A systematic review of diagnostic procedures to detect midgut neuroendocrine tumors

2010 ◽  
Vol 102 (7) ◽  
pp. 877-888 ◽  
Author(s):  
Marco Scarpa ◽  
Daniela Prando ◽  
Anna Pozza ◽  
Elisa Degli Esposti ◽  
Carlo Castoro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Diagnostic Procedures

Proteomics of Pancreatic Neuroendocrine Tumors: A Systematic Review

2020 ◽  
Vol 27 (12) ◽  
pp. 1276-1287
Author(s):  
Brigida Anna Maiorano ◽  
Giovanni Schinzari ◽  
Sabrina Chiloiro ◽  
Felicia Visconti ◽  
Domenico Milardi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Prognostic Markers ◽  
State Of The Art ◽  
Therapeutic Targets ◽  
The State ◽  
Pancreatic Neuroendocrine Tumors ◽  
Rare Tumors ◽  
Personalized Approach ◽  
Future Management

Pancreatic neuroendocrine tumors (PanNETs) are rare tumors having usually an indolent behavior, but sometimes with unpredictable aggressiveness. PanNETs are more often non-functioning (NF), unable to produce functioning hormones, while 10-30% present as functioning (F) - PanNETs, such as insulinomas , gastrinomas , and other rare tumors. Diagnostic and prognostic markers, but also new therapeutic targets, are still lacking. Proteomics techniques represent therefore promising approaches for the future management of PanNETs. We conducted a systematic review to summarize the state of the art of proteomics in PanNETs. A total of 9 studies were included, focusing both on NF- and F-PanNETs. Indeed, proteomics is useful for the diagnosis, the prognosis and the detection of therapeutic targets. However, further studies are required. It is also warranted to standardize the analysis methods and the collection techniques, in order to validate proteins with a relevance in the personalized approach to PanNETs management.

scholarly journals Should surgery be conducted for small nonfunctioning pancreatic neuroendocrine tumors: a systematic review

Oncotarget ◽  
2017 ◽  
Vol 8 (21) ◽  
pp. 35368-35375 ◽  
Author(s):  
Jingfei Guo ◽  
Jianjun Zhao ◽  
Xinyu Bi ◽  
Zhiyu Li ◽  
Zhen Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Pancreatic Neuroendocrine Tumors

scholarly journals Medial Tibial Stress Syndrome in Novice and Recreational Runners: A Systematic Review

2020 ◽  
Vol 17 (20) ◽  
pp. 7457
Author(s):  
Claudia Menéndez ◽  
Lucía Batalla ◽  
Alba Prieto ◽  
Miguel Ángel Rodríguez ◽  
Irene Crespo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Frontal Plane ◽  
Diagnostic Procedures ◽  
Medial Tibial Stress Syndrome ◽  
Foot Pressure ◽  
Shockwave Therapy ◽  
Stress Syndrome ◽  
Recreational Runners ◽  
Treatment Procedures

This systematic review evaluates the existing literature about medial tibial stress syndrome (MTSS) in novice and recreational runners. PubMed/MEDLINE, EMBASE, Web of Science, Scopus, SPORTDiscus and CINAHL databases were searched until July 2020. Studies covering risk factors, diagnostic procedures, treatment methods and time to recovery of MTSS in novice and recreational runners were selected. Eleven studies met the inclusion criteria and were included. The risk factors of MTSS are mainly intrinsic and include higher pelvic tilt in the frontal plane, peak internal rotation of the hip, navicular drop and foot pronation, among others. Computed tomography (CT) and pressure algometry may be valid instruments to corroborate the presence of this injury and confirm the diagnosis. Regarding treatment procedures, arch-support foot orthoses are able to increase contact time, normalize foot pressure distribution and similarly to shockwave therapy, reduce pain. However, it is important to take into account the biases and poor methodological quality of the included studies, more research is needed to confirm these results.

scholarly journals Biomarkers for Liquid Biopsies of Pituitary Neuroendocrine Tumors

Biomedicines ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 148
Author(s):  
Wilhelm Gossing ◽  
Marcus Frohme ◽  
Lars Radke
Keyword(s):  
Neuroendocrine Tumors ◽  
Diagnostic Procedures ◽  
Epigenetic Changes ◽  
Early Screening ◽  
Liquid Biopsies ◽  
Marker Substances ◽  
Pile Up ◽  
Screening Efficiency ◽  
Key Nodes ◽  
Tumor Profiling

