Arterial wall MRI characteristics are associated with elevated serum markers of inflammation in humans

2001 ◽  
Vol 14 (6) ◽  
pp. 698-704 ◽  
Author(s):  
Clifford R. Weiss ◽  
Andrew E. Arai ◽  
Minh N. Bui ◽  
Kwabena O. Agyeman ◽  
Myron A. Waclawiw ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Elevated Serum ◽  
Serum Markers ◽  
Markers Of Inflammation ◽  
Mri Characteristics

Circulating progenitor cells in patients with atrial fibrillation and their relation with serum markers of inflammation and angiogenesis

2010 ◽  
Vol 104 (08) ◽  
pp. 327-334 ◽  
Author(s):  
Andrew Blann ◽  
Timothy Watson ◽  
Eduard Shantsila ◽  
Gregory Lip
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Progenitor Cells ◽  
Cell Population ◽  
Fas Ligand ◽  
Serum Markers ◽  
Endothelial Damage ◽  
Stepwise Multiple Regression ◽  
Soluble Fas ◽  
Markers Of Inflammation

Summary The pathophysiological inter-relationships and underlying ‘drivers’ of a prothrombotic state in atrial fibrillation (AF) are complex but may include endothelial abnormalities. Circulating progenitor cells (CPCs) have been recently described as a cell population that may promote repair of endothelial damage. We hypothesised abnormalities in this cell population, alongside abnormal markers of endothelial damage/dysfunction (von Willebrand factor, soluble E-selectin), apoptosis (soluble Fas, soluble Fas ligand), angiogenesis (vascular endothelial growth factor) and inflammation (interleukin-6) in 135 consecutive AF patients (14 with lone AF), who were compared to 33 ‘disease controls’ and 13 healthy controls. We also explored whether restoration of sinus rhythm would alter these indices. No significant differences in research indices were observed between AF and disease controls, apart from soluble Fas levels (p<0.001). Median CPC levels in lone AF were higher compared to ‘non-lone AF’ (that is, AF patients with co-morbidities) [p<0.001], apparently because of difference in age and presence of co-morbidities. There was an increase in CPC counts (p=0.007), but in not other markers following DC cardioversion. CPCs increased significantly in the 17 patients who were successfully cardioverted into sinus rhythm (p=0.003). In a stepwise multiple regression analysis, age (p=0.014), hyperlipidaemia (p=0.001) and use of statins (but not AF) was predictive of CPC counts (p=0.014). In conclusion, AF is unlikely to be independently associated with abnormalities in CPCs. Successful cardioversion is associated with a modest but significant increase in CPCs.

scholarly journals Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid– and ɣ-linolenic acid–containing botanical oils

2020 ◽  
Vol 111 (5) ◽  
pp. 1068-1078 ◽  
Author(s):  
Susan Sergeant ◽  
Brian Hallmark ◽  
Rasika A Mathias ◽  
Tammy L Mustin ◽  
Priscilla Ivester ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Linolenic Acid ◽  
Elevated Serum ◽  
Fatty Acid Desaturase ◽  
Borage Oil ◽  
Dependent Manner ◽  
Double Blind ◽  
Borago Officinalis ◽  
Markers Of Inflammation ◽  
The Impact

