VARIATIONAL TECHNIQUE FOR ENVIRONMENTAL RISK/VULNERABILTY ASSESSMENT AND CONTROL

2007 ◽  
pp. 15-28
Author(s):  
VLADIMIR PENENKO ◽  
ELENA TSVETOVA
Keyword(s):  
Environmental Risk ◽  
Variational Technique ◽  
And Control

scholarly journals Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanan Zhang ◽  
Huan Liu ◽  
Xialu Lin ◽  
Feng’e Zhang ◽  
Peilin Meng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cell Cycle ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Environmental Risk ◽  
Pluripotent Stem Cells ◽  
Environmental Risk Factors ◽  
P53 Pathway ◽  
Induced Pluripotent ◽  
And Control

Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD. We used successfully generated KBD human induced pluripotent stem cells (hiPSCs) and control hiPSCs, which carry different genetic information. They have potential significance in exploring the effects of HT-2 toxin on hiPSC chondrocytes and interactive genes with HT-2 toxin for the purpose of providing a cellular disease model for KBD. In this study, we gave HT-2 toxin treatment to differentiating hiPSC chondrocytes in order to investigate the different responses of KBD hiPSC chondrocytes and control hiPSC chondrocytes to HT-2 toxin. The morphology of HT-2 toxin-treated hiPSC chondrocytes investigated by transmission electron microscope clearly showed that the ultrastructure of organelles was damaged and type II collagen expression in hiPSC chondrocytes was downregulated by HT-2 treatment. Moreover, dysregulation of cell cycle was observed; and p53, p21, and CKD6 gene expressions were dysregulated in hiPSC chondrocytes after T-2 toxin treatment. Flow cytometry also demonstrated that there were significantly increased amounts of late apoptotic cells in KBD hiPSC chondrocytes and that the mRNA expression level of Fas was upregulated. In addition, KBD hiPSC chondrocytes presented stronger responses to HT-2 toxin than control hiPSC chondrocytes. These findings confirmed that HT-2 is an environmental risk factor of KBD and that p53 pathway interacted with HT-2 toxin, causing damaged ultrastructure of organelles, accelerating cell cycle in G1 phase, and increasing late apoptosis in KBD hiPSC chondrocytes.

Environmental impact assessment and control of pharmaceuticals: the role of environmental agencies

2008 ◽  
Vol 57 (1) ◽  
pp. 91-97 ◽  
Author(s):  
N.E. Adler ◽  
J. Koschorreck ◽  
B. Rechenberg
Keyword(s):  
Environmental Impact ◽  
Environmental Risk ◽  
Ethinyl Estradiol ◽  
Risk Mitigation ◽  
Mitigation Measures ◽  
Management Options ◽  
Federal Environment Agency ◽  
Environment Agency ◽  
And Control ◽  
Environmental Agencies

In 2005, the new legislation for pharmaceuticals came into effect. Since then environmental risk assessments are required for all new marketing authorisation applications. The German Federal Environment Agency has been assessing the environmental impact of 136 veterinary and 134 human pharmaceuticals. The authorisation of pharmaceuticals has shown that the authorisation of some groups of substances have to be combined with risk mitigation measures. Environmental risks may also arise from those pharmaceuticals which were authorised before the environmental risk assessment was added to the requirements of authorisation. Four examples of “existing” pharmaceuticals, i.e. diclofenac, ethinyl estradiol, ivermectin, and florfenicol are highlighted in this article. Risk management options for veterinary and human pharmaceuticals are discussed.

scholarly journals Considerations on Research of Environmental Risk Prevention and Control in “12th Five-Year Plan” Period

2013 ◽  
Vol 02 (02) ◽  
pp. 69-72 ◽  
Author(s):  
Pengli Xue ◽  
Xiaofeng Sun ◽  
Yun Song ◽  
Yanjun Cheng ◽  
Dezhi Sun
Keyword(s):  
Environmental Risk ◽  
Prevention And Control ◽  
Risk Prevention ◽  
Plan Period ◽  
And Control

scholarly journals Business analysis of implementation of UCG technology in Indonesia

2021 ◽  
Vol 882 (1) ◽  
pp. 012082
Author(s):  
Gandhi Kurnia Hudaya ◽  
Miftahul Huda
Keyword(s):  
Environmental Risk ◽  
Coal Gasification ◽  
Underground Coal Gasification ◽  
Full Support ◽  
Business Analysis ◽  
Substitute Products ◽  
The Government ◽  
Almost All ◽  
And Control

Abstract There is a deep-seated coal potency with a depth more than 100 meters below surface in Indonesia that has not been exploited yet. Underground Coal Gasification (UCG) is an unconventional technology that can become the solution to exploit the deep-seated coal potential by extracting coal into in-situ gas that can be converted to electricity or chemicals. Based on business analysis, this paper aims to analyze the implementation of UCG technology in Indonesia, whether it is potential or not. Data are collected from literature and analyzed using Porter Five Forces and PESTLE Analysis. The Porter Five Forces analysis shows that the implementation of UCG in Indonesia is still potential as an industry because the only threat will come from substitute products. PESTLE analysis shows that almost all the factors, except for technology, are very supportive of implementing UCG commercial plants in Indonesia. Based on both studies, it can be concluded that the UCG project is very potential to be developed in Indonesia. However, it needs full support and control from the government because it will become a pioneer project with financial and environmental risk still has not quantified ideally.

scholarly journals Socio-Economic and Environmental Risk Factors of Tuberculosis in Wonosobo, Central Java, Indonesia