Pituitary neuroendocrine tumors (PitNET) do not only belong to the most common intracranial neoplasms but seem to be generally more common than has been thought. Minimally invasive liquid biopsies have the potential to improve their early screening efficiency as well as monitor prognosis by facilitating the diagnostic procedures. This review aims to assess the potential of using liquid biopsies of different kinds of biomarker species that have only been obtained from solid pituitary tissues so far. Numerous molecules have been associated with the development of a PitNET, suggesting that it often develops from the cumulative effects of many smaller genetic or epigenetic changes. These minor changes eventually pile up to switch critical molecules into tumor-promoting states, which may be the key regulatory nodes representing the most potent marker substances for a diagnostic test. Drugs targeting these nodes may be superior for the therapeutic outcome and therefore the identification of such pituitary-specific cellular key nodes will help to accelerate their application in medicine. The ongoing genetic degeneration in pituitary adenomas suggests that repeated tumor profiling via liquid biopsies will be necessary for personalized and effective treatment solutions.

Is Resection of Primary Midgut Neuroendocrine Tumors in Patients with Unresectable Metastatic Liver Disease Justified? A Systematic Review and Meta-Analysis

2019 ◽  
Vol 23 (5) ◽  
pp. 1044-1054 ◽  
Author(s):  
Diamantis I. Tsilimigras ◽  
Ioannis Ntanasis-Stathopoulos ◽  
Ioannis D. Kostakis ◽  
Demetrios Moris ◽  
Dimitrios Schizas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Neuroendocrine Tumors ◽  
Meta Analysis ◽  
Metastatic Liver

scholarly journals Pancreatic neuroendocrine tumors and intraductal papillary mucinous neoplasm of the pancreas: a systematic review

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S562
Author(s):  
R. Latorre Fragua ◽  
A. Manuel Vazquez ◽  
C. Ramiro Pérez ◽  
C. Garcia Amador ◽  
B. Gonzalez Sierra ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumors ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Pancreatic Neuroendocrine Tumors ◽  
Mucinous Neoplasm

scholarly journals Economics of gastroenteropancreatic neuroendocrine tumors: a systematic review

2019 ◽  
Vol 10 ◽  
pp. 204201881982821 ◽  
Author(s):  
Enrique Grande ◽  
Ángel Díaz ◽  
Carlos López ◽  
Javier Munarriz ◽  
Juan-José Reina ◽  
...  
Keyword(s):  
Systematic Review ◽  
Economic Evaluation ◽  
Cost Effectiveness ◽  
Adverse Events ◽  
Resource Utilization ◽  
Neuroendocrine Tumors ◽  
Cost Of Illness ◽  
Budget Impact ◽  
The United States ◽  
Economic Evaluations

Background: Despite current interest, enthusiasm and progress in the development of therapies for gastroenteropancreatic (GEP) neuroendocrine tumors (NETs), there are substantial gaps in the published literature regarding cost-of-illness analyses, economic evaluation and budget impact analyses. Compounding the issue is that data on resource utilization and cost-effectiveness of different diagnostic and therapeutic modalities for GEP-NETs are scarce. Methods: A systematic review on the economic impact of GEP-NETs was carried out using four databases: EMBASE, PubMed, the National Health Service Economic Evaluation Database and Cochrane review. Fully published articles from January 2000 to May 2017, in English and Spanish, were included. All articles that satisfied the inclusion criteria were included in the systematic review; summary descriptive statistics were used to describe the methodological characteristics. Results: The 14 studies selected included cost-of-illness analyses ( n = 4), economic evaluations ( n = 7) and budget impact analyses ( n = 3). Almost all studies were performed in the United States. Healthcare costs for patients with NETs included medication, outpatient visits, hospitalizations, and check-ups/tests. Reducing adverse events is an area where cost savings could be achieved; however, there was not enough evidence on the cost impact of adverse events. Conclusion: There is a lack of data related to resource utilization in the field of GEP-NETs. Therefore, cost-effectiveness and budget impact studies of existing and emerging treatments are urgently needed to help the decision-making process for patients with NETs.

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