scholarly journals Topical administration of hydroethanolic extract of Lawsonia inermis (henna) accelerates excisional wound healing process by reducing tissue inflammation and amplifying glucose uptake

2019 ◽  
Vol 35 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Amin Daemi ◽  
Mohammad R. Farahpour ◽  
Ahmad Oryan ◽  
Sirvan Karimzadeh ◽  
Ehsan Tajer
Keyword(s):  
Wound Healing ◽  
Glucose Uptake ◽  
Healing Process ◽  
Topical Administration ◽  
Wound Healing Process ◽  
Lawsonia Inermis ◽  
Tissue Inflammation ◽  
Excisional Wound ◽  
Hydroethanolic Extract

scholarly journals Systemic and topical administration of spermidine accelerates skin wound healing

2020 ◽  
Author(s):  
Daisuke Ito ◽  
Hiroyasu Ito ◽  
Takayasu Ideta ◽  
Ayumu Kanbe ◽  
Soranobu Ninomiya ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Wound Repair ◽  
Healing Process ◽  
Topical Administration ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Skin Wound Healing

Abstract Background The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type plasminogen activator (uPA)/uPA receptor (uPAR) signaling in vitro. Here, we investigated whether the systemic and topical administration of SPD would accelerate the skin wound-repair process in vivo.Methods A skin wound repair model was established using C57BL/6 J mice. SPD was mixed with white petrolatum for topical administration. For systemic administration, SPD mixed with drinking water was orally administered. Changes in wound size over time were calculated using digital photography.Results Systemic and topical SPD treatment significantly accelerated skin wound healing. The administration of SPD promoted the uPA/uPAR pathway in wound sites. Moreover, topical treatment with SPD enhanced the expression of IL-6 and TNF-α in wound sites. Scratch and cell proliferation assays revealed that SPD administration accelerated scratch wound closure and cell proliferation in vitro.Conclusion These results indicate that treatment with SPD promotes skin wound healing through activation of the uPA/uPAR pathway and induction of the inflammatory response in wound sites. The administration of SPD might contribute to new effective treatments to accelerate skin wound healing.

scholarly journals Diabetic Wound Care: A Concise Review of Diabetic Wound and Skincare Ingredients

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Mohammad Afsahi ◽  
Hamid Reza Ahmadi Ashtiani ◽  
Amir Hosein Askari Pour ◽  
Ebrahim Hazrati
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Topical Administration ◽  
The Body ◽  
Wound Healing Process ◽  
Diabetic Wound ◽  
Normal Wound Healing ◽  
Healing Wounds ◽  
Diabetic Wounds

: Chronic wound healing remains a complicated issue in the world's scientific health society. Alterations in the human body conditions such as biochemical, immunological, and physiological states may lead to non-healing wounds, making the treatment an insurmountably long and expensive procedure. Diabetes mellitus disposes the body to many complicated conditions while preventing diabetic wounds away from the normal wound-healing process. As topical administration is a favorable route of treating wounds, here, in this article, different topical materials and their roles are briefly reviewed.

scholarly journals Wound Healing Properties of Ethanolic Extract of Acrostichum aureum and Acrostichum speciosum Rhizome in Rats

2013 ◽  
Vol 1 (2) ◽  
pp. 42-48
Author(s):  
Hendy Putra Herman ◽  
Deny Susanti ◽  
Shahbudin Saad ◽  
Muhammad Taher ◽  
Norazsida Ramli
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Wound Contraction ◽  
Wound Healing Process ◽  
Beneficial Effects ◽  
Biopsy Punch ◽  
Excisional Wound ◽  
Negative Controls

This paper presents the assessment of wound healing properties of ethanolic extract of Acrostichum aureum and A. speciosum in rats. It was carried out on 6 treated groups with 6 rats each group. The excisional wound was made on the dorsal interscapular region of each rat by a 6 mm biopsy punch. T1 and T2 were treated with 5% and 10% A. aureum ethanolic extract in aqua cream, respectively. Meanwhile, T3 and T4 were treated with 5% and 10% A. speciosum ethanolic extract in aqua cream, respectively. Solcoseryl jelly and aqua cream were used as positive and negative controls. The treatments were applied topically twice daily, wound contraction and period of epithelization were measured every 2 days. The results showed that wound treated with 10% A. speciosum (T4) exerted faster wound contraction significantly (p < 0.05) compared to the negative control. It was also enhanced epithelization period (9.33 ± 3.20 days) of the wounds significantly (p < 0.05). In conclusion, these results strongly suggested the beneficial effects of both plant extracts for enhancing wound healing process.

scholarly journals The effects of topical liposomal resveratrol on incisional and excisional wound healing process

TURKDERM ◽  
2019 ◽  
Vol 53 (4) ◽  
pp. 128-134
Author(s):  
Mehmet Yalçın Günal ◽  
Şule Ayla ◽  
Nejda Bedri ◽  
Mustafa Çağlar Beker ◽  
Ahmet Burak Çağlayan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Wound Healing Process ◽  
Excisional Wound

scholarly journals The Protective Effect of Snail Secretion Filtrate in an Experimental Model of Excisional Wounds in Mice

