A Matter of Fat: Body Fat Distribution and Cardiometabolic in

2021 ◽  
pp. 37-56
Author(s):  
Nasrin Goolam Mahyoodeen ◽  
Nigel J. Crowther
Keyword(s):  
Body Fat ◽  
Fat Body ◽  
Fat Distribution ◽  
Body Fat Distribution

scholarly journals Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children

2017 ◽  
Vol 30 (4) ◽  
Author(s):  
Magnus Dencker ◽  
Anton Danielson ◽  
Magnus K. Karlsson ◽  
Per Wollmer ◽  
Lars B. Andersen ◽  
...  
Keyword(s):  
Body Fat ◽  
Fatty Acid Binding Protein ◽  
Fat Body ◽  
Community Sample ◽  
Fat Distribution ◽  
Abdominal Fat ◽  
Body Fat Distribution ◽  
Fatty Acid Binding ◽  
Total Body Fat ◽  
Total Body

AbstractBackground:The aim of the study was to assess possible relationships between adipocyte fatty acid-binding protein (FABP4) and total body fat (TBF), abdominal fat, body fat distribution, aerobic fitness, blood pressure, cardiac dimensions and the increase in body fat over 2 years in a community sample of children.Methods:A cross-sectional study was used in a community sample of 170 (92 boys and 78 girls) children aged 8–11 years. TBF and abdominal fat (AFM) were measured by dual-energy X-ray absorptiometry (DXA). TBF was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VOResults:Partial correlations, with adjustment for sex, between FABP4 vs. ln TBF, ln BF%, ln AFM, AFM/TBF and VOConclusions:Findings from this community-based cohort of young children show that increased body fat and abdominal fat, more abdominal body fat distribution, low fitness, more LVM and increased LA, increased SBP and PP were all associated with increased levels of FABP4. Increase in TBF and abdominal fat over 2 years were also associated with increased levels of FABP4.

scholarly journals Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size

2018 ◽  
Vol 177 (3) ◽  
pp. 461-467 ◽  
Author(s):  
Magnus Dencker ◽  
Daniel Arvidsson ◽  
Magnus K. Karlsson ◽  
Per Wollmer ◽  
Lars B. Andersen ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Body ◽  
Fat Distribution ◽  
Abdominal Fat ◽  
Body Fat Distribution ◽  
Total Body Fat ◽  
Galectin 3 ◽  
Total Body

scholarly journals Body fat, body fat distribution, lean body mass and atrial fibrillation and flutter. A Danish cohort study

Obesity ◽  
2014 ◽  
Vol 22 (6) ◽  
pp. 1546-1552 ◽  
Author(s):  
Lars Frost ◽  
Emelia J. Benjamin ◽  
Morten Fenger-Grøn ◽  
Asger Pedersen ◽  
Anne Tjønneland ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Lean Body Mass ◽  
Body Mass ◽  
Body Fat ◽  
Fat Body ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Danish Cohort ◽  
Atrial Fibrillation And Flutter

scholarly journals Body Fat Distribution in Trunk and Legs Are Associated With Cardiometabolic Risk Clustering Among Chinese Adolescents Aged 10-18 Years Old

2020 ◽  
Author(s):  
Qingmei Yang ◽  
Ping Ma ◽  
Hao Zhang ◽  
Rongrong Cai ◽  
Yangyang Dong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Fat ◽  
Fat Mass ◽  
Cardiometabolic Risk ◽  
Fat Body ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Chinese Adolescents ◽  
Cardiometabolic Risk Factors ◽  
Body Fat Mass