ABSTRACT Background Unexplained heterogeneity in clinical trials has resulted in questions regarding the effectiveness of ɣ-linolenic acid (GLA)-containing botanical oil supplements. This heterogeneity may be explained by genetic variation within the fatty acid desaturase (FADS) gene cluster that is associated with circulating and tissue concentrations of arachidonic acid (ARA) and dihomo-ɣ-linolenic acid (DGLA), both of which may be synthesized from GLA and result in proinflammatory and anti-inflammatory metabolites, respectively. Objectives The objective of this study was to prospectively compare the capacity of a non-Hispanic white cohort, stratified by FADS genotype at the key single-nucleotide polymorphism (SNP) rs174537, to metabolize 18-carbon omega-6 (n-6) PUFAs in borage oil (BO) and soybean oil (SO) to GLA, DGLA, and ARA. Methods Healthy adults (n = 64) participated in a randomized, double-blind, crossover intervention. Individuals received encapsulated BO (Borago officinalis L.; 37% LA and 23% GLA) or SO [Glycine max (L.) Merr.; 50% LA and 0% GLA] for 4 wk, followed by an 8-wk washout period, before consuming the opposite oil for 4 wk. Serum lipids and markers of inflammation (C-reactive protein) were assessed for both oil types at baseline and during weeks 2 and 4 of the intervention. Results SO supplementation failed to alter circulating concentrations of any n-6 long-chain PUFAs. In contrast, a modest daily dose of BO elevated serum concentrations of GLA and DGLA in an rs174537 genotype–dependent manner. In particular, DGLA increased by 57% (95% CI: 0.38, 0.79) in GG genotype individuals, but by 141% (95% CI: 1.03, 2.85) in TT individuals. For ARA, baseline concentrations varied substantially by genotype and increased modestly with BO supplementation, suggesting a key role for FADS variation in the balance of DGLA and ARA. Conclusions The results of this study clearly suggest that personalized and population-based approaches considering FADS genetic variation may be necessary to optimize the design of future clinical studies with GLA-containing oils. This trial was registered at clinicaltrials.gov as NCT02337231.

Ceruloplasmin serum concentrations in a randomized population sample of 2,445 subjects

2011 ◽  
Vol 26 (S2) ◽  
pp. 1708-1708 ◽  
Author(s):  
M. Gedack ◽  
C. Schönfeldt-Lecuona ◽  
W. Kratzer ◽  
J. Kassubek ◽  
B. Connemann
Keyword(s):  
Serum Concentration ◽  
Population Sample ◽  
Elevated Serum ◽  
Menkes Disease ◽  
Small Samples ◽  
Immunological Methods ◽  
Normative Values ◽  
Serum Concentrations ◽  
Serum Ceruloplasmin ◽  
Markers Of Inflammation

The metalloprotein ceruloplasmin has been of interest to psychiatrists for decades following early observations of elevated serum copper, and oxidase activity, in patients with schizophrenia. While immunological methods did not confirm elevated serum ceruloplasmin concentrations in schizophrenia, low serum concentrations of ceruloplasmin are typical of Wilson's disease, Menkes’ disease, and aceruloplasminemia making low ceruloplasmin an important marker of disease. Unfortunately, available normative values are of limited usefulness, the majority being derived from oxidase studies; very few immunoturbidimetric or nephelometric studies were performed on small samples, or did not account for known influencing factors. Therefore, the present study was planned to determine nephelometric ceruloplasmin serum concentrations in a large randomized population sample. 2,445 subjects between 12 and 65 years of age were randomly selected from a southern German town of 22,000 inhabitants. The mean ceruloplasmin serum concentration was 331 ± 104 mg/l. Ceruloplasmin serum concentration significantly correlated with gender and age and was higher by 23 mg/l on average in women than in men. There also were significant correlations with lipoprotein concentrations, but not with several other liver-associated features, parameters of metabolism, or markers of inflammation.

Cholesterol-induced Thrombogenicity of the Vessel Wall: Inhibitory Effect of Fluvastatin

2002 ◽  
Vol 87 (04) ◽  
pp. 748-755 ◽  
Author(s):  
Marina Camera ◽  
Vincenzo Toschi ◽  
Carmen Comparato ◽  
Roberta Baetta ◽  
Francesca Rossi ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Transcriptional Activation ◽  
Vessel Wall ◽  
Arterial Wall ◽  
Thrombus Formation ◽  
Plasma Cholesterol ◽  
Elevated Serum ◽  
Rabbit Model ◽  
Cholesterol Levels ◽  
Platelet Deposition

SummaryHigh cholesterol levels are a known risk factor for coronary events. The molecular links between high serum cholesterol and the increased thrombogenicity of the arterial wall are still matter of investigation. In the present study we investigate the relationship between plasma cholesterol, thrombus formation and TF expression in a atherosclerotic rabbit model.Hypercholesterolemic rabbits showed a pronounced TF staining as well as NF-κB activation in the aortic arch. A consistent vessel wall platelet deposition was also observed. Treatment with fluvastatin reduced lipid accumulation, TF overexpression (-60%), NF-κB activation, and platelet deposition (-56%). In vitro studies showed that the drug upregulated IκBa in unstimulated as well as in TNFa-stimulated cells and also impaired the TNF-α-induced Cdc42 prenylation, indicating that fluvastatin interferes with the transcriptional activation of TF gene.These results indicate that the prothrombotic phenotype of arterial wall, associated with elevated serum cholesterol levels, is mediated by TF overexpression. Fluvastatin treatment reduces the prothrombotic tendency by inhibiting TF synthesis.

