Estimate of the proportion of uncertain diagnoses of pudendal neuralgia in women with chronic pelvic‐perineal pain: A systematic review with a descriptive data synthesis

Abstract Background Understanding the relationships between physical fitness characteristics and sports injury may assist with the development of injury minimisation programs. The purpose of this systematic review was to investigate the association between physical fitness attributes and sports injury in female, team ball sport players. Methods Four scientific databases (MEDLINE, EMBASE, SPORTDiscus, Scopus) and reference lists of relevant research were searched for eligible studies up to September 2, 2019. Full-text articles examining the relationship between physical fitness and sports injury in female, team ball sport players were included. A modified Downs and Black checklist was used to assess methodological quality. Data synthesis determined summary conclusions based on the number of significant relationships divided by the total relationships investigated and reported as a percentage. Level of certainty was identified for summary conclusions based on level of evidence. Sub-analyses regarding competition level, age, and single injury types were also conducted. Results A total of 44 studies were included. Data synthesis revealed no associations (low to moderate certainty) between body composition (1/9; 11%), flexibility (18–20%), and balance (2/8; 25%) and ‘any injury’ classification. No associations (mostly of moderate certainty) were found between flexibility (0–27%), muscular strength (0–27%), and body composition (14–33%) and various body region injury classifications, whereas mixed summary conclusions were shown for balance (0-48%). Many associations between physical fitness and sports injury were deemed ‘unknown’ or with an insufficient level of certainty. Sub-analyses revealed no association between strength and noncontact ACL injuries (0/5; 0%) or ankle sprains (0/12; 0%), and between flexibility and ankle sprains (1/5; 20%); however, insufficient certainty of these results exists. Clear associations were concluded between balance and lower body injuries in female, non-elite (10/16; 63%) and junior (9/12; 75%) team ball sport players, with moderate and insufficient certainty of these results, respectively. Conclusion Limited evidence is available to demonstrate relationships between physical fitness and sports injury in female, team ball sport players. High-quality evidence investigating the multifactorial nature of sports injury, including the interactions physical fitness qualities have with other injury determinants, is needed to better understand the role of physical fitness in minimising sports injuries in female, team ball sport players. Trial Registration CRD42017077374 (PROSPERO on September 14, 2017).

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Prevalence of potential respiratory symptoms in survivors of hospital admission after coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Chronic Respiratory Disease ◽

10.1177/14799731211002240 ◽

2021 ◽

Vol 18 ◽

pp. 147997312110022

Author(s):

Kevin Cares-Marambio ◽

Yessenia Montenegro-Jiménez ◽

Rodrigo Torres-Castro ◽

Roberto Vera-Uribe ◽

Yolanda Torralba ◽

...

Keyword(s):

Systematic Review ◽

Chest Pain ◽

Hospital Admission ◽

Respiratory Symptoms ◽

Meta Analysis ◽

Pooled Analysis ◽

Data Synthesis ◽

Recent Onset ◽

Persistent Symptoms

Knowledge on the sequelae of Coronavirus Disease 2019 (COVID-19) remains limited due to the relatively recent onset of this pathology. However, the literature on other types of coronavirus infections prior to COVID-19 reports that patients may experience persistent symptoms after discharge. To determine the prevalence of respiratory symptoms in survivors of hospital admission after COVID-19 infection. A living systematic review of five databases was performed in order to identify studies which reported the persistence of respiratory symptoms in COVID-19 patients after discharge. Two independent researchers reviewed and analysed the available literature, and then extracted and assessed the quality of those articles. Of the 1,154 reports returned by the initial search nine articles were found, in which 1,816 patients were included in the data synthesis. In the pooled analysis, we found a prevalence of 0.52 (CI 0.38–0.66, p < 0.01, I 2 = 97%), 0.37 (CI 0.28–0.48, p < 0.01, I 2 = 93%), 0.16 (CI 0.10–0.23, p < 0.01, I 2 = 90%) and 0.14 (CI 0.06–0.24, p < 0.01, I 2 = 96%) for fatigue, dyspnoea, chest pain, and cough, respectively. Fatigue, dyspnoea, chest pain, and cough were the most prevalent respiratory symptoms found in 52%, 37%, 16% and 14% of patients between 3 weeks and 3 months, after discharge in survivors of hospital admission by COVID-19, respectively.

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Procedure-specific acute pain trajectory after elective total hip arthroplasty: systematic review and data synthesis

British Journal of Anaesthesia ◽

10.1016/j.bja.2021.02.036 ◽

2021 ◽

Vol 127 (1) ◽

pp. 110-132

Author(s):

Paul Panzenbeck ◽

Arvind von Keudell ◽

Girish P. Joshi ◽

Claire X. Xu ◽

Kamen Vlassakov ◽

...