Abstract Background: The association between total fat, body fat distribution and cardiometabolic risk factors are highly controversial among adolescents. The aim of the present study was to evaluate the association of body fat distribution with cardiometabolic risk factors clustering among Chinese adolescents.Methods: In this cross-sectional study a total of 1175 adolescents aged 10 to 18 years underwent a comprehensive assessment of cardimetabolic risk factors. Body fat analysis was performed with Bioelectrical impedance analysis. Results: Individuals with the CVRFs ≥1 or CVRFs ≥2 had higher indices of body fat distribution such as body fat mass(BFM) compared to those with normal CVRFs (all P<0.001). The prevalence of CVRFs ≥1, CVRFs ≥2 increased with increasing of the quartile of BFM, TBFM, ABFM, LBFM, PBF, VFL compared to normal subjects. After adjusted for age and sex, the study indicated an linear relationship between TBFM(β=0.693, 95%CI:0.363,1.023), LBFM(β=-1.471, 95%CI:-2.768,-0.175) and CVRFs z-score. Logistic regression models suggested TBFM was associated with CVRFs≥1 and CVRFs≥2 by higher odds. Lower odds of LBFM was associated with CVRFs≥2. Conclusions A significant association between body fat mass of trunk(TBFM), body fat mass of leg(LBFM) and cluster of cardiometabolic risk factors was showed in the study. It suggested to reduce body fat mass of trunk and increase body fat mass of leg were essential for adolescents to prevent cardiovascular risk factors clustering.

Abstract 50: Adiposity is Associated with Genome-wide DNA Methylation in Adipose Tissue

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Golareh Agha ◽  
Andres E Houseman ◽  
Karl T Kelsey ◽  
Charles B Eaton ◽  
Stephen L Buka ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Adipose Tissue ◽  
Body Fat ◽  
Fat Body ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Nucleotide Polymorphisms ◽  
Genome Wide ◽  
Differentially Methylated Genes ◽  
Central Fat

Background: Adiposity is a major risk factor for type 2 diabetes, dyslipidemia, and CVD, suggesting an important role for adipose tissue in development of these conditions. There is interest in epigenetic mechanisms by which genetic and environmental factors may contribute to adiposity, however studies of DNA methylation in relation to adiposity rarely focus on adipose tissue. Objective: To determine whether genome-wide DNA methylation profiles in blood and adipose tissue are associated with central fat, body fat distribution, and obesity in adulthood. Methods: Participants (aged 44-50 years) were from the New England Family Study birth cohort, born in Providence, RI . Of 400 participants assessed during 2010-2011, a representative subsample of 106 participants (68 women, 38 men) was selected for DNA methylation analyses. DNA methylation in subcutaneous adipose tissue and peripheral blood leukocytes was evaluated using the Infinium HumanMethylation450K BeadChip. Dual-energy x-ray absorptiometry scans assessed android fat mass, android:gynoid region fat ratio, and trunk:limb region fat ratio. BMI (kg/m 2 ) was directly assessed. Results: Adipose tissue DNA methylation was associated with all four measures of adiposity, after adjusting for race, sex, smoking, and accounting for multiple testing (permutation-based omnibus p-values <0.001). Associations were similar in sex-specific analyses, and upon exclusion of single nucleotide polymorphisms. Investigation of top differentially-methylated genes revealed several that are biologically relevant to adiposity development, including SOD3 , AOC3 , AQP7, TIMP4, ANGPT4, and ADAMTS4 . Blood DNA methylation was not related to adiposity. Conclusion: Adipose tissue DNA methylation was associated with directly-assessed measures of central fat and body fat distribution, as well as obesity, all of which are important determinants of cardiometabolic risk. Targeting the primary affected organ may be important for elucidating the epigenetic basis of adiposity.

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure

2009 ◽  
Vol 34 (1) ◽  
pp. 182-189 ◽  
Author(s):  
S I I Kring ◽  
C Holst ◽  
S Toubro ◽  
A Astrup ◽  
T Hansen ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Body Fat ◽  
Fat Body ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Common Variants ◽  
Metabolic Traits

Body Fat Distribution and Body Composition During GnRH Agonist Therapy

2001 ◽  
Vol 97 (3) ◽  
pp. 338-342 ◽  
Author(s):  
HIDEKI YAMASAKI ◽  
TSUTOMU DOUCHI ◽  
SHINAKO YAMAMOTO ◽  
TOSHIMICHI OKI ◽  
RIKI KUWAHATA ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Gnrh Agonist ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Agonist Therapy
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