2020 ◽  
Vol 16 (1) ◽  
pp. 61-70
Author(s):  
Rita Dian Pratiwi ◽  
Dibyo Pramono ◽  
Junaedi Junaedi
Keyword(s):  
Risk Factors ◽  
Population Density ◽  
Environmental Risk ◽  
Basic Education ◽  
Environmental Risk Factors ◽  
Central Java ◽  
Personal Ventilation ◽  
Higher Temperature ◽  
Lower Temperature ◽  
And Control

This study discusses the dominant socio-economic and environmental risk factors for TB disease. The design of this study was a case-control study with 70 case samples and control with a contribution of n = 1. Variables from this study contacted personal, ventilation of the house, humidity, the temperature of the house, density of the house, kitchen, and family earnings. Multivariate data analysis uses multiple logistic regressions. The study notes that from 140 samples, 47% have basic education, and 30% are farmers. People who had a past of contact with TB cases were ten times more likely to contract TB than those who had no contacted (OR = 10.00; p <0.001). Personalities who live in poorly ventilated homes who have a risk of contracting TB are 2.2 times greater than those who live in homes with standard ventilation (OR = 2.20; p <0.018). The moisture increases the risk of TB by four times the low moisture (OR = 4.00; p = 0.001). Living in a house with a higher temperature of TB is 3.8 times higher than a lower temperature (OR = 3.80; p = 0.009). Living in a high population density of the house improves TB five times more than living in a lesser home (OR = 5.00; p <0.001). Kitchen gas enhances the risk of TB 2.5 times greater than gasless (OR = 2.50; p = 0.007). Low family earnings raise the risk of TB three times greater than high family earnings (OR = 3.00; p = 0.002). A past of contact, poorly ventilated homes, high humidity, hothouse temperature, population density, kitchen gas, and low family earnings, are risk factors for TB in Wonosobo, Central Java.

scholarly journals Evaluation of the Perception and Control Measures towards Environmental Risk in Obio Akpor Local Government Area of Rivers State

2019 ◽  
pp. 1-5
Author(s):  
Cookey A. Tammy ◽  
Tombari Bodo ◽  
Perri T. Owunari
Keyword(s):  
Local Government ◽  
Health Risk ◽  
Environmental Risk ◽  
Health Hazard ◽  
Local Government Area ◽  
Control Measures ◽  
Personal Hygiene ◽  
Survey Method ◽  
Rivers State ◽  
And Control

Aims: To evaluate the perception and control measures towards environmental risk in Obio Akpor Local government area (LGA) of Rivers State. Place and Duration of Study: The study was carried out at the Rivers State Waste Management Agency in Obio-Akpor LGA of Rivers State between January 2019 - March 2019. Methodology: The survey method was employed and the simple random techniques was adopted whilst 265 copies of the questionnaire were used to elicit information from the number of employee. Results: The findings revealed that that majority of the respondents under survey had a good knowledge of occupational health risk and are fully aware of the environmental health risk associated with waste dumping, As a Possible control measures it was revealed that the majority had the opinion that the provision of safety and health structure is the best preventive measures so as to eliminate health hazard among solid waste workers. Conclusion: RIWAMA should establish sanitary facilities where workers can wash after work to ensure effective personal hygiene is maintained and also provide them with Personal protective equipment.

Control of Metal Alloy Oxidation with Electric Fields

1973 ◽  
Vol 31 ◽  
pp. 164-165
Author(s):  
R. R. Dils ◽  
P. S. Follansbee
Keyword(s):  
Electric Fields ◽  
Oxidation Process ◽  
Base Alloy ◽  
Oxide Surface ◽  
Platinum Electrodes ◽  
Insulating Layer ◽  
Iron Base Alloy ◽  
Alloy Oxidation ◽  
Aluminum Oxide Layer ◽  
And Control

Electric fields have been applied across oxides growing on a high temperature alloy and control of the oxidation of the material has been demonstrated. At present, three-fold increases in the oxidation rate have been measured in accelerating fields and the oxidation process has been completely stopped in a retarding field.The experiments have been conducted with an iron-base alloy, Pe 25Cr 5A1 0.1Y, although, in principle, any alloy capable of forming an adherent aluminum oxide layer during oxidation can be used. A specimen is polished and oxidized to produce a thin, uniform insulating layer on one surface. Three platinum electrodes are sputtered on the oxide surface and the specimen is reoxidized.

Evidence for a Blood Ganglion Barrier in the Superior Cervical Ganglion of the Rat

1982 ◽  
Vol 40 ◽  
pp. 204-204
Author(s):  
D. M. DePace
Keyword(s):  
Blood Vessels ◽  
Superior Cervical Ganglion ◽  
Peripheral Nerves ◽  
Time Schedule ◽  
Transmission Electron ◽  
Cervical Ganglion ◽  
The Central Nervous System ◽  
Cervical Ganglia ◽  
Capillary Circulation ◽  
And Control

The majority of blood vessels in the superior cervical ganglion possess a continuous endothelium with tight junctions. These same features have been associated with the blood brain barrier of the central nervous system and peripheral nerves. These vessels may perform a barrier function between the capillary circulation and the superior cervical ganglion. The permeability of the blood vessels in the superior cervical ganglion of the rat was tested by intravenous injection of horseradish peroxidase (HRP). Three experimental groups of four animals each were given intravenous HRP (Sigma Type II) in a dosage of.08 to.15 mg/gm body weight in.5 ml of.85% saline. The animals were sacrificed at five, ten or 15 minutes following administration of the tracer. Superior cervical ganglia were quickly removed and fixed by immersion in 2.5% glutaraldehyde in Sorenson's.1M phosphate buffer, pH 7.4. Three control animals received,5ml of saline without HRP. These were sacrificed on the same time schedule. Tissues from experimental and control animals were reacted for peroxidase activity and then processed for routine transmission electron microscopy.

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