Human Mononuclear Cell Survival and Proliferation is Modulated by Cold Atmospheric Plasma Jet

2013 ◽  
Vol 10 (8) ◽  
pp. 706-713 ◽  
Author(s):  
Sander Bekeschus ◽  
Kai Masur ◽  
Julia Kolata ◽  
Kristian Wende ◽  
Anke Schmidt ◽  
...  
Keyword(s):  
Cell Survival ◽  
Mononuclear Cell ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Human Mononuclear Cell ◽  
Cell Survival And Proliferation

scholarly journals Tiny Cold Atmospheric Plasma Jet for Biomedical Applications

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 249
Author(s):  
Zhitong Chen ◽  
Richard Obenchain ◽  
Richard E. Wirz
Keyword(s):  
Biomedical Applications ◽  
Plasma Jet ◽  
Discharge Voltage ◽  
Plasma Jets ◽  
Atmospheric Plasma ◽  
Physical Parameters ◽  
Cold Atmospheric Plasma ◽  
Water Metal ◽  
Plasma Probe ◽  
Jet Nozzle

Conventional plasma jets for biomedical applications tend to have several drawbacks, such as high voltages, high gas delivery, large plasma probe volume, and the formation of discharge within the organ. Therefore, it is challenging to employ these jets inside a living organism’s body. Thus, we developed a single-electrode tiny plasma jet and evaluated its use for clinical biomedical applications. We investigated the effect of voltage input and flow rate on the jet length and studied the physical parameters of the plasma jet, including discharge voltage, average gas and subject temperature, and optical emissions via spectroscopy (OES). The interactions between the tiny plasma jet and five subjects (de-ionized (DI) water, metal, cardboard, pork belly, and pork muscle) were studied at distances of 10 mm and 15 mm from the jet nozzle. The results showed that the tiny plasma jet caused no damage or burning of tissues, and the ROS/RNS (reactive oxygen/nitrogen species) intensity increased when the distance was lowered from 15 mm to 10 mm. These initial observations establish the tiny plasma jet device as a potentially useful tool in clinical biomedical applications.

Promotion of Wound Healing of Genetic Diabetic Mice Treated by a Cold Atmospheric Plasma Jet

2019 ◽  
Vol 47 (11) ◽  
pp. 4848-4860 ◽  
Author(s):  
Donghai Li ◽  
Guiling Li ◽  
Jing Li ◽  
Zhi-Qiang Liu ◽  
Xuman Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Diabetic Mice ◽  
Cold Atmospheric Plasma

Inhibition of bacterial growth on zirconia abutment with a helium cold atmospheric plasma jet treatment

2020 ◽  
Vol 24 (4) ◽  
pp. 1465-1477 ◽  
Author(s):  
Yang Yang ◽  
Miao Zheng ◽  
Yang Yang ◽  
Jing Li ◽  
Yong-Fei Su ◽  
...  
Keyword(s):  
Bacterial Growth ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Parameters Affecting the Antimicrobial Properties of Cold Atmospheric Plasma Jet

2019 ◽  
Vol 8 (11) ◽  
pp. 1930 ◽  
Author(s):  
Bih-Show Lou ◽  
Chih-Ho Lai ◽  
Teng-Ping Chu ◽  
Jang-Hsing Hsieh ◽  
Chun-Ming Chen ◽  
...  
Keyword(s):  
Gas Flow ◽  
Treatment Time ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Gas Flow Rate ◽  
Cold Atmospheric Plasma ◽  
E Coli ◽  
Antimicrobial Efficiency ◽  
Ar Gas ◽  
Sample Distance

Using the Taguchi method to narrow experimental parameters, the antimicrobial efficiency of a cold atmospheric plasma jet (CAPJ) treatment was investigated. An L9 array with four parameters of CAPJ treatments, including the application voltage, CAPJ-sample distance, argon (Ar) gas flow rate, and CAPJ treatment time, were applied to examine the antimicrobial activity against Escherichia coli (E. coli). CAPJ treatment time was found to be the most influential parameter in its antimicrobial ability by evaluation of signal to noise ratios and analysis of variance. 100% bactericidal activity was achieved under the optimal bactericidal activity parameters including the application voltage of 8.5 kV, CAPJ-sample distance of 10 mm, Ar gas flow rate of 500 sccm, and CAPJ treatment time of 300 s, which confirms the efficacy of the Taguchi method in this design. In terms of the mechanism of CAPJ’s antimicrobial ability, the intensity of hydroxyl radical produced by CAPJ positively correlated to its antimicrobial efficiency. The CAPJ antimicrobial efficiency was further evaluated by both DNA double-strand breaks analysis and scanning electron microscopy examination of CAPJ treated bacteria. CAPJ destroyed the cell wall of E. coli and further damaged its DNA structure, thus leading to successful killing of bacteria. This study suggests that optimal conditions of CPAJ can provide effective antimicrobial activity and may be grounds for a novel approach for eradicating bacterial infections.

scholarly journals Selective treatments of prostate tumor cells with a cold atmospheric plasma jet

2020 ◽  
Vol 17-18 ◽  
pp. 100098 ◽  
Author(s):  
Mohamed Fofana ◽  
Julio Buñay ◽  
Florian Judée ◽  
Silvère Baron ◽  
Sébastien Menecier ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Plasma Jet ◽  
Prostate Tumor ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Prostate Tumor Cells

scholarly journals Reduction and degradation of amyloid aggregates by a pulsed radio-frequency cold atmospheric plasma jet

2009 ◽  
Vol 11 (11) ◽  
pp. 115024 ◽  
Author(s):  
D L Bayliss ◽  
J L Walsh ◽  
G Shama ◽  
F Iza ◽  
M G Kong
Keyword(s):  
Radio Frequency ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Amyloid Aggregates
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