2021 ◽  
Vol 8 (8) ◽  
pp. 167
Author(s):  
Enrico Gugliandolo ◽  
Francesco Macrì ◽  
Roberta Fusco ◽  
Rosalba Siracusa ◽  
Ramona D’Amico ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Biological Properties ◽  
Helix Aspersa ◽  
Wound Healing Process ◽  
Vascular Endothelial ◽  
Wound Model ◽  
Tnf Α ◽  
Excisional Wound ◽  
Endothelial Growth Factor

Wound healing is a physiological process comprising several coordinated phases, such as inflammation, proliferation, and remodeling. For centuries, Helix aspersa Muller mucus has been known to have biological properties that are useful for treating skin disorders. In this study, we used a full-thickness excisional wound model in mice to test the hypothesis that Snail Secretion Filtrate (SSF) can improve the wound healing process. The mucus from Helix aspersa Muller was obtained mechanically by manually stimulating snails with a sterile cotton swab tip, and then the mucus was subjected to a series of filtrations to obtain SSF. After wounding, the mice were treated topically with SSF for 14 days. Our macroscopic results show that the SSF treatment significantly improved the speed and percentage of wound area closure. Furthermore, SSF improved several markers of proper wound healing, such as collagen deposition (Masson, COL3A1, matrix metalloproteinases (MMPs)) and the tissue remodeling process (α-sma, vascular-endothelial growth factor (VEGF)). SSF was also able to counteract the inflammatory process in injured wound tissue (myeloperoxidase (MPO) IL-1β, IL-6, TNF-α). In conclusion, our results show that SSF is able to enhance the speed and efficiency of wound healing and positively regulate several aspects of the wound healing process, such as the proliferative and remodeling phases.

scholarly journals Systemic and topical administration of spermidine accelerates skin wound healing

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Daisuke Ito ◽  
Hiroyasu Ito ◽  
Takayasu Ideta ◽  
Ayumu Kanbe ◽  
Soranobu Ninomiya ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Wound Repair ◽  
Healing Process ◽  
Topical Administration ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Skin Wound Healing

Abstract Background The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type plasminogen activator (uPA)/uPA receptor (uPAR) signaling in vitro. Here, we investigated whether the systemic and topical administration of SPD would accelerate the skin wound-repair process in vivo. Methods A skin wound repair model was established using C57BL/6 J mice. SPD was mixed with white petrolatum for topical administration. For systemic administration, SPD mixed with drinking water was orally administered. Changes in wound size over time were calculated using digital photography. Results Systemic and topical SPD treatment significantly accelerated skin wound healing. The administration of SPD promoted the uPA/uPAR pathway in wound sites. Moreover, topical treatment with SPD enhanced the expression of IL-6 and TNF-α in wound sites. Scratch and cell proliferation assays revealed that SPD administration accelerated scratch wound closure and cell proliferation in vitro. Conclusion These results indicate that treatment with SPD promotes skin wound healing through activation of the uPA/uPAR pathway and induction of the inflammatory response in wound sites. The administration of SPD might contribute to new effective treatments to accelerate skin wound healing.

scholarly journals Effect of Patah Tulang Latex (Euphorbia tirucalli L.) on Wound Healing in Wistar Rat

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Galuh Ratnawati ◽  
Kurniasih - Kurniasih ◽  
Surya Amanu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Topical Administration ◽  
Wistar Rat ◽  
Control Group ◽  
Wound Healing Process ◽  
Cellular Reaction ◽  
Skin Wound Healing ◽  
Euphorbia Tirucalli ◽  
Cd4 Lymphocyte

Injure healing process occured on four phases such as hemostatis, inflammation, and maturation. Latex of Patah Tulang (Euphorbia tirucalli L.) can heal the wound because of its component active. Aim of this research was to find out the effect of ointment topical of E. tirucalli L. to wound healing process based on macroscopic and microscopic examination and cellular reaction of CD4+ lymphocyte. Male Wistar Rat, 2 month old, 150-200 Gram of body weight, as much as 36 rats. Rats were divided into 4 groups, and were anesthesized before punctioned on the 2 sides of lateral vertebrae. Group one was used as a control, group two was given with the ointment 9% of E. tirucalli L., group three was given with 23% of E. tirucalli L., and group four was given madecassol®. Treatment was given once a day for 15 days. Macroscopical and microscopical changes were observed at the fifth, tenth, and fifteenth day. Macroscopical observation was the diameter of injure. Microscopical observation consisted of epidermal thicness, number of fibroblast, using Haematoxylin and Eosin staining, and cellular reaction of CD4+ lymphocyte using imunohistochemistry. The results showed that topical administration of E. tirucalli ointment 9% and 23% potential to accelerate wistar skin wound healing puncture wounds. There was no difference between E. tirucalli ointment 9% and 23% application to observed parameters.Keywords: Euphorbia tirucalli L., injure healing, macroscopic, microscopic, lymphocyte CD4+

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Sign in / Sign up

Export Citation Format

Share Document