Keyword(s):

Systematic Review ◽

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Acute Pain ◽

Data Synthesis ◽

Total Hip

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Auditory and Vestibular Functioning in Individuals with Type-2 Diabetes Mellitus: A Systematic Review

International Archives of Otorhinolaryngology ◽

10.1055/s-0041-1726041 ◽

2021 ◽

Author(s):

Prawin Kumar ◽

Niraj Kumar Singh ◽

Kumari Apeksha ◽

Vipin Ghosh ◽

Raveendran Rajesh Kumar ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Auditory System ◽

Microvascular Complications ◽

Data Synthesis ◽

Vestibular Tests ◽

Peripheral Auditory System

Abstract Introduction Diabetes mellitus is a metabolic disease associated with a rise in the level of blood glucose. Individuals with diabetes mellitus are more likely to develop hearing loss, tinnitus, and dizziness due to macro- and microvascular complications. The extent to which auditory and vestibular functions are impaired in individuals with type-2 diabetes mellitus is still under debate. Objective To systematically review studies focusing on auditory and vestibular functions in individuals with type-2 diabetes mellitus. Data Synthesis A search was conducted in the PubMed, MedlinePlus, Ingenta Connect and Google Scholar databases for articles published until June 2019. A total of 15,980 articles were primarily retrieved, 33 of which were shortlisted based on the inclusion criteria set by the investigators for the systematic review. Out of 33 full-length articles, 26 evaluated the functioning of the auditory system, while 7 evaluated the functioning of the vestibular system. Most studies related to auditory functioning reported a significant effect of type-2 diabetes mellitus on the peripheral auditory system, whereas studies on vestibular functioning reported no significant effect of diabetes mellitus on the functioning of the peripheral vestibular end-organ. Conclusion Overall, the results of various audiological and peripheral vestibular tests reveal distinctive peripheral and/or central auditory and vestibular end-organ impairments in individuals with type-2 diabetes mellitus.

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Prioritising recommendations following analyses of adverse events in healthcare: a systematic review

BMJ Open Quality ◽

10.1136/bmjoq-2019-000843 ◽

2020 ◽

Vol 9 (4) ◽

pp. e000843

Author(s):

Kelly Bos ◽

Maarten J van der Laan ◽

Dave A Dongelmans

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Data Extraction ◽

Data Sources ◽

Cochrane Library ◽

High Quality ◽

Data Synthesis ◽

Study Selection ◽

Personal Opinion ◽

User Friendly

PurposeThe purpose of this systematic review was to identify an appropriate method—a user-friendly and validated method—that prioritises recommendations following analyses of adverse events (AEs) based on objective features.Data sourcesThe electronic databases PubMed/MEDLINE, Embase (Ovid), Cochrane Library, PsycINFO (Ovid) and ERIC (Ovid) were searched.Study selectionStudies were considered eligible when reporting on methods to prioritise recommendations.Data extractionTwo teams of reviewers performed the data extraction which was defined prior to this phase.Results of data synthesisEleven methods were identified that are designed to prioritise recommendations. After completing the data extraction, none of the methods met all the predefined criteria. Nine methods were considered user-friendly. One study validated the developed method. Five methods prioritised recommendations based on objective features, not affected by personal opinion or knowledge and expected to be reproducible by different users.ConclusionThere are several methods available to prioritise recommendations following analyses of AEs. All these methods can be used to discuss and select recommendations for implementation. None of the methods is a user-friendly and validated method that prioritises recommendations based on objective features. Although there are possibilities to further improve their features, the ‘Typology of safety functions’ by de Dianous and Fiévez, and the ‘Hierarchy of hazard controls’ by McCaughan have the most potential to select high-quality recommendations as they have only a few clearly defined categories in a well-arranged ordinal sequence.

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Pharmacological management of seizures in patients with COVID-19: a systematic review

AAS Open Research ◽

10.12688/aasopenres.13224.1 ◽

2021 ◽

Vol 4 ◽

pp. 29

Author(s):

Priscilla Kolibea Mante ◽

Nana Ofori Adomako ◽

John-Paul Omuojine ◽

Paulina Antwi

Keyword(s):

