scholarly journals Stabilizing and improving elastic bioengineered scaffolds mimicking extracellular matrix for use in wound repair and regeneration

SPE Polymers ◽  
2021 ◽  
Author(s):  
Harleigh Warner ◽  
William D. Wagner
Keyword(s):  
Extracellular Matrix ◽  
Wound Repair

scholarly journals Special Issue: Application of Extracellular Matrix in Regenerative Medicine

2021 ◽  
Vol 11 (7) ◽  
pp. 3262
Author(s):  
Neill J. Turner
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Wound Repair ◽  
Three Dimensional ◽  
Dynamic Structure ◽  
Scaffold Material ◽  
Special Issue ◽  
Organ Regeneration ◽  
Scaffold Materials ◽  
The Many

The present Special Issue comprises a collection of articles addressing the many ways in which extracellular matrix (ECM), or its components parts, can be used in regenerative medicine applications. ECM is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells. Consequently, ECM can be considered as nature’s ideal biologic scaffold material. The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.

scholarly journals The Role of the Extracellular Matrix Components in Cutaneous Wound Healing

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Pawel Olczyk ◽  
Łukasz Mencner ◽  
Katarzyna Komosinska-Vassev
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factors ◽  
Wound Repair ◽  
Structural Integrity ◽  
Healing Process ◽  
Cellular Functions ◽  
Extracellular Matrix Components ◽  
Essential Components ◽  
Matrix Components

Wound healing is the physiologic response to tissue trauma proceeding as a complex pathway of biochemical reactions and cellular events, secreted growth factors, and cytokines. Extracellular matrix constituents are essential components of the wound repair phenomenon. Firstly, they create a provisional matrix, providing a structural integrity of matrix during each stage of healing process. Secondly, matrix molecules regulate cellular functions, mediate the cell-cell and cell-matrix interactions, and serve as a reservoir and modulator of cytokines and growth factors’ action. Currently known mechanisms, by which extracellular matrix components modulate each stage of the process of soft tissue remodeling after injury, have been discussed.

scholarly journals Proteolytic Events of Wound-Healing — Coordinated Interactions Among Matrix Metalloproteinases (MMPs), Integrins, and Extracellular Matrix Molecules

2001 ◽  
Vol 12 (5) ◽  
pp. 373-398 ◽  
Author(s):  
Bjorn Steffensen ◽  
Lari Häkkinen ◽  
Hannu Larjava
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Matrix Metalloproteinases ◽  
Wound Repair ◽  
Enzyme Activation ◽  
Processing Enzymes ◽  
The Matrix ◽  
Signaling Receptors ◽  
State Of Rest ◽  
And Function

During wound-healing, cells are required to migrate rapidly into the wound site via a proteolytically generated pathway in the provisional matrix, to produce new extracellular matrix, and, subsequently, to remodel the newly formed tissue matrix during the maturation phase. Two classes of molecules cooperate closely to achieve this goal, namely, the matrix adhesion and signaling receptors, the integrins, and matrix-degrading and -processing enzymes, the matrix metalloproteinases (MMPs). There is now substantial experimental evidence that blocking key molecules of either group will prevent or seriously delay wound-healing. It has been known for some time now that cell adhesion by means of the integrins regulates the expression of MMPs. In addition, certain MMPs can bind to integrins or other receptors on the cell surface involved in enzyme activation, thereby providing a mechanism for localized matrix degradation. By proteolytically modifying the existing matrix molecules, the MMPs can then induce changes in cell behavior and function from a state of rest to migration. During wound repair, the expression of integrins and MMPs is simultaneously up-regulated. This review will focus on those aspects of the extensive knowledge of fibroblast and keratinocyte MMPs and integrins in biological processes that relate to wound-healing.

scholarly journals Periostin localizes to cells in normal skin, but is associated with the extracellular matrix during wound repair

2009 ◽  
Vol 3 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Linda Jackson-Boeters ◽  
Weiyan Wen ◽  
Douglas W. Hamilton
Keyword(s):  
Extracellular Matrix ◽  
Wound Repair ◽  
Normal Skin

scholarly journals Extracellular matrix plasticity as a driver of cell spreading

2020 ◽  
Vol 117 (42) ◽  
pp. 25999-26007
Author(s):  
Joshua M. Grolman ◽  
Philipp Weinand ◽  
David J. Mooney
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Wound Repair ◽  
Kinetic Monte Carlo ◽  
Cell Spreading ◽  
Cell Biophysics ◽  
Biological Processes ◽  
Kinetic Monte Carlo Simulations ◽  
Network Plasticity ◽  
And Migration

Mammalian cell morphology has been linked to the viscoelastic properties of the adhesion substrate, which is particularly relevant in biological processes such as wound repair and embryonic development where cell spreading and migration are critical. Plastic deformation, degradation, and relaxation of stress are typically coupled in biomaterial systems used to explore these effects, making it unclear which variable drives cell behavior. Here we present a nondegradable polymer architecture that specifically decouples irreversible creep from stress relaxation and modulus. We demonstrate that network plasticity independently controls mesenchymal stem cell spreading through a biphasic relationship dependent on cell-intrinsic forces, and this relationship can be shifted by inhibiting actomyosin contractility. Kinetic Monte Carlo simulations also show strong correlation with experimental cell spreading data as a function of the extracellular matrix (ECM) plasticity. Furthermore, plasticity regulates many ECM adhesion and remodeling genes. Altogether, these findings confirm a key role for matrix plasticity in stem cell biophysics, and we anticipate this will have ramifications in the design of biomaterials to enhance therapeutic applications of stem cells.

scholarly journals 894 Regulatory and effector T-cells potentiate wound repair by regulating inflammation and extracellular matrix

2017 ◽  
Vol 137 (5) ◽  
pp. S154
Author(s):  
X. Wang ◽  
S. Balaji ◽  
M. Rae ◽  
K. Matatall ◽  
H. Li ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
T Cells ◽  
Wound Repair ◽  
Effector T Cells

Functional Bilayered Skin Substitute Constructed by Tissue-Engineered Extracellular Matrix and Microsphere-Incorporated Gelatin Hydrogel for Wound Repair

2009 ◽  
Vol 15 (9) ◽  
pp. 2617-2624 ◽  
Author(s):  
Sha Huang ◽  
Yongjie Zhang ◽  
Liang Tang ◽  
Zhihong Deng ◽  
Wei Lu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Repair ◽  
Skin Substitute ◽  
Gelatin Hydrogel

Synergistic Angiogenesis Promoting Effects of Extracellular Matrix Scaffolds and Adipose-Derived Stem Cells During Wound Repair

2011 ◽  
Vol 17 (5-6) ◽  
pp. 725-739 ◽  
Author(s):  
Shiyu Liu ◽  
Hongmei Zhang ◽  
Xiaojun Zhang ◽  
Wei Lu ◽  
Xinhui Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Wound Repair ◽  
Adipose Derived Stem Cells ◽  
Extracellular Matrix Scaffolds
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