Evidence of a Functional Role for the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1/MDA6in the Reciprocal Regulation of PKC Activator-Induced Apoptosis and Differentation in Human Myelomonocytic Leukemia Cells

1998 ◽  
Vol 244 (1) ◽  
pp. 105-116 ◽  
Author(s):  
Zhiliang Wang ◽  
Zao-zhong Su ◽  
Paul B. Fisher ◽  
Shujie Wang ◽  
Glenn VanTuyle ◽  
...  
Keyword(s):  
Functional Role ◽  
Kinase Inhibitor ◽  
Leukemia Cells ◽  
Cyclin Dependent Kinase ◽  
Reciprocal Regulation ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Induced Apoptosis ◽  
Myelomonocytic Leukemia

Myc Targets Cks1 To Provoke Proliferation and Lymphomagenesis.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2618-2618
Author(s):  
Ulrich Keller ◽  
Jennifer B. Old ◽  
Jonas Nilsson ◽  
Lisa Nilsson ◽  
Kirsteen Maclean ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
B Cells ◽  
Burkitt Lymphoma ◽  
Poor Prognosis ◽  
Transcriptional Activity ◽  
Kinase Inhibitor ◽  
Ex Vivo ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Induced Apoptosis

Abstract Reduced levels of the cyclin dependent kinase inhibitor p27Kip1 connote poor prognosis in cancer. In human Burkitt lymphoma, and in pre-cancerous B cells and lymphomas arising in Eμ-Myc transgenic mice, p27Kip1 expression is markedly reduced. Furthermore, the Cks1 component of the SCFSkp2 complex that is necessary for p27Kip1 ubiquitylation and degradation, and to a lesser extent Skp2, are induced by Myc ex vivo and in Eμ-Myc B-cells and lymphomas, and up-regulation of CKS1 and SKP2 are hallmarks of Burkitt lymphoma. While loss of Skp2 has rather modest effects, the deletion of Cks1 in Eμ-Myc B-cells elevates p27Kip1 levels, reduces proliferation and delays lymphoma development. In contrast, Myc-induced apoptosis and transcriptional activity are not affected by Cks1 (or Skp2) loss. Therefore, Myc accelerates cell proliferation and promotes tumorigenesis through its ability to selectively induce Cks1.

scholarly journals Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells

Leukemia ◽  
2004 ◽  
Vol 18 (4) ◽  
pp. 747-755 ◽  
Author(s):  
I N Hahntow ◽  
F Schneller ◽  
M Oelsner ◽  
K Weick ◽  
I Ringshausen ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor

Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis

2003 ◽  
Vol 45 (5) ◽  
pp. 672-683 ◽  
Author(s):  
Elvira G Jorda ◽  
Ester Verdaguer ◽  
Anna M Canudas ◽  
Andrés Jiménez ◽  
Alejandra Bruna ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Induced Apoptosis ◽  
Neuroprotective Action
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