Systematic Review ◽

Sodium Valproate ◽

Case Reports ◽

Meta Analysis ◽

Descriptive Data ◽

Pharmacological Management ◽

Drug Choice ◽

Number Of Patients ◽

Clonic Seizures ◽

Antiepileptic Drug Therapy

Background: Some patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported to exhibit neurological symptoms such as seizures and impaired consciousness. Our study reviews reported cases to assess the pharmacological approach to managing seizures in SARS-CoV-2 patients and associated outcomes. Methods: A systematic review of case reports on the incidence of seizures following coronavirus disease 2019 (COVID-19) among patients that reported use of antiepileptic drugs (AEDs) in management was performed by using the PRISMA (preferred reporting items for systematic reviews and meta-analysis) guidelines. Databases used included EMBASE, PubMed, SCOPUS, and Google Scholar. Data was presented as qualitative and descriptive data. Results: In total, 67 articles were selected for full-text assessment, of which 19 were included in the final review. Patients had a median age of 54 years, most of whom were male. Remdisivir, dexamethasone, Laminavir, hydroxychloroquine, azithromycin, and Lopinavir-ritonavir were common agents used in the management of COVID-19. Most patients presented with either generalized tonic-clonic seizures or status epilepticus. Most patients received levetiracetam as drug choice or as part of their regimen. Other AEDs commonly prescribed included midazolam and sodium valproate. Some patients received no antiepileptic drug therapy. Most of the patients who died had more than one comorbidity. Also, most of the patients who died received COVID-19 treatment drugs. None of the patients who received midazolam as drug choice or as part of their regimen developed recurrent seizures in contrast to patients who received levetiracetam and sodium valproate as drug choice or as part of their regimen. Interestingly, none of the patients who received no AEDs suffered recurrent seizures or died. Conclusions: Standard guidelines for managing seizures in COVID-19 patients may be required. A limitation of this review is that it involved the use of case reports with no controls and a small number of patients.

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Diagnostic Test Accuracy of the 4AT for Delirium Detection: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17207515 ◽

2020 ◽

Vol 17 (20) ◽

pp. 7515 ◽

Cited By ~ 1

Author(s):

Eunhye Jeong ◽

Jinkyung Park ◽

Juneyoung Lee

Keyword(s):

Systematic Review ◽

Diagnostic Test ◽

Healthcare Professionals ◽

Meta Analysis ◽

Diagnostic Test Accuracy ◽

Test Accuracy ◽

Summary Receiver Operating Characteristic ◽

Bivariate Model ◽

Data Synthesis

Under-recognition of delirium is an international problem. For the early detection of delirium, a feasible and valid screening tool for healthcare professionals is needed. This study aimed to present a scientific reason for using the 4 ‘A’s Test (4AT) through a systematic review and meta-analysis of studies on the diagnostic test accuracy. We systematically searched articles in the EMBASE, MEDLINE, CINAHL, and PsycINFO databases and selected relevant articles on the basis of the predefined inclusion criteria. The quality of the included articles was evaluated using the Quality Assessment of the Diagnostic Accuracy Studies-2 tool. We estimated the pooled values of diagnostic test accuracy by employing the bivariate model and the hierarchical summary receiver operating characteristic (HSROC) model in data synthesis. A total of 3729 patients of 13 studies were included in the analysis. The pooled estimates of sensitivity and specificity of the 4AT were 81.5% (95% confidence interval: 70.7%, 89.0%) and 87.5% (79.5%, 92.7%), respectively. Given the 4AT’s evidence of accuracy and practicality, we suggest healthcare professionals to utilize this tool for routine screening of delirium. However, for detecting delirium in the dementia population, further work is required to evaluate the 4AT with other cut-off points or scoring methods in order for it to be more sensitive and specific.

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Successful Treatment of Pudendal Neuralgia With Tricolumn Spinal Cord Stimulation

Neurosurgery ◽

10.1227/neu.0b013e318260fd8f ◽

2012 ◽

Vol 71 (3) ◽

pp. E757-E763 ◽

Cited By ~ 14

Author(s):

Philippe Rigoard ◽

Alexandre Delmotte ◽

Alexis Moles ◽

Rémi Hervochon ◽

Thomas Vrignaud ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Stimulation ◽

Therapeutic Option ◽

Treatment Algorithm ◽

Radicular Pain ◽

Conus Medullaris ◽

Decompressive Surgery ◽

Perineal Pain ◽

Pudendal Neuralgia ◽

Scale Scores

Abstract BACKGROUND AND IMPORTANCE: There is large variation in the success of decompressive surgery for pudendal neuralgia (PN), the most chronic, disabling form of perineal pain. We attempt to determine whether spinal cord stimulation using new-generation multicolumn leads could form part of the treatment algorithm for refractory PN. CLINICAL PRESENTATION: A man with PN that was unresponsive to conventional treatment demonstrated a neuropathic component and had a negative response to nerve infiltrations (so he was not indicated for decompressive surgery) and a positive response to perianal transcutaneous electrical nerve stimulation and was implanted with a 16-contact surgical lead at the level of conus medullaris, allowing multicolumn stimulation. Using transverse combinations, it was possible to obtain 100% paresthesia over the perineal area without unwanted dorsal root stimulation. Perineal and radicular pain was successfully relieved for up to 12 months (80% and 60% reduction in the visual analogue scale scores, respectively), with an improvement in all quality of life domains and a reduction in drug consumption. CONCLUSION: Spinal cord stimulation using a 16-contact lead may be a viable therapeutic option for patients with refractory PN for whom decompressive surgery is contraindicated.

