Protective effect of a novel sigma-1 receptor agonist is associated with reduced endoplasmic reticulum stress in stroke male mice

2018 ◽  
Vol 96 (10) ◽  
pp. 1707-1716 ◽  
Author(s):  
Ryuta Morihara ◽  
Toru Yamashita ◽  
Xia Liu ◽  
Yumiko Nakano ◽  
Yusuke Fukui ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Receptor Agonist ◽  
Male Mice ◽  
Sigma 1 Receptor ◽  
Sigma 1

Pridopidine reduces mutant huntingtin‐induced endoplasmic reticulum stress by modulation of the Sigma‐1 receptor

2021 ◽  
Author(s):  
Marina Shenkman ◽  
Michal Geva ◽  
Noga Gershoni‐Emek ◽  
Michael R. Hayden ◽  
Gerardo Z. Lederkremer
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mutant Huntingtin ◽  
Sigma 1 Receptor ◽  
Sigma 1

scholarly journals Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis

Aging ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 9041-9065
Author(s):  
Lile Jiang ◽  
Jinquan Cui ◽  
Cuilian Zhang ◽  
Juanke Xie ◽  
Shaodi Zhang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Granulosa Cells ◽  
Ovarian Reserve ◽  
Diminished Ovarian Reserve ◽  
Sigma 1 Receptor ◽  
Sigma 1

Testicular Injury Attenuated by Rapamycin Through Induction of Autophagy and Inhibition of Endoplasmic Reticulum Stress in Streptozotocin- Induced Diabetic Rats

2019 ◽  
Vol 19 (5) ◽  
pp. 665-675 ◽  
Author(s):  
Wenjiao Shi ◽  
Zhixin Guo ◽  
Ruixia Yuan
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Er Stress ◽  
B Cell Lymphoma ◽  
Diabetic Rats ◽  
Pathological Changes ◽  
Rapamycin Treatment ◽  
Related Proteins

Background and Objective: This study investigated whether rapamycin has a protective effect on the testis of diabetic rats by regulating autophagy, endoplasmic reticulum stress, and oxidative stress. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups: control, diabetic, and diabetic treated with rapamycin, which received gavage of rapamycin (2mg.kg-1.d-1) after induction of diabetes. Diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ, 65mg.Kg-1). All rats were sacrificed at the termination after 8 weeks of rapamycin treatment. The testicular pathological changes were determined by hematoxylin and eosin staining. The protein or mRNA expression of autophagy-related proteins (Beclin1, microtubule-associated protein light chain 3 (LC3), p62), ER stress marked proteins (CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), caspase-12), oxidative stress-related proteins (p22phox, nuclear factor erythroid2-related factor 2 (Nrf2)) and apoptosis-related proteins (Bax, B cell lymphoma-2 (Bcl-2)) were assayed by western blot or real-time fluorescence quantitative PCR. Results: There were significant pathological changes in the testes of diabetic rats. The expression of Beclin1, LC3, Nrf2, Bcl-2 were significantly decreased and p62, CHOP, caspase12, p22phox, and Bax were notably increased in the testis of diabetic rats (P <0.05). However, rapamycin treatment for 8 weeks significantly reversed the above changes in the testis of diabetic rats (P <0.05). Conclusion: Rapamycin appears to produce a protective effect on the testes of diabetic rats by inducing the expression of autophagy and inhibiting the expression of ER-stress, oxidative stress, and apoptosis.

scholarly journals Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

Contact ◽  
2021 ◽  
Vol 4 ◽  
pp. 251525642110265
Author(s):  
Vladimir Zhemkov ◽  
Jen Liou ◽  
Ilya Bezprozvanny
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Composition ◽  
Sigma 1 Receptor ◽  
Functional Roles ◽  
Membrane Contact Sites ◽  
Contact Sites ◽  
Sigma 1 ◽  
Membrane Contact ◽  
Organelle Communication ◽  
Cellular Organelles

Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains.

scholarly journals Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503

2014 ◽  
Vol 134 (6) ◽  
pp. 707-713 ◽  
Author(s):  
Kohga Hirano ◽  
Hideaki Tagashira ◽  
Kohji Fukunaga
Keyword(s):  
Receptor Agonist ◽  
Cardioprotective Effect ◽  
Sigma 1 Receptor ◽  
Sigma 1

Sigma-1 receptor agonist fluvoxamine for delirium in older adults

2011 ◽  
Vol 27 (9) ◽  
pp. 981-983 ◽  
Author(s):  
Kenji Hashimoto ◽  
Tsutomu Furuse
Keyword(s):  
Older Adults ◽  
Receptor Agonist ◽  
Sigma 1 Receptor ◽  
Sigma 1
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