In Hiroshima Prefecture, an inter-university collaborative educational project of an interdisciplinary field: Clinical Informatics and Technology (the CIT program) has being implemented. As a part of the CIT program, we have been working on CISTEM (Clinical Information, Science, Technology, Engineering, Mathematics, and Medicine) education to establish a systematic educational curriculum for students (mainly undergraduate students) who will be responsible for medical engineering cooperation/collaboration in the future. In this paper, from the viewpoints of communication and control engineering, we introduce an attempt to enhance students’ problem consciousness and motivation for research and development by facilitating their self-discovery of the design principles commonly required for medical instruments and medical systems through production tasks utilizing robotic platforms. Especially we introduce our case studies focusing on the significance of human-human synchrony and human-machine synchrony towards the realization of symbiosis among humans and machines. We further propose a model case of an CISTEM education customized for undergraduate students who specialize in information, communication and control engineering based on trials conducted in these case studies.