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SEVERE PERTUSSIS IN CHILDHOOD: UPDATE AND CONTROVERSY - SYSTEMATIC REVIEW

Revista Paulista de Pediatria ◽

10.1590/1984-0462/;2019;37;3;00006 ◽

2019 ◽

Vol 37 (3) ◽

pp. 351-362

Author(s):

Márcia Borges Machado ◽

Saulo Duarte Passos

Keyword(s):

Systematic Review ◽

Whooping Cough ◽

Age Groups ◽

Severe Form ◽

Therapeutic Options ◽

Electronic Library ◽

Data Synthesis ◽

Control And Prevention ◽

Neonates And Infants

ABSTRACT Objective: Through a systematic review, this essay aimed at revising the concepts of severe pertussis, updating the epidemiology, pathophysiology, clinical presentation, antibiotic therapy and auxiliary therapeutic options for symptomatology and complications. Data sources: This review considered publications from the last 30years in the databases US National Library of Medicine (PubMed), Scientific Electronic Library Online (SciELO), Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Cochrane, Google Scholar, as well as protocols of the Ministry of Health and recommendations of the Centers for Disease Control and Prevention, related to childhood pertussis (whooping cough), with emphasis on its severe form. This research was based on keywords derived from the terms “pertussis”, “azithromycin”, “antitussives”, “leukocyte reduction” in Portuguese and English. Duplicate studies and those with unavailable full-text were excluded. Data synthesis: Among 556 records found, 54 were selected for analysis. Pertussis, as a reemerging disease, has affected all age groups, evidencing the transient immunity conferred by infection and vaccination. Severe cases occur in neonates and infants, with secondary viral and bacterial complications and malignant pertussis, a longside hyperleukocytosis, respiratory failure and shock. Macrolides continue to be the chosen antibiotics, while antitussives for coughing remain without efficacy. The prompt treatment in Intensive Care Units improved the prognostic in severe cases, and transfusion was promising among procedures for leukoreduction. Conclusions: Approaching severe pertussis in childhood remains a challenge for diagnostic and therapy, as the available therapeutic options are still unsatisfactory. Strategies of prevention are expected to reduce the occurrence of severe cases, while new studies should confirm the role of auxiliary therapies.

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B-77 Buddha's Brain: A Systematic Review of Mindfulness-Based Interventions in the Rehabilitation Context

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acz034.160 ◽

2019 ◽

Vol 34 (6) ◽

pp. 1025-1025

Author(s):

C Smart ◽

J Ali ◽

K Silveira ◽

J Viczko

Keyword(s):

Systematic Review ◽

Processing Speed ◽

Mindfulness Meditation ◽

Holistic Approach ◽

Symptom Clusters ◽

Controlled Trials ◽

Data Synthesis ◽

Psychological Variables ◽

Specific Practice ◽

Initial List

Abstract Objective The current study was intended to provide a rigorous systematic review of the evidence to date regarding the efficacy of mindfulness-based interventions (MBIs) in persons with neurologic illness/injury, a form of treatment that may be particularly well suited to the rehabilitation context due to its holistic approach. Data Selection The search was conducted in accordance with the PRISMA guidelines for systematic reviews. We included any controlled trials of MBIs conducted in a neurological population, employing the specific practice of mindfulness meditation. A search protocol was created and executed by three of the authors to promote reliability and obtain the initial list of abstracts (n = 35). Two authors independently reviewed and extracted data from the final 30 full-text articles. Data Synthesis A majority (83%) of studies used randomized designs, with the most frequent diagnoses of interest being aging/ neurodegenerative diseases (n = 10), followed by MS (n = 6), TBI (n = 5), and ADHD (n = 5). Most trials that assessed psychological variables found significant benefits (n = 24), including variables such as fatigue, self-reported cognitive function, and specific neurological symptoms. Comparatively fewer studies looked at cognitive and/or neural outcomes (n = 18) such as attention or processing speed, although most did tend to find significant benefits in these outcomes as well. Conclusions Results of this review indicate promising evidence for the application of MBIs in the rehabilitation context. Further work is needed to determine whether targeting MBIs to certain symptom clusters as opposed to diagnoses would enhance observed clinical benefit.

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