Influence of a Low‐Carbohydrate High‐Fat Diet on Peritoneal Inflammation, Cancer‐Associated Lymphocytes, and Survival in a Murine Carcinomatous Peritonitis Model

Author(s):  
Ayako Watkins ◽  
Kazuhiko Fukatsu ◽  
Kazuya Higashizono ◽  
Tomoki Watanabe ◽  
Midori Noguchi ◽  
...  
2017 ◽  
Vol 42 (11) ◽  
pp. 1158-1164 ◽  
Author(s):  
Caryn Zinn ◽  
Julia McPhee ◽  
Nigel Harris ◽  
Micalla Williden ◽  
Kate Prendergast ◽  
...  

Overweight, obesity, and poor health is becoming a global concern for defence force personnel. Conventional nutrition guidelines are being questioned for their efficacy in achieving optimal body composition and long-term health. This study compared the effects of a 12-week low-carbohydrate, high-fat diet with a conventional, high-carbohydrate, low-fat diet on weight reduction and metabolic health outcomes in at-risk New Zealand Defence Force personnel. In this randomised controlled trial, 41 overweight personnel were assigned to intervention and control groups. Weight, waist circumference, fasting lipids, and glycaemic control were assessed at baseline and at 12 weeks. Within-group change scores were analysed using the t statistic and interpreted using a p < 0.05 level of statistical significance. Between-group mean differences and confidence intervals were analysed using effect sizes and magnitude-based inferences. Twenty-six participants completed the trial (14 intervention, 12 control). Both groups showed statistically significant weight and waist circumference reductions; the intervention group significantly reduced triglycerides and serum glucose and significantly increased high-density lipoprotein cholesterol (HDLc). Relative to control, the intervention group showed small, possibly to likely beneficial effects for weight, triglycerides, glucose, insulin, and homeostasis model assessment of insulin resistance; moderate, likely beneficial effects for HDL cholesterol, triglyceride:HDLc ratio and HbA1c; and a small, likely harmful effect for low-density lipoprotein cholesterol. This dietary approach shows promise for short-term weight loss and improved metabolic health outcomes conditions compared with mainstream recommendations. It should be offered to defence force personnel at least as a viable alternative means to manage their weight and health.


2004 ◽  
Vol 89 (12) ◽  
pp. 6193-6197 ◽  
Author(s):  
Gideon Allick ◽  
Peter H. Bisschop ◽  
Mariette T. Ackermans ◽  
Erik Endert ◽  
Alfred J. Meijer ◽  
...  

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Haruka Yanagisawa ◽  
Haruhiro Toko ◽  
Mutsuo Harada ◽  
Jiaxi Guo ◽  
Satoshi Bujo ◽  
...  

Author(s):  
Gerrit J Breukelman ◽  
Albertus K Basson ◽  
Trayana G Djarova ◽  
Cornelia J Du Preez ◽  
Ina Shaw ◽  
...  

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Saba Marzban ◽  
Mohamed Arbee ◽  
Naseema Vorajee ◽  
Guy A Richards

ABSTRACT A 31-year old non-diabetic woman presented to our hospital with symptoms of dehydration, drowsiness, fatigue, shortness of breath and vomiting present for two consecutive days prior to admission. She had started a low carbohydrate, high fat (LCHF) diet to induce weight loss while breastfeeding her 4-month-old child 2 weeks prior to admission. The patient was found to have a severely high anion gap metabolic acidosis. It was determined to be due to ketoacidosis, which was as a result of carbohydrate restriction in the presence of increased metabolic demands related with the synthesis and secretion of milk. She denied alcohol use or ingestion of any drugs prior to admission. The patient underwent dialysis and received insulin, 5% dextrose water alongside a well-balanced diet with adequate calories. All abnormal laboratory results normalized and follow-up visits were done. Lactating women are at risk of developing ketoacidosis due to high metabolic demands of the body to produce milk. LCHF diets may exacerbate the body’s demand to meet its milk production requirement and result in ketoacidosis. Health professionals need to be aware of the complications of LCHF diet in this population to prevent mortality associated with this condition.


2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hunter S. Waldman ◽  
Alexander J. Heatherly ◽  
Lauren G. Killen ◽  
Angela Hollingsworth ◽  
Yunsuk Koh ◽  
...  

2014 ◽  
Vol 26 (2) ◽  
pp. 58-65 ◽  
Author(s):  
Jordi Merino ◽  
Richard Kones ◽  
Raimon Ferré ◽  
Núria Plana ◽  
Josefa Girona ◽  
...  

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