scholarly journals Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women

Obesity ◽  
2014 ◽  
Vol 22 (7) ◽  
pp. 1679-1684 ◽  
Author(s):  
Tongjian You ◽  
Xuewen Wang ◽  
Karin M. Murphy ◽  
Mary F. Lyles ◽  
Jamehl L. Demons ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Cytokine Production ◽  
Obese Women ◽  
Before And After

scholarly journals Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

2008 ◽  
Vol 158 (6) ◽  
pp. 905-910 ◽  
Author(s):  
Isabelle Castan-Laurell ◽  
Michaela Vítkova ◽  
Danièle Daviaud ◽  
Cédric Dray ◽  
Michaela Kováčiková ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Plasma Levels ◽  
Tissue Expression ◽  
Hypocaloric Diet ◽  
Mrna Levels ◽  
Obese Women ◽  
Tnf Α ◽  
Before And After ◽  
Plasma Apelin

ObjectiveApelin is a novel adipokine acting on APJ receptor, regulated by insulin and tumor necrosis factor-α (TNF-α) in adipose tissue (AT). Plasma apelin levels are increased in obese hyperinsulinemic subjects. The aim was to investigate whether the hypocaloric diet associated with weight loss modifies the elevated plasma apelin levels and the expression of apelin and APJ receptor in AT in obese women.Design and methodsFasting plasma levels of apelin and TNF-α as well as mRNA levels of apelin and APJ in AT were measured before and after a 12-week hypocaloric weight-reducing diet in 20 obese women (body mass index (BMI) before diet 32.2±6.4 kg/m2). Twelve healthy women with a BMI of 20.7±0.6 kg/m2 served as reference.ResultsPlasma levels of apelin and TNF-α were higher in obese compared with lean controls. The hypocaloric diet resulted in a significant decrease of BMI to 29.8±6.3 kg/m2, plasma insulin (8.16±0.73 to 6.58±0.66 mU/l), apelin (369±25 pg/ml to 257±12 pg/ml), TNF-α levels (0.66±0.04 pg/ml to 0.56±0.04 pg/ml), and AT mRNAs of apelin and APJ. In addition, changes in AT mRNA apelin were related to changes in AT mRNA APJ levels.ConclusionThe hypocaloric diet associated with weight loss reduces the increased plasma and AT expression of apelin in obese women. This reduced apelin expression in AT could contribute to decreased circulating apelin levels.

scholarly journals Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss*

2000 ◽  
Vol 85 (9) ◽  
pp. 3338-3342 ◽  
Author(s):  
Jean-Philippe Bastard ◽  
Claude Jardel ◽  
Eric Bruckert ◽  
Patricia Blondy ◽  
Jacqueline Capeau ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Interleukin 6 ◽  
Subcutaneous Adipose Tissue ◽  
Obese Women ◽  
Subcutaneous Adipose

scholarly journals An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Miles C Benton ◽  
Alice Johnstone ◽  
David Eccles ◽  
Brennan Harmon ◽  
Mark T Hayes ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Adipose Tissue ◽  
Human Adipose Tissue ◽  
Before And After ◽  
Obesity Genes

Ghrelin and Obestatin Levels in Severely Obese Women Before and After Weight Loss After Roux-en-Y Gastric Bypass Surgery

2008 ◽  
Vol 19 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Christian L. Roth ◽  
Thomas Reinehr ◽  
Gerit-Holger Schernthaner ◽  
Hans-Peter Kopp ◽  
Stefan Kriwanek ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Obese Women ◽  
Before And After ◽  
Severely Obese

Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone

1998 ◽  
Vol 275 (3) ◽  
pp. E507-E515 ◽  
Author(s):  
C. D. Russell ◽  
R. N. Petersen ◽  
S. P. Rao ◽  
M. R. Ricci ◽  
A. Prasad ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Tissue ◽  
Obese Women ◽  
Omental Adipose Tissue ◽  
Before And After ◽  
Severely Obese ◽  
Specific Regulation ◽  
And Function ◽  
Leptin Expression

We investigated the in vitro regulation of leptin expression in adipose tissue from severely obese women and men before and after culture with insulin (7 nM) and/or dexamethasone (25 nM). Leptin mRNA and leptin secretion were two- to threefold higher in subcutaneous vs. omental adipose tissue before culture. Dexamethasone transiently increased leptin mRNA approximately twofold in both depots after 1 day of culture [ P < 0.01 vs. basal (no hormone control)], but leptin secretion was only increased in omental adipose tissue ( P < 0.005 vs. basal). Insulin did not increase leptin mRNA in either depot but increased leptin secretion ∼1.5- to 3-fold in subcutaneous tissue throughout 7 days of culture ( P < 0.05 vs. basal). The combination of insulin and dexamethasone increased leptin mRNA and leptin secretion approximately two- to threefold in both depots at day 1( P < 0.005 vs. basal or insulin) and maintained leptin expression throughout 7 days of culture. We conclude that insulin and glucocorticoid have depot-specific effects and function synergistically as long-term regulators of leptin expression in omental and subcutaneous adipose tissue from obese subjects.

