scholarly journals Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

Oncotarget ◽  
2017 ◽  
Vol 8 (11) ◽  
pp. 17981-17994 ◽  
Author(s):  
Balaji Krishnamachary ◽  
Ioannis Stasinopoulos ◽  
Samata Kakkad ◽  
Marie-France Penet ◽  
Desmond Jacob ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Structure And Function ◽  
Cyclooxygenase 2 ◽  
Cancer Associated Fibroblasts ◽  
Matrix Structure ◽  
And Function

scholarly journals RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A)

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2689
Author(s):  
Sven Roßwag ◽  
Gitta Thiede ◽  
Jonathan P. Sleeman ◽  
Sonja Thaler
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Forkhead Box ◽  
Cancer Initiation ◽  
And Function

The estrogen receptor alpha (ERα) is expressed by the majority of breast cancers and plays an important role in breast cancer development and tumor outgrowth. Although ERα is well known to be a specific and efficient therapeutic target, the molecular mechanisms that are responsible for the control of ERα expression and function in the context of breast cancer initiation and progression are complex and not completely elucidated. In previous work, we have demonstrated that the tumor suppressor RASSF1A inhibits ERα expression and function in ERα-positive breast cancer cells through an AKT-dependent mechanism. Transcriptional activators such as forkhead box protein M1 (FOXM1) and forkhead transcription factor 3A (FOXO3A) and signaling pathways such as the Hippo pathway are also known to modulate ERα expression and activity. Here we report that RASSF1A acts as an inhibitor of ERα-driven breast cancer cell growth through a complex, hierarchically organized network that initially involves suppression of the Hippo effector Yes-associated protein 1 (YAP1), which is followed by inhibition of AKT1 activity, increased FOXO3A activity as well as a blockade of FOXM1 and ERα expression. Together our findings provide important new mechanistic insights into how the loss of RASSF1A contributes to ERα+ breast cancer initiation and progression.

scholarly journals MT1-MMP–Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function Following Myocardial Infarction

2012 ◽  
Vol 180 (5) ◽  
pp. 1863-1878 ◽  
Author(s):  
Gerald C. Koenig ◽  
R. Grant Rowe ◽  
Sharlene M. Day ◽  
Farideh Sabeh ◽  
Jeffrey J. Atkinson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Extracellular Matrix ◽  
Structure And Function ◽  
Matrix Structure ◽  
And Function

scholarly journals The Effects of 17β-estradiol on Mitochondrial Biogenesis and Function in Breast Cancer Cell Lines are Dependent on the ERα/ERβ Ratio

2012 ◽  
Vol 29 (1-2) ◽  
pp. 261-268 ◽  
Author(s):  
Jorge Sastre-Serra ◽  
Mercedes Nadal-Serrano ◽  
Daniel Gabriel Pons ◽  
Adamo Valle ◽  
Jordi Oliver ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Mitochondrial Biogenesis ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
17Β Estradiol ◽  
And Function

scholarly journals Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line

2003 ◽  
Vol 6 (4) ◽  
pp. 277 ◽  
Author(s):  
Hyuck Song ◽  
Tae Young Koo ◽  
Ji Hoon Park ◽  
Ki Hak Song ◽  
Sung Tae Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Cyclooxygenase 2 ◽  
Cox 2
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