scholarly journals Cover Picture: Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications (View 5/2021)

View ◽  
2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Xiao Jin ◽  
Weitao Yang ◽  
Yan Xu ◽  
Kexin Bian ◽  
Bingbo Zhang
Keyword(s):  
Mr Imaging ◽  
Biomedical Applications ◽  
Imaging Probes

scholarly journals Synthesis, Characterization and Evaluation of Peptide Nanostructures for Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4587
Author(s):  
Fanny d’Orlyé ◽  
Laura Trapiella-Alfonso ◽  
Camille Lescot ◽  
Marie Pinvidic ◽  
Bich-Thuy Doan ◽  
...  
Keyword(s):  
Amino Acids ◽  
Biomedical Applications ◽  
Chemical Reactivity ◽  
Physical Stability ◽  
Chemical Properties ◽  
Building Blocks ◽  
Imaging Probes ◽  
Therapeutic Molecules

There is a challenging need for the development of new alternative nanostructures that can allow the coupling and/or encapsulation of therapeutic/diagnostic molecules while reducing their toxicity and improving their circulation and in-vivo targeting. Among the new materials using natural building blocks, peptides have attracted significant interest because of their simple structure, relative chemical and physical stability, diversity of sequences and forms, their easy functionalization with (bio)molecules and the possibility of synthesizing them in large quantities. A number of them have the ability to self-assemble into nanotubes, -spheres, -vesicles or -rods under mild conditions, which opens up new applications in biology and nanomedicine due to their intrinsic biocompatibility and biodegradability as well as their surface chemical reactivity via amino- and carboxyl groups. In order to obtain nanostructures suitable for biomedical applications, the structure, size, shape and surface chemistry of these nanoplatforms must be optimized. These properties depend directly on the nature and sequence of the amino acids that constitute them. It is therefore essential to control the order in which the amino acids are introduced during the synthesis of short peptide chains and to evaluate their in-vitro and in-vivo physico-chemical properties before testing them for biomedical applications. This review therefore focuses on the synthesis, functionalization and characterization of peptide sequences that can self-assemble to form nanostructures. The synthesis in batch or with new continuous flow and microflow techniques will be described and compared in terms of amino acids sequence, purification processes, functionalization or encapsulation of targeting ligands, imaging probes as well as therapeutic molecules. Their chemical and biological characterization will be presented to evaluate their purity, toxicity, biocompatibility and biodistribution, and some therapeutic properties in vitro and in vivo. Finally, their main applications in the biomedical field will be presented so as to highlight their importance and advantages over classical nanostructures.

Responsive MR-imaging probes for N-methyl-d-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy

2013 ◽  
Vol 4 (8) ◽  
pp. 3148 ◽  
Author(s):  
Neil Sim ◽  
Sven Gottschalk ◽  
Robert Pal ◽  
Jörn Engelmann ◽  
David Parker ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Cell Surface ◽  
Optical Microscopy ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Imaging Probes

Gd2O3 and GH combined with red blood cells to improve the sensitivity of contrast agents for cancer targeting MR imaging

2017 ◽  
Vol 5 (1) ◽  
pp. 46-49 ◽  
Author(s):  
Kunchi Zhang ◽  
Yi Cao ◽  
Ye Kuang ◽  
Min Liu ◽  
Yang Chen ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Gadolinium Oxide ◽  
Hybrid Nanoparticles ◽  
Oxide Nanoparticles ◽  
Cancer Targeting ◽  
Imaging Probes ◽  
Gadolinium Oxide Nanoparticles

Efficient MR imaging probes were fabricated by incorporating gadolinium oxide nanoparticles (Gd2O3) and gadolinium hybrid nanoparticles (GH) within RBCs.

scholarly journals A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes

2018 ◽  
Vol 29 (11) ◽  
pp. 3544-3549 ◽  
Author(s):  
Matthew W. Rotz ◽  
Robert J. Holbrook ◽  
Keith W. MacRenaris ◽  
Thomas J. Meade
Keyword(s):  
Mr Imaging ◽  
Synthetic Approach ◽  
Imaging Probes

scholarly journals Radiolabeled Molecular Imaging Probes for the In Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications

2018 ◽  
Vol 20 (2) ◽  
pp. 674-683 ◽  
Author(s):  
Surachet Imlimthan ◽  
Sofia Otaru ◽  
Outi Keinänen ◽  
Alexandra Correia ◽  
Kalle Lintinen ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Cellulose Nanocrystals ◽  
Biomedical Applications ◽  
In Vivo Evaluation ◽  
Molecular Imaging Probes ◽  
Imaging Probes

Comparative in vitro studies of MR imaging probes for metabotropic glutamate subtype-5 receptor targeting

2013 ◽  
Vol 11 (36) ◽  
pp. 6131 ◽  
Author(s):  
Sven Gottschalk ◽  
Jörn Engelmann ◽  
Gabriele A. Rolla ◽  
Mauro Botta ◽  
David Parker ◽  
...  
Keyword(s):  
Mr Imaging ◽  
In Vitro Studies ◽  
Receptor Targeting ◽  
Metabotropic Glutamate ◽  
Imaging Probes

Bioimaging Applications of Non-Lamellar Liquid Crystalline Nanoparticles

2021 ◽  
Vol 21 (5) ◽  
pp. 2742-2759
Author(s):  
Sergio Murgia ◽  
Stefania Biffi ◽  
Marco Fornasier ◽  
Vito Lippolis ◽  
Giacomo Picci ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Liquid Crystalline ◽  
Colloidal Nanoparticles ◽  
Self Assembling ◽  
Complex Architectures ◽  
Imaging Probes ◽  
Bicontinuous Cubic ◽  
Liquid Crystalline Nanoparticles

Self-assembling processes of amphiphilic lipids in water give rise to complex architectures known as lyotropic liquid crystalline (LLC) phases. Particularly, bicontinuous cubic and hexagonal LLC phases can be dispersed in water forming colloidal nanoparticles respectively known as cubosomes and hexosomes. These non-lamellar LLC dispersions are of particular interest for pharmaceutical and biomedical applications as they are potentially non-toxic, chemically stable, and biocompatible, also allowing encapsulation of large amounts of drugs. Furthermore, conjugation of specific moieties enables their targeting, increasing therapeutic efficacies and reducing side effects by avoiding exposure of healthy tissues. In addition, as they can be easy loaded or functionalized with both hydrophobic and hydrophilic imaging probes, cubosomes and hexosomes can be used for the engineering of multifunctional/theranostic nanoplatforms. This review outlines recent advances in the applications of cubosomes and hexosomes for in vitro and in vivo bioimaging.

scholarly journals MR imaging probes: design and applications

2015 ◽  
Vol 44 (11) ◽  
pp. 4804-4818 ◽  
Author(s):  
Eszter Boros ◽  
Eric M. Gale ◽  
Peter Caravan
Keyword(s):  
Mr Imaging ◽  
Imaging Probes

This perspective outlines strategies towards the development of MR imaging probes that our lab has explored.

Sign in / Sign up

Export Citation Format

Share Document