scholarly journals Effect of exercise training intensity on adipose tissue hormone sensitive lipase gene expression in obese women under weight loss

2012 ◽  
Vol 1 (3) ◽  
pp. 184-190 ◽  
Author(s):  
Tongjian You ◽  
Xuewen Wang ◽  
Rongze Yang ◽  
Mary F. Lyles ◽  
Dawei Gong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Exercise Training ◽  
Hormone Sensitive Lipase ◽  
Obese Women ◽  
Training Intensity ◽  
Lipase Gene ◽  
Hormone Sensitive

Abstract 469: Influences of Dietary Weight Reduction on the Atrial Natriuretic Peptide System in Obese Subjects

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Sven Haufe ◽  
Stefan Engeli ◽  
Ralf Lichtinghagen ◽  
Wolfgang Utz ◽  
Jeanette Schulz-Menger ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Weight Reduction ◽  
Plasma Concentrations ◽  
Left Ventricular ◽  
Obese Women ◽  
Obese Subjects ◽  
Atrial Natriuretic

In obese individuals, reduced atrial natriuretic peptide (ANP) bioavailability appears to promote arterial hypertension and type 2 diabetes likely through direct metabolic actions. Mid-regional pro-ANP is cleaved off during ANP processing, thus, serving as ANP release marker. We hypothesized that dietary weight reduction improves ANP release. In 75 overweight and obese women and men who had lost >5% body weight during six months hypocaloric dieting (-9.1±3.8 kg), we analyzed venous mid-regional pro-ANP and natriuretic peptide receptor (NPR) expression in abdominal subcutaneous adipose tissue before and after the intervention. Participants underwent ambulatory blood pressure (ABPM) monitoring and cardiac magnetic resonance imaging. ABPM decreased from 118±9/73±7 to 115±9/71±6 mm Hg and left ventricular mass from 92±20 to 86±19 g (p<0.05 for all). End-diastolic and end-systolic volumes remained unchanged. Mid-regional pro-ANP plasma concentrations did not respond to weight loss (before: 51±24 pmol/; after 53± 24 pmol/l) and increased similarly during exercise testing. Adipose NPR-A mRNA expression remained unchanged whereas NPR-C receptor mRNA decreased from 1.2±0.7 to 1.0±0.5 (p<0.05). Our data suggest that dietary weight loss does not augment ANP release in overweight and obese subjects. However, weight loss could improve ANP bioavailability through decreased clearance. Possible mechanisms are reduced fat mass and reduced expression of adipose tissue ANP scavenger receptor NPR-C.

Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans

2003 ◽  
Vol 285 (3) ◽  
pp. E527-E533 ◽  
Author(s):  
Jens M. Bruun ◽  
Aina S. Lihn ◽  
Camilla Verdich ◽  
Steen B. Pedersen ◽  
Søren Toubro ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Mrna Levels ◽  
Plasma Adiponectin ◽  
Tnf Α ◽  
Adiponectin Mrna ◽  
Before And After

Adiponectin is an adipose tissue-specific protein that is abundantly present in the circulation and suggested to be involved in insulin sensitivity and development of atherosclerosis. Because cytokines are suggested to regulate adiponectin, the aim of the present study was to investigate the interaction between adiponectin and three adipose tissue-derived cytokines (IL-6, IL-8, and TNF-α). The study was divided into three substudies as follows: 1) plasma adiponectin and mRNA levels in adipose tissue biopsies from obese subjects [mean body mass index (BMI): 39.7 kg/m2, n = 6] before and after weight loss; 2) plasma adiponectin in obese men (mean BMI: 38.7 kg/m2, n = 19) compared with lean men (mean BMI: 23.4 kg/m2, n = 10) before and after weight loss; and 3) in vitro direct effects of IL-6, IL-8, and TNF-α on adiponectin mRNA levels in adipose tissue cultures. The results were that 1) weight loss resulted in a 51% ( P < 0.05) increase in plasma adiponectin and a 45% ( P < 0.05) increase in adipose tissue mRNA levels; 2) plasma adiponectin was 53% ( P < 0.01) higher in lean compared with obese men, and plasma adiponectin was inversely correlated with adiposity, insulin sensitivity, and IL-6; and 3) TNF-α ( P < 0.01) and IL-6 plus its soluble receptor ( P < 0.05) decreased adiponectin mRNA levels in vitro. The inverse relationship between plasma adiponectin and cytokines in vivo and the cytokine-induced reduction in adiponectin mRNA in vitro suggests that endogenous cytokines may inhibit adiponectin. This could be of importance for the association between cytokines (e.g., IL-6) and insulin resistance and atherosclerosis.

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