽  
...  

Pancreatology ◽  
2017 ◽  
Vol 17 (4) ◽  
pp. S54
Author(s):  
Horacio Rilo ◽  
Peter Nauka ◽  
G. Stoffels ◽  
Rachel Gray ◽  
B. Villacres ◽  
...  

2021 ◽  
Vol 27 ◽  
Author(s):  
Quan-Xiang Zeng ◽  
Zhen-Hua Wu ◽  
Dong-Liang Huang ◽  
Ye-Sheng Huang ◽  
Hao-Jie Zhong

2021 ◽  
Vol Volume 14 ◽  
pp. 9483-9489
Author(s):  
Xingming Liu ◽  
Guoxin Guan ◽  
Xinye Cui ◽  
Yaqing Liu ◽  
Yinghan Liu ◽  
...  

2021 ◽  
Vol 16 (2) ◽  
pp. 248-253
Author(s):  
Valentina-Daniela COMĂNICI ◽  
◽  
Ioana Florentina CODREANU ◽  
Anca BĂLĂNESCU ◽  
Alina Angelica BELIVACĂ ◽  
...  

One of the affected organs in cystic fibrosis (CF) is the pancreas, mainly translated into exocrine pancreatic insufficiency. Although rare, acute pancreatitis (AP) has been described, mostly in pancreatic sufficient patients. Objectives. Estimating AP prevalence in CF pediatric population of the I.N.S.M.C. „AlessandrescuRusescu” CF centre. Material and methods. 5 year retrospective study (2011-2016) including INSMC CF centre pediatric population aged 3-18 years. PA diagnosis was established on the presence of minimum 2 criteria between: characteristic abdominal pain, x3 normal value for age elevation of amylase/lipase, medical imaging evaluation suggestive for AP. Patients were evaluated with different criteria including PIP score of predicting AP risk. Outcomes. 48 patients were included with a slight female predominance (54%). 3 of them presented diagnostic criteria for AP (6,25%), all heaving pancreatic insufficiency and high PIP score (low risk of developing AP); 2 of them have low compliance with pancreatic enzymes substitution therapy; one of them presented recurrent episodes of AP. Conclusions. AP is a rare CF complication. It can be easily missed due to a large number of abdominal pain and emesis causes in CF patients. Although it is usually associated with pancreatic sufficiency, all our patients were pancreatic insufficient.


2020 ◽  
Author(s):  
weiming xiao ◽  
Weili Liu ◽  
Ling Yin ◽  
Yong Li ◽  
Guotao Lu ◽  
...  

Abstract Background: To investigate the value of serum hydroxybutyrate dehydrogenase (HBDH) level, an isozyme of lactate dehydrogenase (LDH), in evaluating the severity of acute pancreatitis (AP).Methods: Patients diagnosed with AP from January 2013 to December 2018 were included in this retrospective study. Patients were divided into the normal serum HBDH levels group (n-HBDH group) and the high serum HBDH levels group (h-HBDH group) according to the criteria HBDH ≥ 182 U/L after admission. The demographic parameters, laboratory data and the severity of AP in the two groups were compared. The receiver operating curve (ROC) was used to evaluate the efficacy of serum HBDH in predicting persistent organ failure and systemic inflammatory response syndrome (SIRS).Results: A total of 260 AP patients were enrolled, including 176 cases in the n-HBDH group and 84 cases in the h-HBDH group. The incidence of SIRS and organ failure in the h-HBDH group were significantly higher than those in n-HBDH group (both P < 0.001). In addition, the HBDH level was significantly decreased in 110 patients who were re-measured after AP treatment. The serum HBDH levels were positively correlated with Atlanta classification, Ranson score, and BISAP score (all P < 0.05). ROC analysis showed that a serum HBDH cut-off point of 195.0 U/L had optimal predictive value for the development of persistent organ failure (AUC = 0.778) and 166.5 U/L for the development of SIRS (AUC = 0.724).Conclusion: The elevated serum HBDH in early stage of AP is closely related to the adverse prognosis of AP patients, which can be used as a potential early biomarker for predicting the severity of AP.


2020 ◽  
Vol 26 (4) ◽  
pp. 216
Author(s):  
Mohamad Mubder ◽  
Banreet Dhindsa ◽  
Danny Nguyen ◽  
Syed Saghir ◽  
Chad Cross ◽  
...  

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