Eugenol modulates genomic methylation and inactivates breast cancer‐associated fibroblasts through E2F1‐dependent downregulation of DNMT1/DNMT3A

2021 ◽  
Author(s):  
Layla A. Al‐Kharashi ◽  
Tala Bakheet ◽  
Wejdan A. AlHarbi ◽  
Nisreen Al‐Moghrabi ◽  
Abdelilah Aboussekhra
Keyword(s):  
Breast Cancer ◽  
Cancer Associated Fibroblasts ◽  
Genomic Methylation

scholarly journals CD63 + Cancer‐Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR‐22

2020 ◽  
Vol 7 (21) ◽  
pp. 2002518
Author(s):  
Yuan Gao ◽  
Xiaoju Li ◽  
Cheng Zeng ◽  
Chenlin Liu ◽  
Qiang Hao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tamoxifen Resistance ◽  
Cancer Associated Fibroblasts

Relationship between MRI findings and invasive breast cancer with podoplanin-positive cancer-associated fibroblasts

Breast Cancer ◽  
2021 ◽  
Author(s):  
Ken Yamaguchi ◽  
Yukiko Hara ◽  
Isao Kitano ◽  
Takahiro Hamamoto ◽  
Kazumitsu Kiyomatsu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Cancer Associated Fibroblasts ◽  
Mri Findings

scholarly journals Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblasts

2015 ◽  
Vol 112 (10) ◽  
pp. 1675-1686 ◽  
Author(s):  
C Angelucci ◽  
G Maulucci ◽  
A Colabianchi ◽  
F Iacopino ◽  
A D'Alessio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration ◽  
Stearoyl Coa Desaturase

scholarly journals Cancer-Associated Fibroblasts in Breast Cancer Treatment Response and Metastasis

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3146
Author(s):  
Patricia Fernández-Nogueira ◽  
Gemma Fuster ◽  
Álvaro Gutierrez-Uzquiza ◽  
Pere Gascón ◽  
Neus Carbó ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptors ◽  
Treatment Strategies ◽  
Specific Treatment ◽  
Growth Factor Receptor ◽  
Cancer Associated Fibroblasts ◽  
Luminal A ◽  
Luminal B ◽  
Number Of Patients ◽  
Current Therapies

Breast cancer (BrCa) is the leading cause of death among women worldwide, with about one million new cases diagnosed each year. In spite of the improvements in diagnosis, early detection and treatment, there is still a high incidence of mortality and failure to respond to current therapies. With the use of several well-established biomarkers, such as hormone receptors and human epidermal growth factor receptor-2 (HER2), as well as genetic analysis, BrCa patients can be categorized into multiple subgroups: Luminal A, Luminal B, HER2-enriched, and Basal-like, with specific treatment strategies. Although chemotherapy and targeted therapies have greatly improved the survival of patients with BrCa, there is still a large number of patients who relapse or who fail to respond. The role of the tumor microenvironment in BrCa progression is becoming increasingly understood. Cancer-associated fibroblasts (CAFs) are the principal population of stromal cells in breast tumors. In this review, we discuss the current understanding of CAFs’ role in altering the tumor response to therapeutic agents as well as in fostering metastasis in BrCa. In addition, we also review the available CAFs-directed molecular therapies and their potential implications for BrCa management.

Abstract 2513: Convergence of cancer associated fibroblasts (CAFs) and progesterone receptor (PR) signaling in ER+ luminal breast cancer

2021 ◽  
Author(s):  
Angela Spartz ◽  
Caroline Diep ◽  
Benjamin Troness ◽  
Carol A. Lange ◽  
Dorraya El-Ashry
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Luminal Breast Cancer ◽  
Cancer Associated Fibroblasts

scholarly journals Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer

2018 ◽  
Vol 37 (1) ◽  
Author(s):  
Yuyuan Yao ◽  
Qinglong Guo ◽  
Yue Cao ◽  
Yangmin Qiu ◽  
Renxiang Tan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Associated Fibroblasts ◽  
Artemisinin Derivatives

scholarly journals Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

Oncotarget ◽  
2017 ◽  
Vol 8 (11) ◽  
pp. 17981-17994 ◽  
Author(s):  
Balaji Krishnamachary ◽  
Ioannis Stasinopoulos ◽  
Samata Kakkad ◽  
Marie-France Penet ◽  
Desmond Jacob ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Structure And Function ◽  
Cyclooxygenase 2 ◽  
Cancer Associated Fibroblasts ◽  
Matrix Structure ◽  
And Function
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