O2.02: Serum markers of inflammation and abnormalities of the HPA axis are not associated with poor outcome in delirium

2014 ◽  
Vol 5 ◽  
pp. S55
Author(s):  
T.A. Jackson ◽  
B. Sheehan ◽  
A.M. Maclullich ◽  
J.R. Gladman ◽  
J.M. Lord
Keyword(s):  
Hpa Axis ◽  
Serum Markers ◽  
Poor Outcome ◽  
Markers Of Inflammation

The prognostic value of serum IL-6 and YKL-40 in colorectal cancer patients before liver resection.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15078-e15078
Author(s):  
Mathias Holsey Gramkow ◽  
Reetta Peltonen ◽  
Christian Dehlendorff ◽  
Pia J. Osterlund ◽  
Julia S. Johansen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Multivariate Analysis ◽  
Liver Resection ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Elevated Serum ◽  
Disease Free Survival ◽  
Markers Of Inflammation ◽  
Preoperative Serum ◽  
Serum Cea

e15078 Background: IL-6 and YKL-40, markers of inflammation and cancer growth, are high in serum in patients with colorectal cancer (CRC) and associated with shorter overall survival (OS). We hypothesized that preoperative serum IL-6, YKL-40 and CEA are associated with disease free survival (DFS) and OS in patients with metastatic (mCRC) treated with liver resection. Methods: 457 patients (male/female: 267 (58%)/190 (42%), median age 65 [IQR: 58-71]) diagnosed with mCRC who underwent liver resection were included between March 1998 and February 2013. Preoperative serum samples were collected and stored at -80°C until analysis. Serum IL-6 (R&D Systems, UK) and YKL-40 (Quidel, USA) were determined by ELISA. For DFS and OS we estimated crude and adjusted hazard ratios (HR) and corresponding 95% confidence intervals (CIs) with Cox regression for each biomarker separately. The biomarkers were included as log2-transformed continuous variables and adjustment included mutual adjustment between the biomarkers in addition to adjusting for sex and age. Results: The median (IQR) preoperative biomarker levels were: IL-6 (3.5 pg/ml, 2.1-6.1), YKL-40 (75 ng/ml, 48-127) and CEA (5.2 kU/L, 2.6-18.8). Univariate analysis showed that high serum IL-6 and YKL-40 were associated with shorter DFS (IL-6: HR = 1.18, 1.06-1.31, p < 0.01; YKL-40: HR = 1.19, 1.08-1.32, p < 0.01). Serum CEA was not (p = 0.80). Multivariate analysis (all biomarkers) showed that high IL-6 was associated with shorter DFS (HR = 1.15, 1.02-1.29, p = 0.02), whereas YKL-40 (p = 0.08) and CEA (p = 0.51) were not. Univariate analysis showed that high preoperative serum IL-6 and YKL-40 were associated with shorter OS (IL-6: HR = 1.16, 1.03-1.29, p = 0.01; YKL-40: HR = 1.27, 1.14-1.42, p < 0.01). Serum CEA was not associated with OS (p = 0.16). Multivariate analysis (all biomarkers) showed that high YKL-40 was associated with shorter OS (HR = 1.19, 1.05-1.34, p = 0.01), whereas IL-6 (p = 0.25) and CEA (p = 0.26) were not. Patients with elevated serum levels of all 3 biomarkers had the shortest OS (HR = 2.12; 1.29-3.50, p < 0.01). Conclusions: Serum IL-6 and YKL-40 determined before liver resection may be valuable prognostic biomarkers in patients with metastatic CRC.

Sign in / Sign up

Export Citation Format

Share Document